Snpeff Variant Annotation

Quality score: 70/100 · Category: Content · Sub-category: content-misc

lang:pythontype:integration

Annotate and filter VCF variants with SnpEff and SnpSift. SnpEff predicts functional effects (HIGH/MODERATE/LOW/MODIFIER), genes, transcripts, AA changes, HGVS; SnpSift filters and adds ClinVar/dbSNP. Java CLI with Python subprocess integration. Use ANNOVAR for multi-database annotation; Ensembl VEP for REST API; SnpEff for fast CLI with pre-built genomes.

What this skill does

Snpeff Variant Annotation is a production-ready Claude Code skill (quality score 70/100) in the content-misc sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/snpeff-variant-annotation/ and loads when your prompt matches the skill's trigger.

Who uses this skill

The Snpeff Variant Annotation skill is built for content creators, marketers, copywriters, SEO professionals, and editorial teams. It is part of the open ClaudSkills registry, a community-curated catalog of 15,000+ capabilities you can install for Claude Code — the Claude CLI agent.

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/snpeff-variant-annotation
curl -L https://claudskills.com/skills/snpeff-variant-annotation/SKILL.md \
  -o ~/.claude/skills/snpeff-variant-annotation/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/snpeff-variant-annotation/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/snpeff-variant-annotation/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\snpeff-variant-annotation\SKILL.md on Windows. See the full install guide for step-by-step instructions.

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.