Category:Science & Research · Sub-category: biology-medicine · Last updated:
Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.
About this skill (catalog notes)
bio-single-cell-splicing includes pricing or quota commentary; 7 code blocks for direct copy-paste. At roughly 3,390 words the SKILL.md is on the longer end of the catalog distribution.
bio-single-cell-splicing sits in the Science & Research category under the biology-medicine sub-topic in the ClaudSkills catalog. There are 10 related skills indexed alongside it; comparing a few before installing usually reveals which fits your workflow best.
These notes are auto-generated from features detected in the SKILL.md file and from this catalog's structure — they aren't part of the source repository.
What this skill does
bio-single-cell-splicing is a community-contributed Claude Code skill in the biology-medicine sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-single-cell-splicing--skills-single-cell-splicing/ and loads when your prompt matches the skill's trigger.
When to invoke it: Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.
Who uses this skill
The bio-single-cell-splicing Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 93,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).
Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-single-cell-splicing--skills-single-cell-splicing/. Claude Code auto-discovers it on next session.
Skills live at ~/.claude/skills/bio-single-cell-splicing--skills-single-cell-splicing/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-single-cell-splicing--skills-single-cell-splicing\SKILL.md on Windows. See the full install guide for step-by-step instructions.
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One-click install via the desktop app
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How do I install the bio-single-cell-splicing Claude Code skill?
Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/bio-single-cell-splicing--skills-single-cell-splicing/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.
What does the bio-single-cell-splicing skill do?
Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.
Is this skill free to install?
Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.
When should I use the bio-single-cell-splicing skill?
Use bio-single-cell-splicing when your Claude Code task falls under the Science & Research category — specifically in the biology medicine area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use bio-single-cell-splicing" or describe the task and let Claude pick). Browse related skills at /category/science/.
What is a Claude Code skill and how does the bio-single-cell-splicing skill fit in?
A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. bio-single-cell-splicing is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.
@misc{bio-single-cell-splicing--skills-single-cell-splicing-2026,
author = {bg-szy},
title = {bio-single-cell-splicing [Claude Code skill]},
year = {2026},
publisher = {ClaudSkills},
url = {https://claudskills.com/skills/bio-single-cell-splicing--skills-single-cell-splicing/}
}
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