Generate professional clinical decision support (CDS) documents for pharmaceutical and clinical research settings, including patient cohort analyses (biomarker-stratified — from…
Guidelines for clinical decision support (CDS) documents: biomarker-stratified cohort analyses and GRADE-graded treatment reports.
Generate professional clinical decision support (CDS) documents for pharmaceutical and clinical research settings, including patient cohort analyses (biomarker-stratified — from…
Foundations of clinical psychology and psychopathology. Covers anxiety disorders (generalized anxiety, panic, phobias, OCD, PTSD), depressive disorders (major depression,…
Clinical variant interpretation using ClinVar, ACMG guidelines, and pathogenicity predictors. Prioritize variants for diagnostic and research applications.
Write comprehensive clinical reports including case reports (CARE guidelines), diagnostic reports (radiology/pathology/lab), clinical trial reports (ICH-E3, SAE, CSR), an — from…
Use when designing a prospective clinical study before submission — selecting and classifying endpoints (primary / key-secondary / exploratory, with surrogate-endpoint flagging),…
Avoid common methodological mistakes in clinical research with MIMIC-IV and eICU databases. Covers immortal time bias, information leakage, selection bias, and other critical…
Verifies clinical claims and citations: PMID/DOI validity, claim accuracy, and evidence-level wording. Use when the user wants existing content fact-checked.
Batch extracts and verifies structured information (PMID, title, abstract, methodology, results, etc.) from clinical research literature using PMIDs.
Drafts U.S. clinical trial agreements governing sponsor–site–investigator relationships under FDA rules (21 CFR Parts 50, 56, 312) and ICH-GCP E6(R2).
Drafts U.S. clinical trial Investigator Agreements between sponsors/CROs and principal investigators or institutions for FDA-regulated drug, biologic, or device studies.
Generate clinical trial protocols for medical devices or drugs through a modular, waypoint-based architecture with research-only and full protocol modes.
Align CLIP-seq reads to the genome with crosslink site awareness. Use when mapping preprocessed CLIP reads for peak calling. — from science/biology-medicine
Use when you have preprocessed MS/MS spectral data (normalized peak intensities and m/z values) in memory or on disk, a trained CNN model checkpoint available, and you ne — from…
Detect copy number variations from whole genome sequencing data and generate publication-quality genome-wide CNV plots.
Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis.
Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis. — from bg-szy/TOP-SKILLS
Constraint-based (COBRA) analysis of genome-scale metabolic models: FBA, FVA, knockouts, flux sampling, production envelopes, gapfilling, media optimization.
Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis.
Use when you have a set of molecular structures in SMILES format that require CCS prediction for metabolite annotation in untargeted mass spectrometry workflows.
Use when when you have peak-abundance .csv files and assigned molecular formula data from FT-ICR MS preprocessing, and you need to verify that a published pipeline's runtime…
Generates complete comorbidity-oriented shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction.
比较基因组与进化分析 skill。用于 ortholog inference、synteny、whole-genome duplication、positive selection、dN/dS、HGT、ancestral reconstruction、annotation transfer 和跨物种功能比较。
Use when when you have a binned Hi-C cooler file, an associated eigenvector track (from prior eigs_cis calculation), and need to measure how strongly the genome is partitioned…
Use when sharpening the conservation significance and actionable implications of a Conservation Biology manuscript.
Use when building tables, figures, and maps for a Conservation Biology manuscript so exhibits are self-contained, accessible, and respect the journal's exhibit budget (about one…
Use when preparing the data-availability statement and the data/code archive for a Conservation Biology manuscript.
Use when defending the study design of a Conservation Biology manuscript — ecological sampling and inference (detection, spatial structure, pseudoreplication),…
Use when drafting or polishing a Conservation Biology manuscript so it reads accessibly for a broad conservation audience, follows the journal Style Guide, and fits the per-type…
Use when a mass spectrometry analysis pipeline must accept data from multiple sources with different identifier schemes (GNPS Task ID, Universal Spectrum Identifiers, or…
Use when when deploying a complex bioinformatics pipeline (like HiC-Pro) across heterogeneous computing environments where required tools (bowtie2, samtools, R, Python) may be…
Use when after RDKit has generated a large set of 3D conformers for a molecule in SDF or XYZ format, and before submitting conformers to computationally expensive quantum-chemical…
Use when after RDKit has generated a large ensemble of 3D conformers for a molecule (typically hundreds to thousands), you need to reduce computational burden before…
Use when you have SMILES strings of molecules at specific ionization states (e.g., protonated or deprotonated adducts) and need to predict collision cross section values for mass…
Detect contamination and assess genome quality using CheckM, CheckM2, GTDB-Tk, and GUNC for metagenome-assembled genomes and isolate assemblies.
Detect sample contamination and cross-species reads using FastQ Screen. Screen reads against multiple reference genomes to identify bacterial, viral, adapter, or sample s — from…
Use when you have paired MS/MS spectra and molecular structures (SMILES or SDF format) and need to perform compound identification by retrieving the correct structure for an…
Use this agent when you need to synthesize and distill the core functions of a gene from multiple information sources (textual summaries, reviewed annotations, bioinformatics…
Use when when comparing two MS/MS spectra (query and reference) to quantify their spectral resemblance for compound identification or molecular networking, particularly when you…
Use when you have a collection of deconvolved mass spectra (in MGF or mzTab format) from GC-MS analysis and need to group them into a molecular network to identify structural…
Craft CMS 5 front-end Twig development — atomic design, template architecture, component patterns, Vite buildchain.
CRISPR/Base-Editing Einwilligung: moderner Medizinrechts-Skill für Genomeditierung, irreversible Risiken, Off-target-Risiken, Langzeitnachbeobachtung und Aufklärungstiefe:…
Acts as a peer review assistant to evaluate bioinformatics manuscripts. Identifies missing baselines, methodological flaws, and data leakage.
Use when when you have predicted retention times from a DNN model trained on one chromatographic method (CM) and need to rank or filter metabolite candidates on a different…
Use when when cataloging a suite of related bioinformatics tools or web applications (particularly in domains like metabolomics, microbiology, or systems biology) and you need to…
Use when when preparing augmented training data for a Siamese rescore model that must learn to rank correct molecular formulas above incorrect ones;
Use when you have an experimental mass spectrum (query) and a set of molecular candidate structures, and you need to rank the candidates by how well their predicted spectral…
Use when targeting Current Biology or deciding whether a general-biology manuscript fits this venue. Encodes the journal's fit, framing, method-and-evidence bar, house style,…
Design and troubleshoot robust data pipelines with comprehensive quality validation, error handling, and monitoring capabilities for bioinformatics and data processing workflows
Use when you have raw spectroscopic datasets from heterogeneous sources (multiple Zenodo repositories with different file formats and scales) that must be jointly normalized,…
Use when processing spectral datasets from open mass spectra libraries (OMSLs) where structural identifiers and ionization metadata are incomplete or inconsistent.
Search 78 public scientific, biomedical, materials science, and economic databases via REST APIs. Covers physics/astronomy (NASA, NIST, SDSS, SIMBAD), earth/environment (USGS,…
Use when you have mass spectrometry data arriving through heterogeneous input formats (Task ID from GNPS, Universal Spectrum Identifiers, or Feature-Based Molecular Networking…
Use when when you have partitioned public MS/MS files from MassIVE using the ReDU File Selector into one or more filtered groups (G1–G6) and need to verify that each group's file…
Use when when you have unknown MS/MS spectra with observed precursor m/z values and want to infer the molecular formula and adduct type (e.g., [M+H]+, [M+Na]+, [M+K]+) in a de…
Use when when you have high-resolution LC-MS/MS data for an unknown metabolite or small molecule, have computed or measured the molecular ion mass and fragmentation spectrum, and…
Use when you have tandem mass spectra data and need to predict a discrete molecular property (e.g., presence/absence of a sulfo group) while maintaining full interpretability of…
Use when when you have preprocessed MS/MS spectral data (normalized peak intensities and m/z values) and need to convert each spectrum into a learned molecular embedding — from…
Use when you have paired tandem MS/MS spectra with known molecular fingerprints,