Category:Science & Research · Sub-category: research-methods · Last updated:
Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.
About this skill (catalog notes)
bio-experimental-design-power-analysis includes pricing or quota commentary; at least one code block. At roughly 1,999 words the SKILL.md is on the longer end of the catalog distribution.
How bio-experimental-design-power-analysis fits the catalog
bio-experimental-design-power-analysis sits in the Science & Research category under the research-methods sub-topic in the ClaudSkills catalog. There are 10 related skills indexed alongside it; comparing a few before installing usually reveals which fits your workflow best.
These notes are auto-generated from features detected in the SKILL.md file and from this catalog's structure — they aren't part of the source repository.
What this skill does
bio-experimental-design-power-analysis is a community-contributed Claude Code skill in the research-methods sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-experimental-design-power-analysis--skills-power-analysis/ and loads when your prompt matches the skill's trigger.
When to invoke it: Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.
Who uses this skill
The bio-experimental-design-power-analysis Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 93,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).
Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-experimental-design-power-analysis--skills-power-analysis/. Claude Code auto-discovers it on next session.
Skills live at ~/.claude/skills/bio-experimental-design-power-analysis--skills-power-analysis/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-experimental-design-power-analysis--skills-power-analysis\SKILL.md on Windows. See the full install guide for step-by-step instructions.
Telegram
📱 Install from your phone or desktop Telegram
Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →
Pro
One-click install via the desktop app
The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.
Pro
For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.
How do I install the bio-experimental-design-power-analysis Claude Code skill?
Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/bio-experimental-design-power-analysis--skills-power-analysis/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.
What does the bio-experimental-design-power-analysis skill do?
Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.
Is this skill free to install?
Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.
When should I use the bio-experimental-design-power-analysis skill?
Use bio-experimental-design-power-analysis when your Claude Code task falls under the Science & Research category — specifically in the research methods area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use bio-experimental-design-power-analysis" or describe the task and let Claude pick). Browse related skills at /category/science/.
What is a Claude Code skill and how does the bio-experimental-design-power-analysis skill fit in?
A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. bio-experimental-design-power-analysis is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.
@misc{bio-experimental-design-power-analysis--skills-power-analysis-2026,
author = {bg-szy},
title = {bio-experimental-design-power-analysis [Claude Code skill]},
year = {2026},
publisher = {ClaudSkills},
url = {https://claudskills.com/skills/bio-experimental-design-power-analysis--skills-power-analysis/}
}
Embed this skill
Promote, attribute, or link this skill from your own README, blog post, or documentation. All three snippets are free to use — no sign-up, no API key. More distribution surfaces →
Claude™ is a trademark of Anthropic PBC. ClaudSkills (also referred to as Claude Skills or Claude Code Skills Catalog) is an independent community-curated registry of SKILL.md files, not affiliated with, endorsed by, or sponsored by Anthropic.
Install ClaudSkills — browse 70k+ skills offline, one tap from your home screen.