ClaudSkills / General / orchestration-frameworks

Bio Clinical Databases Acmg Classification

Q: What is a Claude Code skill and how does the Bio Clinical Databases Acmg Classification skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Clinical Databases Acmg Classification is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the General category. Learn more at https://claudskills.com/learn/what-is-skill-md/.

Category: General · Sub-category: orchestration-frameworks · Last updated: 2026-06-02

Applies ACMG/AMP 2015 framework with ClinGen SVI specifications, Tavtigian 2018/2020 Bayesian point system, Abou Tayoun 2018 PVS1 decision tree, Pejaver 2022 calibrated PP3/BP4 thresholds for REVEL/BayesDel/AlphaMissense, Brnich 2020 PS3/BS3 OddsPath, Walker 2023 SpliceAI splicing framework, and AMP/ASCO/CAP 2017 tumor tiers. Use when classifying germline variants P / LP / VUS / LB / B, applying VCEP-specific CSpec rules, computing Whiffin BS1, or assigning cancer Tier I-IV per Li 2017.

What this skill does

Bio Clinical Databases Acmg Classification is a community-contributed Claude Code skill in the orchestration-frameworks sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/bio-clinical-databases-acmg-classification/ and loads when your prompt matches the skill's trigger.

When to invoke it: Use when classifying germline variants P / LP / VUS / LB / B, applying VCEP-specific CSpec rules, computing Whiffin BS1, or assigning cancer Tier I-IV per Li 2017.

Who uses this skill

The Bio Clinical Databases Acmg Classification Claude Code skill is built for Claude Code users and developers across all disciplines looking for general-purpose AI assistance. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 85,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/bio-clinical-databases-acmg-classification
curl -L https://claudskills.com/skills/bio-clinical-databases-acmg-classification/SKILL.md \
  -o ~/.claude/skills/bio-clinical-databases-acmg-classification/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/bio-clinical-databases-acmg-classification/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/bio-clinical-databases-acmg-classification/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\bio-clinical-databases-acmg-classification\SKILL.md on Windows. See the full install guide for step-by-step instructions.

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Bio Clinical Databases Acmg Classification Claude Code skill?

Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/bio-clinical-databases-acmg-classification/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.

What does the Bio Clinical Databases Acmg Classification skill do?

Is this skill free to install?

Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.

When should I use the Bio Clinical Databases Acmg Classification skill?

Use Bio Clinical Databases Acmg Classification when your Claude Code task falls under the General category — specifically in the orchestration frameworks area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Bio Clinical Databases Acmg Classification" or describe the task and let Claude pick). Browse related skills at /category/general/.

What is a Claude Code skill and how does the Bio Clinical Databases Acmg Classification skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Bio Clinical Databases Acmg Classification is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the General category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Source: https://github.com/bg-szy/TOP-SKILLS/blob/HEAD/skills/awesome-skills/bio-clinical-databases-acmg-classification/SKILL.md
Author: bg-szy
Website: https://bg-szy.github.io/TOP-SKILLS/

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA

bg-szy. (2026). Bio Clinical Databases Acmg Classification [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/bio-clinical-databases-acmg-classification/

BibTeX

@misc{bio-clinical-databases-acmg-classification-2026,
  author    = {bg-szy},
  title     = {Bio Clinical Databases Acmg Classification [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/bio-clinical-databases-acmg-classification/}
}

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