ClaudSkills / Science & Research / biology-medicine

bio-cfdna-preprocessing

Q: What is a Claude Code skill and how does the bio-cfdna-preprocessing skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. bio-cfdna-preprocessing is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at https://claudskills.com/learn/what-is-skill-md/.

Category: Science & Research · Sub-category: biology-medicine · Last updated: 2026-06-13

Decides how to preprocess plasma cfDNA sequencing data so the recoverable signal survives - library-prep-aware fragment expectations (dsDNA vs ssDNA/adaptase prep), UMI/duplex consensus with fgbio (ExtractUmisFromBam, GroupReadsByUmi --strategy paired for duplex, CallMolecularConsensusReads vs CallDuplexConsensusReads, FilterConsensusReads min-reads "total s1 s2"), the align->group->consensus->RE-align ordering, and the cfDNA dedup trap where naive coordinate dedup collapses nucleosome-coincident independent molecules. Covers when single-strand consensus suffices vs when duplex is mandatory, the singleton/sensitivity tax at low input, and reading the insert-size histogram as a pre-analytical QC instrument. Use when processing plasma cfDNA reads before fragmentomics, ctDNA mutation calling, or tumor-fraction estimation.

About this skill (catalog notes)

bio-cfdna-preprocessing includes pricing or quota commentary; at least one code block. At roughly 2,517 words the SKILL.md is on the longer end of the catalog distribution.

Source: github.com/FridrichMethod/awesome-skills
Original author: FridrichMethod
Indexed lastmod: 2026-06-13
Catalog position: Science & Research · biology-medicine
Indexed related skills: 10

How bio-cfdna-preprocessing fits the catalog

bio-cfdna-preprocessing sits in the Science & Research category under the biology-medicine sub-topic in the ClaudSkills catalog. There are 10 related skills indexed alongside it; comparing a few before installing usually reveals which fits your workflow best.

These notes are auto-generated from features detected in the SKILL.md file and from this catalog's structure — they aren't part of the source repository.

What this skill does

bio-cfdna-preprocessing is a community-contributed Claude Code skill in the biology-medicine sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/cfdna-preprocessing/ and loads when your prompt matches the skill's trigger.

When to invoke it: Use when processing plasma cfDNA reads before fragmentomics, ctDNA mutation calling, or tumor-fraction estimation.

Who uses this skill

The bio-cfdna-preprocessing Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 116,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/cfdna-preprocessing
curl -L https://claudskills.com/skills/cfdna-preprocessing/SKILL.md \
  -o ~/.claude/skills/cfdna-preprocessing/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/cfdna-preprocessing/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/cfdna-preprocessing/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\cfdna-preprocessing\SKILL.md on Windows. See the full install guide for step-by-step instructions.

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

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See pricing → Download desktop app

Frequently asked questions

How do I install the bio-cfdna-preprocessing Claude Code skill?

Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/cfdna-preprocessing/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.

What does the bio-cfdna-preprocessing skill do?

Is this skill free to install?

Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.

When should I use the bio-cfdna-preprocessing skill?

Use bio-cfdna-preprocessing when your Claude Code task falls under the Science & Research category — specifically in the biology medicine area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use bio-cfdna-preprocessing" or describe the task and let Claude pick). Browse related skills at /category/science/.

What is a Claude Code skill and how does the bio-cfdna-preprocessing skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. bio-cfdna-preprocessing is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Source: https://github.com/FridrichMethod/awesome-skills/blob/ff13a5618b8900638dd7cfff0fb8f1cad08815e9/skills/cfdna-preprocessing/SKILL.md
Author: FridrichMethod
Website: https://github.com/FridrichMethod/awesome-skills

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA

FridrichMethod. (2026). bio-cfdna-preprocessing [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/cfdna-preprocessing/

BibTeX

@misc{cfdna-preprocessing-2026,
  author    = {FridrichMethod},
  title     = {bio-cfdna-preprocessing [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/cfdna-preprocessing/}
}

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