Cofold Qc

Q: What is a Claude Code skill and how does the Cofold Qc skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Cofold Qc is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the General category. Learn more at https://claudskills.com/learn/what-is-skill-md/.

Category: General · Sub-category: general-misc · Last updated: 2026-06-30

Deterministic physical-validity gate for co-folding model output (protein + ligand predicted in one frame, e.g. Boltz-2, AlphaFold-3, Chai-1) with karyon. Use AFTER predicting a protein-ligand complex and BEFORE trusting the pose — it answers "is this pose physically valid?" with a pass/fail verdict and legible per-reason explanations (ligand-protein clash, volume overlap, out-of-pocket placement, plus the ligand's own bond/angle/ring/strain geometry). No GPU required.

Security AStatic scan found no risk patternsHow grading works ›

From the source SKILL.md

A deterministic, legible physical-validity gate for co-folding poses. Co-folding models (Boltz-2, AlphaFold-3, Chai-1) predict a protein and a ligand together in one coordinate frame — powerful but not self-checking: a pose can score well on confidence yet be physically invalid, the ligand clashing into the protein, burying into its volume, or floating outside any pocket. This skill is the programmatic version of the "inspect it in PyMOL for obvious clashes" sanity check: a design-rule check (DRC) that returns a named reason for every violation, not just a score.

What this skill does

Cofold Qc is a community-contributed Claude Code skill in the general-misc sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/cofold-qc/ and loads when your prompt matches the skill's trigger.

Who uses this skill

The Cofold Qc Claude Code skill is built for Claude Code users and developers across all disciplines looking for general-purpose AI assistance. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 196,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/cofold-qc
curl -L https://claudskills.com/skills/cofold-qc/SKILL.md \
  -o ~/.claude/skills/cofold-qc/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/cofold-qc/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/cofold-qc/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\cofold-qc\SKILL.md on Windows. See the full install guide for step-by-step instructions.

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Cofold Qc Claude Code skill?

Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/cofold-qc/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.

What does the Cofold Qc skill do?

Is this skill free to install?

Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.

When should I use the Cofold Qc skill?

Use Cofold Qc when your Claude Code task falls under the General category — specifically in the general misc area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Cofold Qc" or describe the task and let Claude pick). Browse related skills at /category/general/.

What is a Claude Code skill and how does the Cofold Qc skill fit in?

A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Cofold Qc is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the General category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Source: https://github.com/Curtisflo/karyon/blob/HEAD/skills/cofold-qc/SKILL.md
Author: Curtisflo
Website: https://pypi.org/project/karyon/

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA

Curtisflo. (2026). Cofold Qc [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/cofold-qc/

BibTeX

@misc{cofold-qc-2026,
  author    = {Curtisflo},
  title     = {Cofold Qc [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/cofold-qc/}
}

Embed this skill

Promote, attribute, or link this skill from your own README, blog post, or documentation. All three snippets are free to use — no sign-up, no API key. More distribution surfaces →

Badge

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Security scan

Grade A · scanned 2026-09-28 — free static scan against the OWASP Agentic Skills Top 10.

No risk patterns were found in any of the ten OWASP-aligned categories. How grading works ›

✓ Prompt injection
✓ Data exfiltration
✓ Supply chain
✓ Reverse shell
✓ Credentials
✓ Execution
✓ Filesystem
✓ Persistence
✓ Obfuscation
✓ Network

Show this grade on your repo (click to copy):

[![Security: A](https://img.shields.io/badge/Security-A-2e7d32)](https://claudskills.com/skills/cofold-qc/#security)

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Part of ClaudSkills — the open registry for Claude Skills & Claude Code Skills. · What's New · Install guide · About · llms.txt

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