DNA methylation analysis with methylKit in R. Import Bismark coverage files, filter by coverage, normalize samples, and perform statistical comparisons.
Research Tanstack Query (React Query) patterns for server state management using Exa code search and Ref documentation
Master advanced prompt engineering techniques to maximize LLM performance, reliability, and controllability in production.
Manual and automated gating for defining cell populations in flow cytometry. Covers rectangular, polygon, and data-driven gates.
devbooks-entropy-monitor：定期采集系统熵度量（结构熵/变更熵/测试熵/依赖熵），生成量化报告，当指标超阈值时建议重构。用户说"熵度量/复杂度趋势/重构预警/代码健康/技术债务度量"等时使用。
Options trading with OpenAlgo - single leg orders, multi-leg strategies (Iron Condor, Straddle, Strangle, Spreads), options chain analysis, and Greeks calculation
Stay current with how OpenCode, OpenAI Codex, and Claude Code implement extensibility features (skills, slash commands, subagents, custom prompts).
Build tools that agents can use effectively, including architectural reduction patterns — from majiayu000/claude-skill-registry
Strict file creation rules. Loaded FIRST by orchestrator and all agents before any action. Prevents pollution with .md, .json, scripts. Only allows code files and .build/ docs.
NVIDIA NeMo framework for building and training conversational AI models. Use for NeMo Retriever models, RAG (Retrieval-Augmented Generation), embedding models, enterprise search,…
Apply P13 Spatial Framing to scale perspective from local details to global patterns and back.
Setup the Ralph autonomous AI coding loop - ships features while you sleep
End-to-end single-cell RNA-seq workflow from 10X Genomics data to annotated cell types. Covers QC, normalization, clustering, marker detection, and cell type annotation — from…
Draft a senior peer-review report on a social-science manuscript.
Generate AGENTS.md and AI configuration files for your project. Use when the user wants to create agent instructions, set up AI configs, or says "create AGENTS.md", "conf — from…
リスク管理エージェント。リスク識別、評価、対応計画、モニタリングを実施。キーワード: リスク, risk, 課題, issue, 問題, リスク登録簿, リスクマトリックス.
Pull snapshots from all configured metric sources, compute deltas against prior snapshots, flag unexplained signals, and draft evidence entries for canvas files.
Run OpenAI Codex CLI as a subagent for second opinions, code reviews, and questions. Use when you want a different AI model's perspective.
Integrate OpenAI Codex CLI into Claude Code for AI collaboration, code generation, and automated development.
セッション間の学習と記憶の永続化を管理。Use when user asks about previous sessions, history, or to continue from before. Do NOT load for: implementation work, reviews, or ad-hoc information.
Build production Apache Airflow DAGs with best practices for operators, sensors, testing, and deployment.
Analyzes a codebase's modularity imbalances using the Balanced Coupling model and produces a review of design issues.
PocketFlow framework for building LLM applications with graph-based abstractions, design patterns, and agentic coding workflows
Agent assistance skill that provides stuck detection, memory management, and session learning capabilities for AI agents — from majiayu000/claude-skill-registry-data
Build apps with the Claude API or Anthropic SDK. TRIGGER when: code imports `anthropic`/`@anthropic-ai/sdk`/`claude_agent_sdk`, or user asks to use Claude API, Anthropic — from…
A/B test CLAUDE.md instruction changes against eval benchmarks. Capture baselines, test variants, compare results. — from majiayu000/claude-skill-registry
Эксперт DB replication. Используй для настройки репликации MySQL, PostgreSQL, MongoDB, failover и high availability. — from majiayu000/claude-skill-registry-data
Work with FASTQ quality scores using Biopython. Use when analyzing read quality, filtering by quality, trimming low-quality bases, or generating quality reports.
Apply effective software quality consultancy practices. Use when consulting, advising clients, or establishing consultancy workflows. — from majiayu000/claude-skill-registry
Find authoritative answers from official docs, RFCs, standards, and academic sources — never from blogs or opinions
How to do simple but secure deployments using virtual machines on different cloud providers
Render JSON specs to human-readable markdown with AI-enhanced insights, visualizations, and progressive disclosure
OmniHuman1によるAIアバター・リップシンク動画生成ガイド。 Use when: (1) user says「AIアバター」「リップシンク」「OmniHuman」, (2) user wants talking head videos from images, (3) user mentions「アバター動画」「1枚の画像から動画」.
Generate TypeScript client code for interacting with Aztec contracts. Use when building frontend integrations, creating contract clients, or setting up wallet connections.
Identify and resolve ambiguities in specifications through structured questioning. Use when specification has [NEEDS CLARIFICATION] markers, when user mentions unclear or…
Multi-turn conversational AI for intent extraction, clarification, and generation readiness detection.
Analyze complex systems, feedback loops, and leverage points. Avoid linear thinking for complex problems.
Local text-to-speech generation using Chatterbox TTS on Apple Silicon. Use this when users request converting text to audio, reading articles/documents aloud, generating speech…
Transform thousands of wedding photos and hours of footage into an immersive 3D Gaussian Splatting experience with theatre mode replay, face-clustered guest roster, and A — from…
Logging system design guide covering centralized architecture, field standards, and distributed tracing.
Guide to selecting and optimizing embedding models for vector search applications. — from majiayu000/claude-skill-registry
Ressort-Router der Legistik-Werkstatt: leitet nach Auftragsaufnahme in das richtige Bundes-Ressort. Klaert Ressort-Kuerzel BMF; BMI; AA; BMVg; BMWE; BMFTR; BMJV; BMBFSFJ; — from…
Refactor code toward clearer ports and adapters so domain or application logic is less entangled with infrastructure details.
Crypto Twitter intelligence and alpha research. Search X/Twitter for real-time crypto narratives, trending tokens, yield strategies, smart money signals, and protocol research.
Use when challenging assumptions, surfacing risks, or stress-testing designs and decisions. Triggers: 'challenge this', 'play devil's advocate', 'what could go wrong', 'poke…
Master modern web development. Learn HTML/CSS/JavaScript fundamentals, React/Vue/Angular frameworks, Node.js backend, databases, APIs, and full-stack architectures.
Parse EMVCo QR content strings — TLV breakdown, CRC validation, X9.150 URL extraction
Triggers: architecture review, FPF, functional programming framework, systems architecture Architecture review using FPF (Functional Programming Framework) methodology.
Introduce yourself to a newly connected channel. Triggered automatically when a channel is first wired. Send a friendly greeting and brief overview of what you can do.
Multimodal analysis agent for PDF, images, video, audio, charts, and screenshots. Use when: analyzing documents, describing images, analyzing video/audio content, explain — from…
Imputes missing/dropout values in scRNA-seq expression data to improve metabolic pathway analysis. This process handles sparsity common in single-cell RNA sequencing data by…
Apply P4 Lens Shifting to deliberately adopt different interpretive frameworks to reveal hidden aspects.
Documentation generation patterns for technical specs, API docs, user guides, and knowledge bases using real tools like Sphinx, MkDocs, TypeDoc, and Nextra.
AI-optimized web search using Tavily Search API. Use when you need comprehensive web research, current events lookup, domain-specific search, or AI-generated answer summa — from…
Test at extremes (1000x bigger/smaller, instant/year-long) to expose fundamental truths hidden at normal scales — from majiayu000/claude-skill-registry
Guard long, ambiguous, or stateful AI-agent work from drift. Use when the user asks to run or continue a multi-step task, autonomous loop, bug fix, repo change, PR readiness…
Analyze a GitHub issue and create detailed analysis in workflows/
Build agentic systems using Claude CLI in headless mode or the Claude Agent SDK. Use when building automation pipelines, CI/CD integrations, multi-agent orchestration, or — from…
Production observability with tracing, OpenTelemetry, and Prometheus metrics including structured logging, instrumented functions, distributed tracing, health checks, and request…
Analyzes task/feature complexity (1-10) and recommends subtask breakdown for planning and prioritization.