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Bio Copy Number Hrd Scoring

Category: Content  ·  Sub-category: content-misc  ·  Last updated:
lang:python
Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.

What this skill does

Bio Copy Number Hrd Scoring is a community-contributed Claude Code skill in the content-misc sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-copy-number-hrd-scoring/ and loads when your prompt matches the skill's trigger.

When to invoke it: Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.

Who uses this skill

The Bio Copy Number Hrd Scoring Claude Code skill is built for content creators, marketers, copywriters, SEO professionals, and editorial teams. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 116,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/bio-copy-number-hrd-scoring
curl -L https://claudskills.com/skills/bio-copy-number-hrd-scoring/SKILL.md \
  -o ~/.claude/skills/bio-copy-number-hrd-scoring/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-copy-number-hrd-scoring/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/bio-copy-number-hrd-scoring/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-copy-number-hrd-scoring\SKILL.md on Windows. See the full install guide for step-by-step instructions.

Telegram

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Bio Copy Number Hrd Scoring Claude Code skill?
Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/bio-copy-number-hrd-scoring/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.
What does the Bio Copy Number Hrd Scoring skill do?
Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.
Is this skill free to install?
Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.
When should I use the Bio Copy Number Hrd Scoring skill?
Use Bio Copy Number Hrd Scoring when your Claude Code task falls under the Content category — specifically in the content misc area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Bio Copy Number Hrd Scoring" or describe the task and let Claude pick). Browse related skills at /category/content/.
What is a Claude Code skill and how does the Bio Copy Number Hrd Scoring skill fit in?
A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Copy Number Hrd Scoring is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Content category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA
bg-szy. (2026). Bio Copy Number Hrd Scoring [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/bio-copy-number-hrd-scoring/
BibTeX
@misc{bio-copy-number-hrd-scoring-2026,
  author    = {bg-szy},
  title     = {Bio Copy Number Hrd Scoring [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/bio-copy-number-hrd-scoring/}
}

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