ClaudSkills / Science & Research / chemistry

Bio Methylation Array Preprocessing

Q: What is a Claude Code skill and how does the Bio Methylation Array Preprocessing skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Methylation Array Preprocessing is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at https://claudskills.com/learn/what-is-skill-md/.

Category: Science & Research · Sub-category: chemistry · Last updated: 2026-07-10

Turns raw Illumina Infinium methylation BeadChip IDATs (450K, EPIC, EPICv2) into a defensible beta/M matrix with sesame (openSesame/SigDF) or minfi (RGChannelSet -> MethylSet -> GenomicRatioSet). Covers Type I vs Type II probe chemistry and why raw Type II beta is compressed, the signal-to-beta math (beta = M/(M+U+100)) and M-value logit, detection-p / pOOBAH masking including the out-of-band deletion-artifact catch, dye-bias correction, and the normalization decision (noob, funnorm, quantile, SWAN, BMIQ, dasen, sesame QCDPB). Use when reading IDATs, choosing a normalization for a 450K/EPIC/EPICv2 cohort, deciding beta vs M, masking failed probes, or producing the corrected matrix before testing. For probe/sample filtering, EPICv2 replicate collapse, and sample-identity QC see array-qc-filtering; for native long-read 5mC see long-read-sequencing/nanopore-methylation (a different platform).

Security AStatic scan found no risk patternsHow grading works ›

What this skill does

Bio Methylation Array Preprocessing is a community-contributed Claude Code skill in the chemistry sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-methylation-array-preprocessing/ and loads when your prompt matches the skill's trigger.

When to invoke it: Use when reading IDATs, choosing a normalization for a 450K/EPIC/EPICv2 cohort, deciding beta vs M, masking failed probes, or producing the corrected matrix before testing. For probe/sample filtering, EPICv2 replicate collapse, and sample-identity QC see array-qc-filtering; for native long-read 5mC see long-read-sequencing/nanopore-methylation (a different platform).

Who uses this skill

The Bio Methylation Array Preprocessing Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 161,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/bio-methylation-array-preprocessing
curl -L https://claudskills.com/skills/bio-methylation-array-preprocessing/SKILL.md \
  -o ~/.claude/skills/bio-methylation-array-preprocessing/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-methylation-array-preprocessing/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/bio-methylation-array-preprocessing/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-methylation-array-preprocessing\SKILL.md on Windows. See the full install guide for step-by-step instructions.

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Bio Methylation Array Preprocessing Claude Code skill?

Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/bio-methylation-array-preprocessing/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.

What does the Bio Methylation Array Preprocessing skill do?

Is this skill free to install?

Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.

When should I use the Bio Methylation Array Preprocessing skill?

Use Bio Methylation Array Preprocessing when your Claude Code task falls under the Science & Research category — specifically in the chemistry area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Bio Methylation Array Preprocessing" or describe the task and let Claude pick). Browse related skills at /category/science/.

What is a Claude Code skill and how does the Bio Methylation Array Preprocessing skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Methylation Array Preprocessing is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Source: https://github.com/bg-szy/TOP-SKILLS/blob/f1ffbcdf7c367195be3ed029c5d1f9aa20f5902e/skills/awesome-skills/bio-methylation-array-preprocessing/SKILL.md
Author: bg-szy
Website: https://bg-szy.github.io/TOP-SKILLS/

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA

bg-szy. (2026). Bio Methylation Array Preprocessing [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/bio-methylation-array-preprocessing/

BibTeX

@misc{bio-methylation-array-preprocessing-2026,
  author    = {bg-szy},
  title     = {Bio Methylation Array Preprocessing [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/bio-methylation-array-preprocessing/}
}

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Security scan

Grade A · scanned 2026-07-26 — free static scan against the OWASP Agentic Skills Top 10.

No risk patterns were found in any of the ten OWASP-aligned categories. How grading works ›

✓ Prompt injection
✓ Data exfiltration
✓ Supply chain
✓ Reverse shell
✓ Credentials
✓ Execution
✓ Filesystem
✓ Persistence
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✓ Network

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Browse all Science & Research skills in the ClaudSkills registry, or explore these other picks from the same category:

Browse all Science & Research skills → Top 100 skills

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