Trauma-informed AI moderator for addiction recovery communities. Applies harm reduction principles, honors 12-step traditions, distinguishes healthy conflict from abuse, detects…
Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis.
Find homologous sequences using iterative BLAST (PSI-BLAST), profile HMMs (HMMER), and reciprocal best hit analysis.
Detects and removes infostealer malware (credential stealers, data exfiltrators) via full-system file search, cryptographic hashing, and public threat-intelligence cross-checks…
Migrate prompts and code from Claude Sonnet 4.0, Sonnet 4.5, or Opus 4.1 to Opus 4.5. Use when the user wants to update their codebase, prompts, or API calls to use Opus — from…
Comprehensive backend development guide for Node.js/Express/TypeScript microservices. Use when creating routes, controllers, services, repositories, middleware, or workin — from…
Game art principles. Visual style selection, asset pipeline, animation workflow. — from bg-szy/TOP-SKILLS
Two services in one skill: (1) Web3 on-chain data via Chainbase CLI — use when the user asks about blockchain data, token holders, wallet addresses, token prices, ENS dom — from…
Review final-assignment materials for requirements, citations, AI-use disclosure, and data-analysis completeness.
Comprehensive frontend development skill for building modern, performant web applications using ReactJS, NextJS, TypeScript, Tailwind CSS.
When the user wants to create, optimize, or audit customer stories or case study pages. Also use when the user mentions "case studies," "customer stories," "success stories,"…
Deploy applications and websites to Vercel instantly. Use when asked to \"Deploy my app\", \"Deploy this to production\", \"Create a preview deployment\", or \"Push this live\".
\"Declarative UI widgets from JSON for React/Next.js from ui.inference.sh. Render rich interactive UIs from structured agent responses.
Advanced single-cell multi-omics analysis including scRNA-seq, scCITE-seq, scATAC-seq, and TARGET-seq.
Run 250+ AI apps via inference.sh CLI - image generation, video creation, LLMs, search, 3D, Twitter automation.
Detect A/B compartments from Hi-C data using cooltools and eigenvector decomposition. Identify active (A) and inactive (B) chromatin compartments from contact matrices.
Use when facing 2+ independent tasks that can be worked on without shared state or sequential dependencies — from bg-szy/TOP-SKILLS
Comprehensive code review skill for TypeScript, JavaScript, Python, Swift, Kotlin, Go. Includes automated code analysis, best practice checking, security scanning, and re — from…
Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 with `bam_ip` + `bam_input` (control arm) and `bam_treated_ip` +…
Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and…
Unified Python interface to 40+ bioinformatics services. Use when querying multiple databases (UniProt, KEGG, ChEMBL, Reactome) in a single workflow with consistent API — from…
Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools.
Run omicverse's CellPhoneDB v5 wrapper on annotated single-cell data to infer ligand-receptor networks and produce CellChat-style visualisations. — from bg-szy/TOP-SKILLS
Nominates and assesses CRISPR off-target sites genome-wide. Enumerates candidate sites by mismatch and bulge tolerance with Cas-OFFinder/CRISPRitz, ranks them with the published…
Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance),…
Targeted metabolomics analysis using MRM/SRM with standard curves. Covers absolute quantification, method validation, and quality assessment.
Build production-ready Node.js backend services with Express/Fastify, implementing middleware patterns, error handling, authentication, database integration, and API desi — from…
Use when receiving code review feedback, before implementing suggestions, especially if feedback seems unclear or technically questionable - requires technical rigor and — from…
Quality control for long-read sequencing data using NanoPlot, NanoStat, and chopper. Generate QC reports, filter reads by length and quality, and visualize read character — from…
Bootstrap a structured research project on any topic — generate an initial items list and research-field schema from model knowledge, supplement with up-to-date web search, then…
End-to-end 16S amplicon workflow from FASTQ reads to differential abundance. Orchestrates DADA2 ASV inference, taxonomy assignment, diversity analysis, and compositional — from…
Create SEO-optimized marketing content with consistent brand voice. Includes brand voice analyzer, SEO optimizer, content frameworks, and social media templates.
Organizational coding standards and architectural patterns. References comprehensive skills for detailed patterns. Use when making architecture decisions or implementing features.
Integrate Firebase AI Logic (Gemini in Firebase) for intelligent app features. Use when adding AI capabilities to Firebase apps, implementing generative AI features, or setting up…
Retrieves chemical compound information from PubChem and ChEMBL with disambiguation, cross-referencing, and quality assessment.
Use when Codex, Hermes, OpenClaw, Claude Code, Cowork, or another AI agent needs to plan, review, implement, audit, or improve email work focused on editorial calendars — from…
Create and manage Claude Code skills with auto-activation, progressive disclosure, and memory patterns.
Give an AI agent its own real browser over MCP tool calls - launch, navigate, click, fill, screenshot, extract text, run JS - with a kernel-level real-device fingerprint and a…
End-to-end neoantigen discovery from somatic variants to ranked vaccine candidates. Integrates HLA typing, MHC binding prediction, pVACtools neoantigen calling, and immun — from…
Visualize enrichment results using enrichplot package functions. Use when creating publication-quality figures from clusterProfiler results.
ChIP-seq peak calling using MACS3 (or MACS2). Call narrow peaks for transcription factors or broad peaks for histone modifications.
Reads, queries, and writes bigWig indexed binary signal tracks (coverage, fold-change, conservation, methylation-rate) with pyBigWig (Python) and the UCSC Kent tools…
End-to-end copy number variant detection workflow from BAM files. Covers CNVkit analysis for exome/targeted sequencing with visualization and annotation.
Assign cells to their sample of origin from cell or nucleus hashing (CITE-seq HTOs, MULTI-seq lipid/cholesterol tags, CellPlex CMOs) and call cross-sample doublets using Seurat…
Character consistency across AI-generated images with reference sheets and LoRA techniques. Covers turnaround views, expression sheets, color palettes, and style consiste — from…
Integrate multiple scRNA-seq samples/batches using Harmony, scVI, Seurat anchors, and fastMNN. Remove technical variation while preserving biological differences.
支付工程师 Agent — 覆盖支付系统架构设计、渠道对接、交易核心开发、对账清算、风控安全、性能优化全流程。支持 Java/Go/Python 技术栈，深度使用分布式中间件。
Call SNPs and indels from aligned reads using bcftools mpileup and call. Use when detecting variants from BAM files or generating VCF from alignments. — from bg-szy/TOP-SKILLS
將提示詞和程式碼從 Claude Sonnet 4.0、Sonnet 4.5 或 Opus 4.1 遷移至 Opus 4.5。當使用者想要更新其程式碼庫、提示詞或 API 呼叫以使用 Opus 4.5 時使用。處理模型字串更新和針對已知 Opus 4.5 行為差異的提示詞調整。不會遷移 Haiku 4.5。 — from bg-szy/TOP-SKILLS
When the user wants to create, optimize, or audit a careers or jobs page. Also use when the user mentions "careers," "jobs," "hiring," "open positions," "company culture,"…
Use when you have a written implementation plan to execute in a separate session with review checkpoints — from bg-szy/TOP-SKILLS
Query NCBI Gene via E-utilities/Datasets API. Search by symbol/ID, retrieve gene info (RefSeqs, GO, locations, phenotypes), batch lookups, for gene annotation and functio — from…
When the user wants to create, optimize, or audit resources page or content hub. Also use when the user mentions "resources page," "resource center," "content hub," "learning…
BNB Chain MCP server connection and tool usage. Covers npx @bnb-chain/mcp@latest, PRIVATE_KEY and RPC, and every MCP tool — blocks, transactions, contracts, ERC20/NFT tra — from…
Generate pileup data for variant calling using samtools mpileup and pysam. Use when preparing data for variant calling, analyzing per-position read data, or calculating a — from…
Biomedical OS Core & MCP Server
CloudBase Node SDK auth guide for server-side identity, user lookup, and custom login tickets. This skill should be used when Node.js code must read caller identity, inspect end…
Design and implement RESTful API endpoints following REST principles, HTTP standards, and resource-based URL conventions.
Fixes broken decks/PDFs exported from Claude's \"Design\" feature (or similar AI deck generators) — cut-off or clipped text, wrong/substituted fonts, and corrupted .pptx package…
Guide for creating effective skills. This skill should be used when users want to create a new skill (or update an existing skill) that extends Claude's capabilities with — from…