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Log Fold Change Shrinkage Estimation

Category: General  ·  Sub-category: general-misc  ·  Last updated:
Use when after running DESeq() and extracting base results with results(), apply shrinkage when you have differential expression estimates and want to reduce the variance of log fold change estimates while preserving signal.
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About this skill (catalog notes)

Log Fold Change Shrinkage Estimation includes explicit scope boundaries (an explicit 'when not to use' or 'out of scope' section); worked examples; at least one code block. The SKILL.md runs to about 828 words, in the catalog's typical mid-range.

Source
holobiomicslab.cnrs.fr
License
Apache-2.0
Original author
HolobiomicsLab
Indexed lastmod
Catalog position
General · general-misc
Indexed related skills
10

How Log Fold Change Shrinkage Estimation fits the catalog

Log Fold Change Shrinkage Estimation sits in the General category under the general-misc sub-topic in the ClaudSkills catalog. There are 10 related skills indexed alongside it; comparing a few before installing usually reveals which fits your workflow best.

These notes are auto-generated from features detected in the SKILL.md file and from this catalog's structure — they aren't part of the source repository.

What this skill does

Log Fold Change Shrinkage Estimation is a community-contributed Claude Code skill in the general-misc sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/log-fold-change-shrinkage-estimation/ and loads when your prompt matches the skill's trigger.

When to invoke it: Use when after running DESeq() and extracting base results with results(), apply shrinkage when you have differential expression estimates and want to reduce the variance of log fold change estimates while preserving signal.

Who uses this skill

The Log Fold Change Shrinkage Estimation Claude Code skill is built for Claude Code users and developers across all disciplines looking for general-purpose AI assistance. It's part of ClaudSkills (also referred to as Claude Skills or Claude Code Skills) — the open community-curated registry of 146,000+ SKILL.md files for Anthropic's Claude Code agent and the wider Claude ecosystem (Claude API, Claude Agent SDK).

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/log-fold-change-shrinkage-estimation
curl -L https://claudskills.com/skills/log-fold-change-shrinkage-estimation/SKILL.md \
  -o ~/.claude/skills/log-fold-change-shrinkage-estimation/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/log-fold-change-shrinkage-estimation/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/log-fold-change-shrinkage-estimation/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\log-fold-change-shrinkage-estimation\SKILL.md on Windows. See the full install guide for step-by-step instructions.

Telegram

📱 Install from your phone or desktop Telegram

Open @claudskills_bot on Telegram, tap Open Desktop App, and the desktop app installs this skill for you. Or share the bot link with a colleague — they get the same one-tap install. Learn more →

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

Pro

For the full experience including quality scoring and one-click install features for each skill — upgrade to Pro.

See pricing → Download desktop app

Frequently asked questions

How do I install the Log Fold Change Shrinkage Estimation Claude Code skill?
Install via the ClaudSkills desktop app (one click) or copy SKILL.md from the source repository to ~/.claude/skills/log-fold-change-shrinkage-estimation/SKILL.md and restart Claude Code. Both flows are detailed at claudskills.com/install/.
What does the Log Fold Change Shrinkage Estimation skill do?
Use when after running DESeq() and extracting base results with results(), apply shrinkage when you have differential expression estimates and want to reduce the variance of log fold change estimates while preserving signal.
Is this skill free to install?
Yes. ClaudSkills is an open registry — every skill keeps its source repository's license, and manual install via copy is free. ClaudSkills Pro ($9/mo, $79/yr, or $149 one-time) adds one-click install via the desktop app and a multi-signal Quality Score.
When should I use the Log Fold Change Shrinkage Estimation skill?
Use Log Fold Change Shrinkage Estimation when your Claude Code task falls under the General category — specifically in the general misc area. Claude Code auto-discovers installed skills and invokes the right one based on the task description, so you can also ask Claude directly (e.g. "use Log Fold Change Shrinkage Estimation" or describe the task and let Claude pick). Browse related skills at /category/general/.
What is a Claude Code skill and how does the Log Fold Change Shrinkage Estimation skill fit in?
A Claude Code skill is a SKILL.md file that lives under ~/.claude/skills/<name>/ and tells the Claude Code CLI agent how to perform a specific task (instructions, prompts, allowed tools). Skills are auto-discovered at session start. Log Fold Change Shrinkage Estimation is one of 67,000+ skills indexed in the open ClaudSkills catalog, classified under the General category. Learn more at /learn/what-is-a-claude-skill/.

Attribution & license

Cite this skill

If you reference this skill in a blog post, paper, or documentation, you can cite it as:

APA
HolobiomicsLab. (2026). Log Fold Change Shrinkage Estimation [Claude Code skill]. ClaudSkills. https://claudskills.com/skills/log-fold-change-shrinkage-estimation/
BibTeX
@misc{log-fold-change-shrinkage-estimation-2026,
  author    = {HolobiomicsLab},
  title     = {Log Fold Change Shrinkage Estimation [Claude Code skill]},
  year      = {2026},
  publisher = {ClaudSkills},
  url       = {https://claudskills.com/skills/log-fold-change-shrinkage-estimation/}
}

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Security scan

Grade A · scanned 2026-07-06 — free static scan against the OWASP Agentic Skills Top 10.

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