ClaudSkills / Science & Research / biology-medicine

Alphagenome

Q: What is a Claude Code skill and how does the Alphagenome skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Alphagenome is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at https://claudskills.com/learn/what-is-skill-md/.

Category: Science & Research · Sub-category: biology-medicine · Last updated: 2026-09-28

Look up precomputed AlphaGenome Atlas effects for any GRCh38 single-nucleotide variant (AVI score with Phred and 18 SHAP feature attributions, plus raw and quantile scores for RNA-seq, DNase, ATAC, ChIP-TF, ChIP-histone, CAGE, PRO-cap, splicing, polyadenylation and contact-map tracks), score variants or scan windows on demand with the AlphaGenome model for human and mouse (variant scoring, in silico mutagenesis, REF-versus-ALT track prediction), and build Atlas website deep links. Use when the user mentions AlphaGenome, AlphaGenome Atlas, AVI or AlphaGenome Variant Impact, DeepMind variant effect prediction, or wants to prioritise or mechanistically interpret non-coding, regulatory, splicing, enhancer, promoter, or chromatin-accessibility effects of SNVs from a VCF, credible set, or region. Research use only; not a clinical tool.

Security AStatic scan found no risk patternsHow grading works ›

About this skill (catalog notes)

Alphagenome includes a dedicated installation section; pricing or quota commentary; 8 code blocks for direct copy-paste. At roughly 1,793 words the SKILL.md is on the longer end of the catalog distribution.

Source: arxiv.org/abs/2609.00065
License: MIT
Original author: K-Dense-AI
Indexed lastmod: 2026-09-28
Catalog position: Science & Research · biology-medicine
Indexed related skills: 10

How Alphagenome fits the catalog

Alphagenome sits in the Science & Research category under the biology-medicine sub-topic in the ClaudSkills catalog. There are 10 related skills indexed alongside it; comparing a few before installing usually reveals which fits your workflow best.

Is Alphagenome safe to install?

A free static scan against the OWASP Agentic Skills Top 10 found no risk patterns in Alphagenome’s SKILL.md — no data-exfiltration, prompt-injection, or unexpected-execution signatures. The full security scan is below.

Installing & verifying

Installing Alphagenome writes its SKILL.md to ~/.claude/skills/alphagenome/SKILL.md; Claude Code discovers it automatically on the next session — no restart flag needed. It declares no allowed-tools restriction, so it inherits your session’s existing tool access rather than narrowing it. To confirm it loaded, ask Claude to list its available skills — alphagenome should appear by name.

What Alphagenome needs to run

External services: The SKILL.md references pricing, quota, or rate limits — it likely calls a paid or rate-limited API. Check the source before wiring it into unattended automation.
Prerequisites: Ships its own installation / prerequisites section — it isn’t purely self-contained; read that first.
Worked code: 8 copy-paste code blocks in the body.
Depth: ~1,793 words, substantial — top of the catalog distribution.

When to reach for it

There are 10 related skills in Science & Research — a two-minute scan of the alternatives usually confirms whether Alphagenome is the right pick.

These notes are auto-generated from features detected in the SKILL.md file and from this catalog's structure — they aren't part of the source repository.

From the source SKILL.md

AlphaGenome is DeepMind's sequence-to-function model: 1 Mb of DNA in, base-pair predictions for eleven assay types across thousands of human and mouse tracks out. The AlphaGenome Atlas (released 2026-09-08) is that model run once over every possible single-nucleotide change in GRCh38, about 9 billion variants, stored with a single ranking number, the AlphaGenome Variant Impact (AVI) score, its genome-wide percentile, and an 18-way attribution of what drives it. Both are reached through one pip install alphagenome and one API key.

What this skill does

Alphagenome is a community-contributed Claude Code skill in the biology-medicine sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/alphagenome/ and loads when your prompt matches the skill's trigger.

When to invoke it: Use when the user mentions AlphaGenome, AlphaGenome Atlas, AVI or AlphaGenome Variant Impact, DeepMind variant effect prediction, or wants to prioritise or mechanistically interpret non-coding, regulatory, splicing, enhancer, promoter, or chromatin-accessibility effects of SNVs from a VCF, credible set, or region. Research use only; not a clinical tool.

Who uses this skill

The Alphagenome Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 196,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/alphagenome
curl -L https://claudskills.com/skills/alphagenome/SKILL.md \
  -o ~/.claude/skills/alphagenome/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/alphagenome/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/alphagenome/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\alphagenome\SKILL.md on Windows. See the full install guide for step-by-step instructions.

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Alphagenome Claude Code skill?

Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/alphagenome/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.

What does the Alphagenome skill do?

Is this skill free to install?

Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.

When should I use the Alphagenome skill?

Use Alphagenome when your Claude Code task falls under the Science & Research category — specifically in the biology medicine area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Alphagenome" or describe the task and let Claude pick). Browse related skills at /category/science/.

What is a Claude Code skill and how does the Alphagenome skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Alphagenome is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Source: https://github.com/K-Dense-AI/scientific-agent-skills/blob/HEAD/skills/alphagenome/SKILL.md
License: MIT
Author: K-Dense-AI
Website: https://arxiv.org/abs/2609.00065

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA

K-Dense-AI. (2026). Alphagenome [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/alphagenome/

BibTeX

@misc{alphagenome-2026,
  author    = {K-Dense-AI},
  title     = {Alphagenome [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/alphagenome/}
}

Embed this skill

Promote, attribute, or link this skill from your own README, blog post, or documentation. All three snippets are free to use — no sign-up, no API key. More distribution surfaces →

Badge

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Security scan

Grade A · scanned 2026-09-28 — free static scan against the OWASP Agentic Skills Top 10.

No risk patterns were found in any of the ten OWASP-aligned categories. How grading works ›

✓ Prompt injection
✓ Data exfiltration
✓ Supply chain
✓ Reverse shell
✓ Credentials
✓ Execution
✓ Filesystem
✓ Persistence
✓ Obfuscation
✓ Network

Show this grade on your repo (click to copy):

[![Security: A](https://img.shields.io/badge/Security-A-2e7d32)](https://claudskills.com/skills/alphagenome/#security)

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Browse all Science & Research skills → Top 100 skills

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