Use when you are implementing ORA for metabolomics pathway analysis and must decide which metabolites constitute the statistical background against which to test your experimental…
Use when formulating the model and stating results for an Operations Research (OR) manuscript — defining the optimization/stochastic/simulation model, assumptions, and the…
Use when analyzing differential methylation from bisulfite sequencing data where you suspect overdispersion (variance exceeds binomial expectations), or when comparing uncorrected…
Use when after running DESeq() to fit negative binomial GLMs and obtaining raw p-values from results(dds), when you need to reduce false positives from multiple testing across…
Use when a teacher asks to calculate, reconcile, summarize, or classify student scores, including final grades, mastery, remedial, enrichment, statistics, or an e-Rapor-ready…
Optimize a webpage for traditional search engines (Google, Bing). Covers keyword research, competitor page analysis, on-page SEO audit with scoring, content optimization, and…
Statistical arbitrage tool for identifying and analyzing pair trading opportunities. Detects cointegrated stock pairs within sectors, analyzes spread behavior, calculates — from…
Explore and optimize simulation parameters via design of experiments (DOE), sensitivity analysis, and optimizer selection — generate Latin Hypercube, quasi-random, or factorial…
Reads and transforms Apache Parquet file metadata and column statistics using PyArrow and the Parquet Thrift specification.
Profiles Apache Parquet files using pyarrow metadata APIs to extract column statistics, row group distributions, and encoding efficiency metrics without reading full datasets.
Proactively analyzes Parquet file operations and suggests optimization improvements for compression, encoding, row group sizing, and statistics.
Use when when you have an untargeted metabolomics feature table (m/z values, retention times, intensity measurements, and p-values from statistical testing) and want to p — from…
Use when after marker identification or metabolite annotation has produced a curated list of compound IDs (e.g., KEGG IDs or CAS numbers) and you need to determine which metabolic…
Use when when preparing to run ORA on a metabolomics study: you have a list of detected metabolites from your experiment and need to determine which metabolites from the full…
Use when you have a preranked gene list (e.g., genes sorted by log2 fold-change, t-statistic, or other continuous metric) and a collection of gene sets or biological pathways, and…
Use when you have normalized gene expression data (log-transformed, quantile-normalized) from a time-course or case-control experiment, a ranked gene statistic (e.g., mean…
Conjecture generation, sequence analysis, and experimental mathematics for mathematical discovery. Covers sequence analysis (OEIS lookups, recurrence relations, generating…
Use when after peak detection and before any comparative analysis (e.g., diversity indices, ordination, or statistical testing) when working with direct injection FT-ICR MS data…
Annotate ChIP-seq peaks to genomic features and genes using ChIPseeker. Assign peaks to promoters, exons, introns, and intergenic regions.
Use when after peak detection and clustering have been completed on aligned and baseline-corrected GC-IMS data, and before imputation or statistical analysis.
Use when you have centroided high-resolution Orbitrap or GC-CI-MS mzML files and a formulaTable of target compounds with known m/z, retention time, and molecular formula, and you…
Use when you have completed XCMS preprocessing (getEIC() and fillPeaks()) on untargeted LC-MS metabolomics data and need to assign per-peak quality scores prior to manual…
Use when when you have extracted peak tables from multiple independent LC/HRMS analysis batches (each with retention time and m/z values) and need to align peaks across batches to…
Prompt Engineering Instructional Language (PEIL) - generates optimised system prompts for AI agents and LLMs.
Fetch and report Peloton cycling workout statistics. Use when the user wants to see their Peloton workout data, weekly cycling stats, ride history, or performance metrics.
Penrose is an open-source platform that creates beautiful mathematical and scientific diagrams from plain text notation.
Code instrumentation for timing workloads. Two scenarios: (1) Training loop — inject manual timing to report per-iteration latency, throughput (samples/sec), and data load time.
Performance benchmarking expertise for shell tools, covering benchmark design, statistical analysis (min/max/mean/median/stddev), performance targets (<100ms, >90% hit rate),…
Analyze a specific performance regression against a defined baseline and workload using profiles, benchmarks, traces, logs, or reproducible experiments, covering algorithms, I/O,…
Estimate causal effects from existing data. Use when fitting or interpreting DiD, ITS, synthetic control, regression discontinuity, or other treatment-effect analyses, including…
Automate network traffic analysis using tshark and pyshark for protocol statistics, suspicious flow detection,
Use when after running PERMANOVA on distance matrices derived from FT-ICR MS metabolite peak intensities or other high-dimensional compositional data, when p-values indicate…
Use when you have normalized peak intensities or abundance matrices from mass spectrometry (e.
Highest level of research and reasoning capabilities for complex decision-making with significant consequences, strategic planning, technical architecture decisions,…
Expert personal finance coach with deep knowledge of tax optimization, investment theory (MPT, factor investing), retirement mathematics (Trinity Study, SWR research), and…
The PostgreSQL cumulative-statistics framework — `src/backend/utils/activity/pgstat*.c` (post-PG-15 shared-memory design).
Use when a task needs the judgment of a Physicist — designing an experiment to control systematic error, propagating measurement uncertainty through a derived quantity, evaluating…
Multi-agent web research for any coding agent. Use for anything requiring current information from the internet — news, trends, product/service/company facts, statistics, people,…
Manage and monitor local Pi-hole instance. Query FTL database for statistics (blocked ads, top clients) and control service via CLI.
Use for PixiJS v8 math: Point, ObservablePoint, Matrix, Rectangle, Circle, Ellipse, Polygon, Triangle, hit testing, bounds, toGlobal/toLocal, math-extras.
Measure-don't-guess performance audit across web, mobile, backend, and data layers — produces burndown and optimization plan with no fixes in this pass.
Query and analyze website analytics from Plausible Analytics. Use when you need to check real-time visitors, get page views and visitor statistics for a time period, analyze…
Use when debugging a visual bug, layout issue, CSS problem, rendering issue, broken UI, page-looks-wrong report, or any browser-visible defect.
Interactive visualization with Plotly. 40+ chart types (scatter, line, heatmap, 3D, geographic) with hover, zoom, pan.
Generate quantitative statistics about the PM knowledge system — decision counts by type, health trajectory, sprint velocity, issue resolution rates, enforcement compliance.
Use to enforce PNAS's statistics and reproducibility reporting — n and replication, test choice and assumptions, effect sizes with uncertainty, multiple-comparison control,…
Use as the final preflight before submitting to PNAS — a complete checklist across significance, track, Significance Statement, abstract, classification + keywords, figures,…
Use to enforce PNAS Nexus's statistics and reproducibility reporting — n and replication, test choice and assumptions, effect sizes with uncertainty, multiple-comparison control,…
Use when designing or auditing the analytical "evidence" of an ACM PODS paper — worst-case and average-case analyses, matching upper and lower bounds, dichotomy completeness,…
Use when after extending ChIP sample reads to their predicted fragment length and constructing local lambda bias tracks (incorporating d-scaled, 1 kb, 10 kb, and genome-wide…
Use when a task needs the judgment of a Political Scientist — reading a public-opinion poll or forecast for what it actually supports, designing a comparative or…
Polymarket research and directional trading sub-strategy. Part of paper-trader skill. Research-based probability assessment for directional prediction market trades.
Use when selecting or auditing the method for a Production and Operations Management (POM) manuscript — analytical modeling (optimization, stochastic models, game theory),…
Use when when you have validated link annotations from multiple independent datasets (≥2), individual scoring functions with per-dataset enrichment p-values, and you want to test…
群体遗传与 GWAS skill。用于 PLINK/VCF QC、PCA、admixture、LD pruning、association testing、GWAS summary stats、selection statistics、Manhattan/QQ、Fst、Tajima D、iHS 和 XP-EHH 交接。
Extract, analyze, and summarize simulation output data — pull spatial fields at specific timesteps, compute time-series trends and detect steady state, extract line profiles…
Analyze experiment results and generate discussion paragraphs for academic papers. Two-phase workflow: identify measurable findings (Phase 1), confirm with user, then generate…
Produce maintainer-facing statistics about open pull requests on the configured `
` repo (default: read from `/project.md → upstream_repo`).
Convert an existing runnable computer-based research project into a formal Praxist task project, or repair a task harness that fails task-init validation.
Lightweight 5-gate pre-dev workflow for small features (<2 days). Orchestrates topology discovery, research, PRD with UX validation, design validation, TRD, task breakdown, and…