Category:Science & Research · Sub-category: science-misc · Last updated:
Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.
About this skill (catalog notes)
bio-crispr-screens-mageck-analysis includes worked examples; 9 code blocks for direct copy-paste. At roughly 3,049 words the SKILL.md is on the longer end of the catalog distribution.
How bio-crispr-screens-mageck-analysis fits the catalog
bio-crispr-screens-mageck-analysis sits in the Science & Research category under the science-misc sub-topic in the ClaudSkills catalog. There are 10 related skills indexed alongside it; comparing a few before installing usually reveals which fits your workflow best.
These notes are auto-generated from features detected in the SKILL.md file and from this catalog's structure — they aren't part of the source repository.
What this skill does
bio-crispr-screens-mageck-analysis is a community-contributed Claude Code skill in the science-misc sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-crispr-screens-mageck-analysis--skills-mageck-analysis/ and loads when your prompt matches the skill's trigger.
When to invoke it: Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.
Who uses this skill
The bio-crispr-screens-mageck-analysis Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 116,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).
Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-crispr-screens-mageck-analysis--skills-mageck-analysis/. Claude Code auto-discovers it on next session.
Skills live at ~/.claude/skills/bio-crispr-screens-mageck-analysis--skills-mageck-analysis/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-crispr-screens-mageck-analysis--skills-mageck-analysis\SKILL.md on Windows. See the full install guide for step-by-step instructions.
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One-click install via the desktop app
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How do I install the bio-crispr-screens-mageck-analysis Claude Code skill?
Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/bio-crispr-screens-mageck-analysis--skills-mageck-analysis/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.
What does the bio-crispr-screens-mageck-analysis skill do?
Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.
Is this skill free to install?
Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.
When should I use the bio-crispr-screens-mageck-analysis skill?
Use bio-crispr-screens-mageck-analysis when your Claude Code task falls under the Science & Research category — specifically in the science misc area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use bio-crispr-screens-mageck-analysis" or describe the task and let Claude pick). Browse related skills at /category/science/.
What is a Claude Code skill and how does the bio-crispr-screens-mageck-analysis skill fit in?
A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. bio-crispr-screens-mageck-analysis is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.
@misc{bio-crispr-screens-mageck-analysis--skills-mageck-analysis-2026,
author = {bg-szy},
title = {bio-crispr-screens-mageck-analysis [Claude Code skill]},
year = {2026},
publisher = {ClaudSkills},
url = {https://claudskills.com/skills/bio-crispr-screens-mageck-analysis--skills-mageck-analysis/}
}
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Claude™ is a trademark of Anthropic PBC. ClaudSkills (also referred to as Claude Skills or Claude Code Skills Catalog) is an independent community-curated registry of SKILL.md files, not affiliated with, endorsed by, or sponsored by Anthropic.
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