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Tooluniverse Primer Design

Category: Science & Research  ·  Sub-category: physics  ·  Last updated:
PCR / qPCR primer and oligo design — design forward/reverse primers for a target region (SantaLucia nearest-neighbor thermodynamics), compute melting temperature (Tm) and annealing temperature (Ta), check GC content, and screen an oligo for hairpins and primer-dimers. Use when you need primers for a sequence, want to QC an existing primer pair, or need the Tm of an oligo. Covers the primer-design rules (Tm matching, GC clamp, 3'-end, length) and the tools' constraint quirks.
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From the source SKILL.md

Design primers for a target DNA region, get their Tm/Ta, and QC them for the secondary-structure problems that make a PCR fail.

What this skill does

Tooluniverse Primer Design is a community-contributed Claude Code skill in the physics sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/tooluniverse-primer-design/ and loads when your prompt matches the skill's trigger.

When to invoke it: Use when you need primers for a sequence, want to QC an existing primer pair, or need the Tm of an oligo. Covers the primer-design rules (Tm matching, GC clamp, 3'-end, length) and the tools' constraint quirks.

Who uses this skill

The Tooluniverse Primer Design Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 161,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/tooluniverse-primer-design
curl -L https://claudskills.com/skills/tooluniverse-primer-design/SKILL.md \
  -o ~/.claude/skills/tooluniverse-primer-design/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/tooluniverse-primer-design/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/tooluniverse-primer-design/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\tooluniverse-primer-design\SKILL.md on Windows. See the full install guide for step-by-step instructions.

Telegram

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Tooluniverse Primer Design Claude Code skill?
Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/tooluniverse-primer-design/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.
What does the Tooluniverse Primer Design skill do?
PCR / qPCR primer and oligo design — design forward/reverse primers for a target region (SantaLucia nearest-neighbor thermodynamics), compute melting temperature (Tm) and annealing temperature (Ta), check GC content, and screen an oligo for hairpins and primer-dimers. Use when you need primers for a sequence, want to QC an existing primer pair, or need the Tm of an oligo. Covers the primer-design rules (Tm matching, GC clamp, 3'-end, length) and the tools' constraint quirks.
Is this skill free to install?
Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.
When should I use the Tooluniverse Primer Design skill?
Use Tooluniverse Primer Design when your Claude Code task falls under the Science & Research category — specifically in the physics area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Tooluniverse Primer Design" or describe the task and let Claude pick). Browse related skills at /category/science/.
What is a Claude Code skill and how does the Tooluniverse Primer Design skill fit in?
A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Tooluniverse Primer Design is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA
mims-harvard. (2026). Tooluniverse Primer Design [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/tooluniverse-primer-design/
BibTeX
@misc{tooluniverse-primer-design-2026,
  author    = {mims-harvard},
  title     = {Tooluniverse Primer Design [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/tooluniverse-primer-design/}
}

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Grade A · scanned 2026-07-26 — free static scan against the OWASP Agentic Skills Top 10.

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