Category:Science & Research · Sub-category: biology-medicine · Last updated:
Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.
About this skill (catalog notes)
bio-crispr-screens-jacks-analysis includes 5 code blocks for direct copy-paste. At roughly 2,122 words the SKILL.md is on the longer end of the catalog distribution.
How bio-crispr-screens-jacks-analysis fits the catalog
bio-crispr-screens-jacks-analysis sits in the Science & Research category under the biology-medicine sub-topic in the ClaudSkills catalog. There are 10 related skills indexed alongside it; comparing a few before installing usually reveals which fits your workflow best.
These notes are auto-generated from features detected in the SKILL.md file and from this catalog's structure — they aren't part of the source repository.
What this skill does
bio-crispr-screens-jacks-analysis is a community-contributed Claude Code skill in the biology-medicine sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-crispr-screens-jacks-analysis--skills-jacks-analysis/ and loads when your prompt matches the skill's trigger.
When to invoke it: Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.
Who uses this skill
The bio-crispr-screens-jacks-analysis Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 93,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).
Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-crispr-screens-jacks-analysis--skills-jacks-analysis/. Claude Code auto-discovers it on next session.
Skills live at ~/.claude/skills/bio-crispr-screens-jacks-analysis--skills-jacks-analysis/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-crispr-screens-jacks-analysis--skills-jacks-analysis\SKILL.md on Windows. See the full install guide for step-by-step instructions.
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One-click install via the desktop app
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How do I install the bio-crispr-screens-jacks-analysis Claude Code skill?
Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/bio-crispr-screens-jacks-analysis--skills-jacks-analysis/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.
What does the bio-crispr-screens-jacks-analysis skill do?
Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.
Is this skill free to install?
Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.
When should I use the bio-crispr-screens-jacks-analysis skill?
Use bio-crispr-screens-jacks-analysis when your Claude Code task falls under the Science & Research category — specifically in the biology medicine area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use bio-crispr-screens-jacks-analysis" or describe the task and let Claude pick). Browse related skills at /category/science/.
What is a Claude Code skill and how does the bio-crispr-screens-jacks-analysis skill fit in?
A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. bio-crispr-screens-jacks-analysis is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.
@misc{bio-crispr-screens-jacks-analysis--skills-jacks-analysis-2026,
author = {bg-szy},
title = {bio-crispr-screens-jacks-analysis [Claude Code skill]},
year = {2026},
publisher = {ClaudSkills},
url = {https://claudskills.com/skills/bio-crispr-screens-jacks-analysis--skills-jacks-analysis/}
}
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