ClaudSkills / Science & Research / biology-medicine

Bio Crispr Screens Combinatorial Screens

Q: What is a Claude Code skill and how does the Bio Crispr Screens Combinatorial Screens skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Crispr Screens Combinatorial Screens is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at https://claudskills.com/learn/what-is-skill-md/.

Category: Science & Research · Sub-category: biology-medicine · Last updated: 2026-06-02

Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

About this skill (catalog notes)

Bio Crispr Screens Combinatorial Screens includes pricing or quota commentary; at least one code block. At roughly 2,121 words the SKILL.md is on the longer end of the catalog distribution.

Source: bg-szy.github.io/TOP-SKILLS
Original author: bg-szy
Indexed lastmod: 2026-06-02
Catalog position: Science & Research · biology-medicine
Indexed related skills: 10

How Bio Crispr Screens Combinatorial Screens fits the catalog

Bio Crispr Screens Combinatorial Screens sits in the Science & Research category under the biology-medicine sub-topic in the ClaudSkills catalog. There are 10 related skills indexed alongside it; comparing a few before installing usually reveals which fits your workflow best.

These notes are auto-generated from features detected in the SKILL.md file and from this catalog's structure — they aren't part of the source repository.

What this skill does

Bio Crispr Screens Combinatorial Screens is a community-contributed Claude Code skill in the biology-medicine sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-crispr-screens-combinatorial-screens/ and loads when your prompt matches the skill's trigger.

When to invoke it: Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

Who uses this skill

The Bio Crispr Screens Combinatorial Screens Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 93,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/bio-crispr-screens-combinatorial-screens
curl -L https://claudskills.com/skills/bio-crispr-screens-combinatorial-screens/SKILL.md \
  -o ~/.claude/skills/bio-crispr-screens-combinatorial-screens/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-crispr-screens-combinatorial-screens/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/bio-crispr-screens-combinatorial-screens/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-crispr-screens-combinatorial-screens\SKILL.md on Windows. See the full install guide for step-by-step instructions.

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Bio Crispr Screens Combinatorial Screens Claude Code skill?

Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/bio-crispr-screens-combinatorial-screens/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.

What does the Bio Crispr Screens Combinatorial Screens skill do?

Is this skill free to install?

Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.

When should I use the Bio Crispr Screens Combinatorial Screens skill?

Use Bio Crispr Screens Combinatorial Screens when your Claude Code task falls under the Science & Research category — specifically in the biology medicine area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Bio Crispr Screens Combinatorial Screens" or describe the task and let Claude pick). Browse related skills at /category/science/.

What is a Claude Code skill and how does the Bio Crispr Screens Combinatorial Screens skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Crispr Screens Combinatorial Screens is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Source: https://github.com/bg-szy/TOP-SKILLS/blob/HEAD/skills/awesome-skills/bio-crispr-screens-combinatorial-screens/SKILL.md
Author: bg-szy
Website: https://bg-szy.github.io/TOP-SKILLS/

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA

bg-szy. (2026). Bio Crispr Screens Combinatorial Screens [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/bio-crispr-screens-combinatorial-screens/

BibTeX

@misc{bio-crispr-screens-combinatorial-screens-2026,
  author    = {bg-szy},
  title     = {Bio Crispr Screens Combinatorial Screens [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/bio-crispr-screens-combinatorial-screens/}
}

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