Vcf Variant Filtering

Quality score: 70/100 · Category: General · Sub-category: general-misc

Guide to quality filtering raw VCF files before computing summary stats (Ts/Tv ratio, variant counts, AF distributions). Covers detecting raw VCFs via FILTER column and QUAL inspection, QUAL-based filtering with bcftools, Ts/Tv interpretation, and when NOT to filter. Read before any variant-level QC task. See bcftools-variant-manipulation for advanced filters, gatk-variant-calling for caller config, samtools-bam-processing for upstream alignment QC.

What this skill does

Vcf Variant Filtering is a production-ready Claude Code skill (quality score 70/100) in the general-misc sub-category. It ships as a SKILL.md file that Claude Code auto-discovers under ~/.claude/skills/vcf-variant-filtering/ and loads when your prompt matches the skill's trigger.

Who uses this skill

The Vcf Variant Filtering skill is built for Claude Code users and developers across all disciplines looking for general-purpose AI assistance. It is part of the open ClaudSkills registry, a community-curated catalog of 15,000+ capabilities you can install for Claude Code — the Claude CLI agent.

How to install

Free

Manual install (2 steps)

mkdir -p ~/.claude/skills/vcf-variant-filtering
curl -L https://claudskills.com/skills/vcf-variant-filtering/SKILL.md \
  -o ~/.claude/skills/vcf-variant-filtering/SKILL.md

Or just download SKILL.md directly and drop it into ~/.claude/skills/vcf-variant-filtering/. Claude Code auto-discovers it on next session.

Skills live at ~/.claude/skills/vcf-variant-filtering/SKILL.md on macOS/Linux, or %USERPROFILE%\.claude\skills\vcf-variant-filtering\SKILL.md on Windows. See the full install guide for step-by-step instructions.

Pro

One-click install via the desktop app

The ClaudSkills desktop app installs any skill directly into ~/.claude/skills/ with one click — no terminal required. Pro starts at $9/mo or $149 lifetime.

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Part of ClaudSkills — the open registry for Claude Code skills. · What's New · Install guide · About · llms.txt

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