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Bio Causal Genomics Effector Gene Prioritization

Category: General  ·  Sub-category: general-misc  ·  Last updated:
Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

About this skill (catalog notes)

Bio Causal Genomics Effector Gene Prioritization includes pricing or quota commentary; 6 code blocks for direct copy-paste. At roughly 5,562 words the SKILL.md is on the longer end of the catalog distribution.

Source
bg-szy.github.io/TOP-SKILLS
Original author
bg-szy
Indexed lastmod
Catalog position
General · general-misc
Indexed related skills
10

How Bio Causal Genomics Effector Gene Prioritization fits the catalog

Bio Causal Genomics Effector Gene Prioritization sits in the General category under the general-misc sub-topic in the ClaudSkills catalog. There are 10 related skills indexed alongside it; comparing a few before installing usually reveals which fits your workflow best.

These notes are auto-generated from features detected in the SKILL.md file and from this catalog's structure — they aren't part of the source repository.

What this skill does

Bio Causal Genomics Effector Gene Prioritization is a community-contributed Claude Code skill in the general-misc sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-causal-genomics-effector-gene-prioritization/ and loads when your prompt matches the skill's trigger.

When to invoke it: Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

Who uses this skill

The Bio Causal Genomics Effector Gene Prioritization Claude Code skill is built for Claude Code users and developers across all disciplines looking for general-purpose AI assistance. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 119,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/bio-causal-genomics-effector-gene-prioritization
curl -L https://claudskills.com/skills/bio-causal-genomics-effector-gene-prioritization/SKILL.md \
  -o ~/.claude/skills/bio-causal-genomics-effector-gene-prioritization/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-causal-genomics-effector-gene-prioritization/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/bio-causal-genomics-effector-gene-prioritization/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-causal-genomics-effector-gene-prioritization\SKILL.md on Windows. See the full install guide for step-by-step instructions.

Telegram

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

Frequently asked questions

How do I install the Bio Causal Genomics Effector Gene Prioritization Claude Code skill?
Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/bio-causal-genomics-effector-gene-prioritization/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.
What does the Bio Causal Genomics Effector Gene Prioritization skill do?
Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.
Is this skill free to install?
Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.
When should I use the Bio Causal Genomics Effector Gene Prioritization skill?
Use Bio Causal Genomics Effector Gene Prioritization when your Claude Code task falls under the General category — specifically in the general misc area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Bio Causal Genomics Effector Gene Prioritization" or describe the task and let Claude pick). Browse related skills at /category/general/.
What is a Claude Code skill and how does the Bio Causal Genomics Effector Gene Prioritization skill fit in?
A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Causal Genomics Effector Gene Prioritization is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the General category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA
bg-szy. (2026). Bio Causal Genomics Effector Gene Prioritization [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/bio-causal-genomics-effector-gene-prioritization/
BibTeX
@misc{bio-causal-genomics-effector-gene-prioritization-2026,
  author    = {bg-szy},
  title     = {Bio Causal Genomics Effector Gene Prioritization [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/bio-causal-genomics-effector-gene-prioritization/}
}

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