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ClaudSkills / Science & Research / math-stats

Trial Design Optimizer

Category: Science & Research  ·  Sub-category: math-stats  ·  Last updated:
Generate optimized clinical trial designs given a therapeutic hypothesis, target population, and development stage. Incorporates adaptive designs, modern estimand frameworks, and synthetic control arm feasibility assessment. Reference when evaluating whether a company's trial design maximizes probability of success while minimizing cost and timeline, or when designing de novo studies for platform companies.
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About this skill (catalog notes)

Trial Design Optimizer includes worked examples; pricing or quota commentary; at least one code block. The SKILL.md runs to about 1,394 words, in the catalog's typical mid-range.

Source
skill-library-prod.web.app
License
MIT
Original author
npbuilds
Indexed lastmod
Catalog position
Science & Research · math-stats
Indexed related skills
10

How Trial Design Optimizer fits the catalog

Trial Design Optimizer sits in the Science & Research category under the math-stats sub-topic in the ClaudSkills catalog. There are 10 related skills indexed alongside it; comparing a few before installing usually reveals which fits your workflow best.

These notes are auto-generated from features detected in the SKILL.md file and from this catalog's structure — they aren't part of the source repository.

From the source SKILL.md

Trial design is where clinical development budgets are won or lost. A well-designed Phase 2 with an adaptive enrichment strategy can deliver the same signal as a conventional Phase 3 at one-third the cost. A poorly designed pivotal trial burns $150-300M and 3-4 years before delivering an uninterpretable result. The physician-scientist's edge in venture is recognizing design flaws that financial analysts cannot see: an inadequate run-in period, a composite endpoint that dilutes signal, a control arm that will be obsolete by readout.

What this skill does

Trial Design Optimizer is a community-contributed Claude Code skill in the math-stats sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/trial-design-optimizer/ and loads when your prompt matches the skill's trigger.

Who uses this skill

The Trial Design Optimizer Claude Code skill is built for researchers, data scientists, academics, and analysts working with complex data and scientific literature. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 168,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/trial-design-optimizer
curl -L https://claudskills.com/skills/trial-design-optimizer/SKILL.md \
  -o ~/.claude/skills/trial-design-optimizer/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/trial-design-optimizer/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/trial-design-optimizer/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\trial-design-optimizer\SKILL.md on Windows. See the full install guide for step-by-step instructions.

Telegram

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Trial Design Optimizer Claude Code skill?
Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/trial-design-optimizer/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.
What does the Trial Design Optimizer skill do?
Generate optimized clinical trial designs given a therapeutic hypothesis, target population, and development stage. Incorporates adaptive designs, modern estimand frameworks, and synthetic control arm feasibility assessment. Reference when evaluating whether a company's trial design maximizes probability of success while minimizing cost and timeline, or when designing de novo studies for platform companies.
Is this skill free to install?
Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.
When should I use the Trial Design Optimizer skill?
Use Trial Design Optimizer when your Claude Code task falls under the Science & Research category — specifically in the math stats area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Trial Design Optimizer" or describe the task and let Claude pick). Browse related skills at /category/science/.
What is a Claude Code skill and how does the Trial Design Optimizer skill fit in?
A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Trial Design Optimizer is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the Science & Research category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA
npbuilds. (2026). Trial Design Optimizer [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/trial-design-optimizer/
BibTeX
@misc{trial-design-optimizer-2026,
  author    = {npbuilds},
  title     = {Trial Design Optimizer [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/trial-design-optimizer/}
}

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Security scan

Grade A · scanned 2026-07-31 — free static scan against the OWASP Agentic Skills Top 10.

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More Science & Research skills

Browse all Science & Research skills in the ClaudSkills registry, or explore these other picks from the same category:

Browse all Science & Research skills → Top 100 skills
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