ClaudSkills / Science & Research / biology-medicine

Chai1

Q: What is a Claude Code skill and how does the Chai1 skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Chai1 is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at https://claudskills.com/learn/what-is-skill-md/.

Category: Science & Research · Sub-category: biology-medicine · Last updated: 2026-07-17

lang:python

Structure prediction for protein, nucleic-acid, and small-molecule complexes with the Chai-1 foundation model (Chai Discovery 2024, github.com/chaidiscovery/chai-lab). Reach for this skill to predict an antibody-antigen or protein-ligand complex from a single FASTA, to re-fold designed binders as an AlphaFold-multimer alternative, or to drive co-folding from Python for batched campaigns on a GPU.

Security AStatic scan found no risk patternsHow grading works ›

From the source SKILL.md

Chai-1 is an all-atom diffusion co-folder in the same family as Boltz-2 and AlphaFold3: a multi-entity FASTA in, mmCIF plus pTM/ipTM/pLDDT out, with protein, RNA, DNA, and SMILES-ligand chains all first-class. It and boltz cover the same surface; running both and keeping designs that pass either is a common consensus filter, and Chai's Python entry point makes it the easier of the two to embed in a loop. Code and weights are Apache-2.0 — commercial use including drug discovery is explicitly permitted (github.com/chaidiscovery/chai-lab).

What this skill does

Chai1 is a community-contributed Claude Code skill in the biology-medicine sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/chai1/ and loads when your prompt matches the skill's trigger.

Who uses this skill

The Chai1 Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 158,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/chai1
curl -L https://claudskills.com/skills/chai1/SKILL.md \
  -o ~/.claude/skills/chai1/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/chai1/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/chai1/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\chai1\SKILL.md on Windows. See the full install guide for step-by-step instructions.

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Chai1 Claude Code skill?

Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/chai1/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.

What does the Chai1 skill do?

Is this skill free to install?

Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.

When should I use the Chai1 skill?

Use Chai1 when your Claude Code task falls under the Science & Research category — specifically in the biology medicine area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Chai1" or describe the task and let Claude pick). Browse related skills at /category/science/.

What is a Claude Code skill and how does the Chai1 skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Chai1 is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Source: https://github.com/xuzhougeng/wisp-science/blob/HEAD/skills/chai1/SKILL.md
License: Apache-2.0
Author: xuzhougeng
Website: https://wispscience.com/

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA

xuzhougeng. (2026). Chai1 [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/chai1/

BibTeX

@misc{chai1-2026,
  author    = {xuzhougeng},
  title     = {Chai1 [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/chai1/}
}

Embed this skill

Promote, attribute, or link this skill from your own README, blog post, or documentation. All three snippets are free to use — no sign-up, no API key. More distribution surfaces →

Badge

[![ClaudSkills](https://claudskills.com/badge/chai1.svg)](https://claudskills.com/skills/chai1/?utm_source=badge&utm_medium=readme&utm_campaign=skill_badge)

Security scan

Grade A · scanned 2026-07-23 — free static scan against the OWASP Agentic Skills Top 10.

No risk patterns were found in any of the ten OWASP-aligned categories. How grading works ›

✓ Prompt injection
✓ Data exfiltration
✓ Supply chain
✓ Reverse shell
✓ Credentials
✓ Execution
✓ Filesystem
✓ Persistence
✓ Obfuscation
✓ Network

Show this grade on your repo (click to copy):

[![Security: A](https://img.shields.io/badge/Security-A-2e7d32)](https://claudskills.com/skills/chai1/#security)

More Science & Research skills

Browse all Science & Research skills in the ClaudSkills registry, or explore these other picks from the same category:

Browse all Science & Research skills → Top 100 skills

Part of ClaudSkills — the open registry for Claude Skills & Claude Code Skills. · What's New · Install guide · About · llms.txt

Part of Acreator Store — Adam Lankamer's AI tools: PerfectStudio · Ucaption · UTagger · AutoXPoster · TestYourSkills · AutomationFlows · Au Naturel · Telegram @acreatorstore