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ClaudSkills / Science & Research / physics

Primer Design

Category: Science & Research  ·  Sub-category: physics  ·  Last updated:
type:audit
Designs and audits PCR and RT-qPCR primers with Primer3, explicit thermodynamic conditions, reference-based off-target amplification searches, and traceable sequence coordinates. Use for designing primer pairs, checking existing primers, exon-junction or isoform-specific assays, variant masking, cloning tails, multiplex compatibility, and interpreting Primer-BLAST results. Includes bounded local in-silico PCR and BLAST screening; distinguishes computational candidates from experimentally validated assays.
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From the source SKILL.md

Produce candidate oligos in 5-prime-to-3-prime orientation, with the exact template, chemistry, intended products, and search scope behind each conclusion. Calculate sequence-dependent quantities with the supplied tools. A familiar gene name, good Primer3 penalty, or a single BLAST alignment cannot establish primer specificity.

What this skill does

Primer Design is a community-contributed Claude Code skill in the physics sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/primer-design/ and loads when your prompt matches the skill's trigger.

Who uses this skill

The Primer Design Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 213,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/primer-design
curl -L https://claudskills.com/skills/primer-design/SKILL.md \
  -o ~/.claude/skills/primer-design/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/primer-design/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/primer-design/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\primer-design\SKILL.md on Windows. See the full install guide for step-by-step instructions.

Telegram

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Primer Design Claude Code skill?
Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/primer-design/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.
What does the Primer Design skill do?
Designs and audits PCR and RT-qPCR primers with Primer3, explicit thermodynamic conditions, reference-based off-target amplification searches, and traceable sequence coordinates. Use for designing primer pairs, checking existing primers, exon-junction or isoform-specific assays, variant masking, cloning tails, multiplex compatibility, and interpreting Primer-BLAST results. Includes bounded local in-silico PCR and BLAST screening; distinguishes computational candidates from experimentally validated assays.
Is this skill free to install?
Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.
When should I use the Primer Design skill?
Use Primer Design when your Claude Code task falls under the Science & Research category — specifically in the physics area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Primer Design" or describe the task and let Claude pick). Browse related skills at /category/science/.
What is a Claude Code skill and how does the Primer Design skill fit in?
A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Primer Design is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA
LeoYeAI. (2026). Primer Design [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/primer-design/
BibTeX
@misc{primer-design-2026,
  author    = {LeoYeAI},
  title     = {Primer Design [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/primer-design/}
}

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Grade A · scanned 2026-11-01 — free static scan against the OWASP Agentic Skills Top 10.

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More Science & Research skills

Browse all Science & Research skills in the ClaudSkills registry, or explore these other picks from the same category:

Browse all Science & Research skills → Top 100 skills
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