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Bio Comparative Genomics Comparative Annotation Projection

Category: Science & Research  ·  Sub-category: biology-medicine  ·  Last updated:
Project gene annotations across genomes using TOGA (Kirilenko 2023 whole-genome-alignment chain-based projection with intactness classification), CESAR 2.0 (Sharma & Hiller 2017 codon-aware exon projection), LiftOff (Shumate & Salzberg 2020 reference-based annotation transfer), Liftover (UCSC), GeMoMa (Keilwagen 2019 evidence-based projection), and Comparative Annotation Toolkit (CAT). Use when transferring annotations from a well-annotated reference to query genome(s), classifying gene-loss vs gene-intact across many genomes at scale, building Zoonomia-style comparative annotations across hundreds of mammals or birds (Kirilenko 2023), detecting pseudogenization, projecting alternative isoforms, or selecting between WGA-anchored (TOGA) vs ortholog-based (LiftOff) annotation transfer strategies.

About this skill (catalog notes)

Bio Comparative Genomics Comparative Annotation Projection includes a dedicated installation section; 5 code blocks for direct copy-paste. At roughly 3,634 words the SKILL.md is on the longer end of the catalog distribution.

Source
bg-szy.github.io/TOP-SKILLS
Original author
bg-szy
Indexed lastmod
Catalog position
Science & Research · biology-medicine
Indexed related skills
10

How Bio Comparative Genomics Comparative Annotation Projection fits the catalog

Bio Comparative Genomics Comparative Annotation Projection sits in the Science & Research category under the biology-medicine sub-topic in the ClaudSkills catalog. There are 10 related skills indexed alongside it; comparing a few before installing usually reveals which fits your workflow best.

These notes are auto-generated from features detected in the SKILL.md file and from this catalog's structure — they aren't part of the source repository.

What this skill does

Bio Comparative Genomics Comparative Annotation Projection is a community-contributed Claude Code skill in the biology-medicine sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-comparative-genomics-comparative-annotation-projection/ and loads when your prompt matches the skill's trigger.

When to invoke it: Use when transferring annotations from a well-annotated reference to query genome(s), classifying gene-loss vs gene-intact across many genomes at scale, building Zoonomia-style comparative annotations across hundreds of mammals or birds (Kirilenko 2023), detecting pseudogenization, projecting alternative isoforms, or selecting between WGA-anchored (TOGA) vs ortholog-based (LiftOff) annotation transfer strategies.

Who uses this skill

The Bio Comparative Genomics Comparative Annotation Projection Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 93,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/bio-comparative-genomics-comparative-annotation-projection
curl -L https://claudskills.com/skills/bio-comparative-genomics-comparative-annotation-projection/SKILL.md \
  -o ~/.claude/skills/bio-comparative-genomics-comparative-annotation-projection/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-comparative-genomics-comparative-annotation-projection/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/bio-comparative-genomics-comparative-annotation-projection/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-comparative-genomics-comparative-annotation-projection\SKILL.md on Windows. See the full install guide for step-by-step instructions.

Telegram

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

Frequently asked questions

How do I install the Bio Comparative Genomics Comparative Annotation Projection Claude Code skill?
Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/bio-comparative-genomics-comparative-annotation-projection/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.
What does the Bio Comparative Genomics Comparative Annotation Projection skill do?
Project gene annotations across genomes using TOGA (Kirilenko 2023 whole-genome-alignment chain-based projection with intactness classification), CESAR 2.0 (Sharma & Hiller 2017 codon-aware exon projection), LiftOff (Shumate & Salzberg 2020 reference-based annotation transfer), Liftover (UCSC), GeMoMa (Keilwagen 2019 evidence-based projection), and Comparative Annotation Toolkit (CAT). Use when transferring annotations from a well-annotated reference to query genome(s), classifying gene-loss vs gene-intact across many genomes at scale, building Zoonomia-style comparative annotations across hundreds of mammals or birds (Kirilenko 2023), detecting pseudogenization, projecting alternative isoforms, or selecting between WGA-anchored (TOGA) vs ortholog-based (LiftOff) annotation transfer strategies.
Is this skill free to install?
Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.
When should I use the Bio Comparative Genomics Comparative Annotation Projection skill?
Use Bio Comparative Genomics Comparative Annotation Projection when your Claude Code task falls under the Science & Research category — specifically in the biology medicine area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Bio Comparative Genomics Comparative Annotation Projection" or describe the task and let Claude pick). Browse related skills at /category/science/.
What is a Claude Code skill and how does the Bio Comparative Genomics Comparative Annotation Projection skill fit in?
A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Comparative Genomics Comparative Annotation Projection is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA
bg-szy. (2026). Bio Comparative Genomics Comparative Annotation Projection [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/bio-comparative-genomics-comparative-annotation-projection/
BibTeX
@misc{bio-comparative-genomics-comparative-annotation-projection-2026,
  author    = {bg-szy},
  title     = {Bio Comparative Genomics Comparative Annotation Projection [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/bio-comparative-genomics-comparative-annotation-projection/}
}

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