ClaudSkills / Science & Research / biology-medicine

Esmfold2

Q: What is a Claude Code skill and how does the Esmfold2 skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Esmfold2 is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at https://claudskills.com/learn/what-is-skill-md/.

Category: Science & Research · Sub-category: biology-medicine · Last updated: 2026-07-17

Biohub ESMFold2 / ESMFold2-Fast all-atom co-folding (Candido et al. 2026, github.com/Biohub/esm). Single-sequence and MSA modes; protein, DNA, RNA, ligand (CCD/SMILES), modified residues. FoldBench Ab-Ag 50-55%, PPI 70-77% DockQ-pass. Also covers the ESMC-{300M,600M,6B} protein language models from the same release: masked-LM logits, hidden states, mutation scoring, contact prediction, and the SAE interpretability head. MIT-licensed weights on HuggingFace org `biohub`. Use this skill when: (1) Predicting complex structures with single-sequence input, (2) Validating designed binders with ESMFold2-Fast, (3) Running ESMFold2 with MSA input, (4) Getting ESMC embeddings or per-residue mutation scores, (5) Choosing kernel backend and sampling-step settings for paper-faithful throughput.

Security AStatic scan found no risk patternsHow grading works ›

About this skill (catalog notes)

Esmfold2 includes a dedicated installation section; worked examples; 5 code blocks for direct copy-paste. The SKILL.md runs to about 1,057 words, in the catalog's typical mid-range.

Source: wispscience.com
License: Apache-2.0
Original author: xuzhougeng
Indexed lastmod: 2026-07-17
Catalog position: Science & Research · biology-medicine
Indexed related skills: 10

How Esmfold2 fits the catalog

Esmfold2 sits in the Science & Research category under the biology-medicine sub-topic in the ClaudSkills catalog. There are 10 related skills indexed alongside it; comparing a few before installing usually reveals which fits your workflow best.

These notes are auto-generated from features detected in the SKILL.md file and from this catalog's structure — they aren't part of the source repository.

From the source SKILL.md

All-atom diffusion co-folding from the Biohub ESM release (2026). ESMFold2 = 48 pair layers with MSA support; ESMFold2-Fast = 24 layers, single-sequence only, ~1.7x faster.

What this skill does

Esmfold2 is a community-contributed Claude Code skill in the biology-medicine sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/esmfold2/ and loads when your prompt matches the skill's trigger.

Who uses this skill

The Esmfold2 Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 161,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/esmfold2
curl -L https://claudskills.com/skills/esmfold2/SKILL.md \
  -o ~/.claude/skills/esmfold2/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/esmfold2/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/esmfold2/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\esmfold2\SKILL.md on Windows. See the full install guide for step-by-step instructions.

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Esmfold2 Claude Code skill?

Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/esmfold2/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.

What does the Esmfold2 skill do?

Is this skill free to install?

Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.

When should I use the Esmfold2 skill?

Use Esmfold2 when your Claude Code task falls under the Science & Research category — specifically in the biology medicine area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Esmfold2" or describe the task and let Claude pick). Browse related skills at /category/science/.

What is a Claude Code skill and how does the Esmfold2 skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Esmfold2 is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Source: https://github.com/xuzhougeng/wisp-science/blob/HEAD/skills/esmfold2/SKILL.md
License: Apache-2.0
Author: xuzhougeng
Website: https://wispscience.com/

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA

xuzhougeng. (2026). Esmfold2 [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/esmfold2/

BibTeX

@misc{esmfold2-2026,
  author    = {xuzhougeng},
  title     = {Esmfold2 [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/esmfold2/}
}

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Badge

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Security scan

Grade A · scanned 2026-07-26 — free static scan against the OWASP Agentic Skills Top 10.

The scan flagged 2 of 10 categories (execution, supply-chain), including lower-severity patterns. Patterns shown inside code fences are weighted as examples rather than instructions — read the grading methodology for what this does and does not guarantee.

✓ Prompt injection
✓ Data exfiltration
⚠ Supply chain
✓ Reverse shell
✓ Credentials
⚠ Execution
✓ Filesystem
✓ Persistence
✓ Obfuscation
✓ Network

Show this grade on your repo (click to copy):

[![Security: A](https://img.shields.io/badge/Security-A-2e7d32)](https://claudskills.com/skills/esmfold2/#security)

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