ClaudSkills / Science & Research / biology-medicine

Bio Comparative Genomics Ancestral Reconstruction

Q: What is a Claude Code skill and how does the Bio Comparative Genomics Ancestral Reconstruction skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Comparative Genomics Ancestral Reconstruction is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at https://claudskills.com/learn/what-is-skill-md/.

Category: Science & Research · Sub-category: biology-medicine · Last updated: 2026-06-02

Reconstruct ancestral states at internal phylogenetic nodes for sequences (PAML codeml, IQ-TREE --ancestral, GRASP, FastML), discrete traits (corHMM hidden-rate Markov, ape::ace, phytools::make.simmap stochastic mapping, BayesTraits), and continuous traits (phytools::fastAnc, geiger Brownian/OU, RPANDA). Use when designing constructs for ancestral protein resurrection, tracing trait evolution along a tree, performing stochastic character mapping, testing models of trait evolution (BM vs OU vs EB), inferring ancestral genome content via Dollo or DTL reconciliation, or quantifying ancestral-state uncertainty for downstream comparative analyses.

What this skill does

Bio Comparative Genomics Ancestral Reconstruction is a community-contributed Claude Code skill in the biology-medicine sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-comparative-genomics-ancestral-reconstruction/ and loads when your prompt matches the skill's trigger.

When to invoke it: Use when designing constructs for ancestral protein resurrection, tracing trait evolution along a tree, performing stochastic character mapping, testing models of trait evolution (BM vs OU vs EB), inferring ancestral genome content via Dollo or DTL reconciliation, or quantifying ancestral-state uncertainty for downstream comparative analyses.

Who uses this skill

The Bio Comparative Genomics Ancestral Reconstruction Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 93,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/bio-comparative-genomics-ancestral-reconstruction
curl -L https://claudskills.com/skills/bio-comparative-genomics-ancestral-reconstruction/SKILL.md \
  -o ~/.claude/skills/bio-comparative-genomics-ancestral-reconstruction/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-comparative-genomics-ancestral-reconstruction/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/bio-comparative-genomics-ancestral-reconstruction/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-comparative-genomics-ancestral-reconstruction\SKILL.md on Windows. See the full install guide for step-by-step instructions.

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Bio Comparative Genomics Ancestral Reconstruction Claude Code skill?

Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/bio-comparative-genomics-ancestral-reconstruction/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.

What does the Bio Comparative Genomics Ancestral Reconstruction skill do?

Is this skill free to install?

Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.

When should I use the Bio Comparative Genomics Ancestral Reconstruction skill?

Use Bio Comparative Genomics Ancestral Reconstruction when your Claude Code task falls under the Science & Research category — specifically in the biology medicine area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Bio Comparative Genomics Ancestral Reconstruction" or describe the task and let Claude pick). Browse related skills at /category/science/.

What is a Claude Code skill and how does the Bio Comparative Genomics Ancestral Reconstruction skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Comparative Genomics Ancestral Reconstruction is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Source: https://github.com/bg-szy/TOP-SKILLS/blob/HEAD/skills/awesome-skills/bio-comparative-genomics-ancestral-reconstruction/SKILL.md
Author: bg-szy
Website: https://bg-szy.github.io/TOP-SKILLS/

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA

bg-szy. (2026). Bio Comparative Genomics Ancestral Reconstruction [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/bio-comparative-genomics-ancestral-reconstruction/

BibTeX

@misc{bio-comparative-genomics-ancestral-reconstruction-2026,
  author    = {bg-szy},
  title     = {Bio Comparative Genomics Ancestral Reconstruction [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/bio-comparative-genomics-ancestral-reconstruction/}
}

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