bio-crispr-screens-hit-calling
Cross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.
Security AStatic scan found no risk patternsHow grading works ›
What this skill does
bio-crispr-screens-hit-calling is a community-contributed Claude Code skill in the math-stats sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-crispr-screens-hit-calling--skills-hit-calling/ and loads when your prompt matches the skill's trigger.
When to invoke it: Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.
Who uses this skill
The bio-crispr-screens-hit-calling Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 161,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).
How to install
Free
Manual install (2 steps)
mkdir -p ~/.claude/skills/bio-crispr-screens-hit-calling--skills-hit-calling
curl -L https://claudskills.com/skills/bio-crispr-screens-hit-calling--skills-hit-calling/SKILL.md \
-o ~/.claude/skills/bio-crispr-screens-hit-calling--skills-hit-calling/SKILL.md
Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-crispr-screens-hit-calling--skills-hit-calling/. Claude Code auto-discovers it on next session.
Skills live at ~/.claude/skills/bio-crispr-screens-hit-calling--skills-hit-calling/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-crispr-screens-hit-calling--skills-hit-calling\SKILL.md on Windows. See the full install guide for step-by-step instructions.
Telegram
📱 Install from your phone or desktop Telegram
Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →
Pro
One-click install via the desktop app
The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.
Pro
For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.
Frequently asked questions
How do I install the bio-crispr-screens-hit-calling Claude Code skill?
Install via the ClaudSkills desktop app (one click) or copy
SKILL.md from the source repository to
~/.claude/skills/bio-crispr-screens-hit-calling--skills-hit-calling/SKILL.md and restart Claude Code. Both flows are detailed at
claudskills.com/install/.
What does the bio-crispr-screens-hit-calling skill do?
Cross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.
Is this skill free to install?
Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.
When should I use the bio-crispr-screens-hit-calling skill?
Use bio-crispr-screens-hit-calling when your Claude Code task falls under the Science & Research category — specifically in the math stats area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use bio-crispr-screens-hit-calling" or describe the task and let Claude pick). Browse related skills at
/category/science/.
What is a Claude Code skill and how does the bio-crispr-screens-hit-calling skill fit in?
A Claude Code skill is a
SKILL.md file that lives under
~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. bio-crispr-screens-hit-calling is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at
/learn/what-is-a-claude-skill/.
Attribution & license
Cite this skill
If you reference this skill in a blog post, paper, or documentation, you can cite it as:
APA
bg-szy. (2026). bio-crispr-screens-hit-calling [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/bio-crispr-screens-hit-calling--skills-hit-calling/
BibTeX
@misc{bio-crispr-screens-hit-calling--skills-hit-calling-2026,
author = {bg-szy},
title = {bio-crispr-screens-hit-calling [Claude Code skill]},
year = {2026},
publisher = {ClaudSkills},
url = {https://claudskills.com/skills/bio-crispr-screens-hit-calling--skills-hit-calling/}
}Embed this skill
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Security scan
Grade A · scanned 2026-07-26 — free static scan against the OWASP Agentic Skills Top 10.
No risk patterns were found in any of the ten OWASP-aligned categories. How grading works ›
- ✓ Prompt injection
- ✓ Data exfiltration
- ✓ Supply chain
- ✓ Reverse shell
- ✓ Credentials
- ✓ Execution
- ✓ Filesystem
- ✓ Persistence
- ✓ Obfuscation
- ✓ Network
Show this grade on your repo (click to copy):
[](https://claudskills.com/skills/bio-crispr-screens-hit-calling--skills-hit-calling/#security)
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