ClaudSkills / Science & Research / biology-medicine

Bio Methylation Ewas Design

Q: What is a Claude Code skill and how does the Bio Methylation Ewas Design skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Methylation Ewas Design is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at https://claudskills.com/learn/what-is-skill-md/.

Category: Science & Research · Sub-category: biology-medicine · Last updated: 2026-07-11

Designs and defends an epigenome-wide association study (EWAS) on 450K/EPIC array or bisulfite methylation - the layer deciding whether a hit is credible. Covers the confounding hierarchy (cell composition covariates as the dominant confounder, batch/Sentrix chip/array position, age/sex, smoking AHRR cg05575921, ancestry/mQTL, reverse causation), chip randomization (no-rescue theorem), surrogate variable analysis sva/SmartSVA, ComBat, RUVm, over-correction, genomic inflation lambda vs GWAS genomic control, BACON bias/inflation, genome-wide significance threshold 450K/EPIC, FWER vs FDR, pwrEWAS power, meta-analysis, EWAS Catalog/Atlas, methylation risk scores. Use when designing an EWAS, choosing a covariate set, randomizing a plate layout, interpreting lambda, applying BACON, setting a threshold, powering a study, or using an MRS. For the per-site test see differential-cpg-testing; for cell fractions see cell-type-deconvolution; for causal mQTL orientation see causal-genomics/mendelian-randomization.

Security AStatic scan found no risk patternsHow grading works ›

What this skill does

Bio Methylation Ewas Design is a community-contributed Claude Code skill in the biology-medicine sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-methylation-ewas-design/ and loads when your prompt matches the skill's trigger.

When to invoke it: Use when designing an EWAS, choosing a covariate set, randomizing a plate layout, interpreting lambda, applying BACON, setting a threshold, powering a study, or using an MRS. For the per-site test see differential-cpg-testing; for cell fractions see cell-type-deconvolution; for causal mQTL orientation see causal-genomics/mendelian-randomization.

Who uses this skill

The Bio Methylation Ewas Design Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 161,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/bio-methylation-ewas-design
curl -L https://claudskills.com/skills/bio-methylation-ewas-design/SKILL.md \
  -o ~/.claude/skills/bio-methylation-ewas-design/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-methylation-ewas-design/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/bio-methylation-ewas-design/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-methylation-ewas-design\SKILL.md on Windows. See the full install guide for step-by-step instructions.

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Bio Methylation Ewas Design Claude Code skill?

Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/bio-methylation-ewas-design/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.

What does the Bio Methylation Ewas Design skill do?

Is this skill free to install?

Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.

When should I use the Bio Methylation Ewas Design skill?

Use Bio Methylation Ewas Design when your Claude Code task falls under the Science & Research category — specifically in the biology medicine area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Bio Methylation Ewas Design" or describe the task and let Claude pick). Browse related skills at /category/science/.

What is a Claude Code skill and how does the Bio Methylation Ewas Design skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Methylation Ewas Design is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Source: https://github.com/bg-szy/TOP-SKILLS/blob/HEAD/skills/awesome-skills/bio-methylation-ewas-design/SKILL.md
Author: bg-szy
Website: https://bg-szy.github.io/TOP-SKILLS/

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA

bg-szy. (2026). Bio Methylation Ewas Design [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/bio-methylation-ewas-design/

BibTeX

@misc{bio-methylation-ewas-design-2026,
  author    = {bg-szy},
  title     = {Bio Methylation Ewas Design [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/bio-methylation-ewas-design/}
}

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Badge

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Security scan

Grade A · scanned 2026-07-26 — free static scan against the OWASP Agentic Skills Top 10.

No risk patterns were found in any of the ten OWASP-aligned categories. How grading works ›

✓ Prompt injection
✓ Data exfiltration
✓ Supply chain
✓ Reverse shell
✓ Credentials
✓ Execution
✓ Filesystem
✓ Persistence
✓ Obfuscation
✓ Network

Show this grade on your repo (click to copy):

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Browse all Science & Research skills → Top 100 skills

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