根据真实代码仓库、官网页面、运行界面、模块范围和目标软著数量，分析软件著作权（软著）申报方向，拆分可申报主题，检查 Logo、版权、备案、截图和源码等材料约束，生成 3w-4w 字正文、局部代码片段、源码原文、网页截图证据和 .docx 文档。Use when Claude needs to prepare or split legitimate…
Query NCBI ClinVar for variant clinical significance. Search by gene/position, interpret pathogenicity classifications, access via E-utilities API or FTP, annotate VCFs — from…
End-to-end metagenomics workflow from FASTQ to taxonomic and functional profiles. Covers Kraken2 classification, Bracken abundance estimation, and HUMAnN functional profi — from…
Protein grouping and inference from peptide identifications. Use when resolving protein ambiguity from shared peptides.
Generate full songs and instrumental tracks with ElevenLabs Music on RunComfy via the `runcomfy` CLI.
Generate AI images with FLUX, Gemini, Grok, Seedream, Reve and 50+ models via inference.sh CLI. Models: FLUX Dev LoRA, FLUX.2 Klein LoRA, Gemini 3 Pro Image, Grok Imagine — from…
Guide for implementing Grafana Mimir - a horizontally scalable, highly available, multi-tenant TSDB for long-term storage of Prometheus metrics.
Design robust, scalable database schemas for SQL and NoSQL databases. Provides normalization guidelines, indexing strategies, migration patterns, constraint design, and p — from…
Software architecture and UI/UX principles for building genuinely new solutions, not derivative work.
Validate GCI competition predictions and notebook outputs against expected schema, metric, and submission constraints.
Reads, inspects, and writes Flow Cytometry Standard (FCS) files from conventional, spectral, and mass cytometry (CyTOF), and parses FlowJo/Cytobank/Diva workspaces.
Guide for developing with near-api-js v7 - the JavaScript/TypeScript library for NEAR blockchain interaction.
Searches molecular libraries for substructure matches using SMARTS patterns with RDKit. Filters compounds by pharmacophore features, functional groups, or scaffold matche — from…
Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models…
Systematic writing framework for philosophy and interdisciplinary academic papers from optimized outline to submission-ready manuscript.
Use when you have a written implementation plan to execute in a separate session with review checkpoints — from bg-szy/TOP-SKILLS
Build end-to-end MLOps pipelines from data preparation through model training, validation, and production deployment.
All-in-one read preprocessing with fastp including adapter trimming, quality filtering, deduplication, base correction, and HTML report generation.
Create AI avatar and talking head videos via inference.sh CLI. Recommended: P-Video-Avatar (fastest, cheapest, built-in TTS). Also: OmniHuman, Fabric, PixVerse.
Generate AI images with FLUX, Gemini, Grok, Seedream, Reve and 50+ models via inference.sh CLI. Models: FLUX Dev LoRA, FLUX.2 Klein LoRA, Gemini 3 Pro Image, Grok Imagine — from…
Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis. — from bg-szy/TOP-SKILLS
Python patterns for system reliability — background jobs and task queues (Celery, async), resilience and recovery (retries, backoff, timeouts, circuit breakers via tenacity), and…
Local protein structure prediction with AlphaFold, Boltz, or Chai. Compare predicted structures, compute RMSD, visualise 3D models.
Performs structure-based virtual screening using AutoDock Vina 1.2 for molecular docking. Prepares receptor PDBQT files, generates ligand conformers, defines binding site boxes,…
Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile),…
Design and implement one-click post-purchase upsells and downsells that raise average order value without hurting the main conversion rate.
Reconstructs single cells from sub-cellular spatial capture units (Visium HD 2um bins, Stereo-seq DNB spots, Slide-seqV2 beads) by aggregating bins UP into cells rather than…
Impute missing genotypes using reference panels with Beagle or Minimac4. Use when increasing variant density for GWAS, harmonizing data across genotyping platforms, or in — from…
Aligns Oxford Nanopore and PacBio long reads (and assemblies) to a reference with minimap2 using the error-rate-matched preset (map-ont, lr:hq, map-hifi, map-pb, splice/splice:hq,…
Assists in writing high-quality content by conducting research, adding citations, improving hooks, iterating on outlines, and providing real-time feedback on each section — from…
Run 250+ AI apps via inference.sh CLI - image generation, video creation, LLMs, search, 3D, Twitter automation.
Detect antimicrobial resistance genes using AMRFinderPlus, ResFinder, and CARD. Screen isolates and metagenomes for resistance determinants.
Render videos from React/Remotion component code via inference.sh. Pass TSX code, get MP4. Supports all Remotion APIs: useCurrentFrame, useVideoConfig, spring, interpolat — from…
When the user wants to create, optimize, or validate URL slugs for content pages. Also use when the user mentions "URL slug," "URL path," "blog URL," "article URL," "short URL,"…
Comprehensive QA and testing skill for quality assurance, test automation, and testing strategies for ReactJS, NextJS, NodeJS applications.
Use when creating new skills, editing existing skills, or verifying skills work before deployment — from bg-szy/TOP-SKILLS
Intelligently organizes your files and folders across your computer by understanding context, finding duplicates, suggesting better structures, and automating cleanup tas — from…
Create a Natural Language Agreement escrow on-chain. Use when the user wants to lock ERC20 tokens in an escrow with a natural language demand that an AI oracle will arbit — from…
Create AI avatar, talking-head, and lip-sync videos on RunComfy via the `runcomfy` CLI. Routes across ByteDance OmniHuman (audio-driven full-body avatar), Wan-AI Wan 2-7 — from…
When the user wants to create Reddit post copy, comments, or optimize for Reddit. Also use when the user mentions "Reddit post," "subreddit," "r/," "Reddit marketing," "p — from…
When the user wants to understand or optimize for SERP feature types (PAA, sitelinks, rich results, AI Overviews).
Build production-ready Node.js backend services with Express/Fastify, implementing middleware patterns, error handling, authentication, database integration, and API desi — from…
Analyze population structure using PCA and admixture analysis with PLINK and ADMIXTURE. Identify population clusters, assess ancestry proportions, visualize genetic struc — from…
Calculate tumor mutational burden from panel or WES data with proper normalization and clinical thresholds.
Set up Prometheus for comprehensive metric collection, storage, and monitoring of infrastructure and applications.
Discovers de novo motifs and tests known motif enrichment in ChIP-seq, ATAC-seq, or other peak sequences using HOMER, MEME-ChIP (STREME, CentriMo, TOMTOM, FIMO), monaLisa, and…
Maps protein-protein and protein-ligand interfaces with Bio.PDB, computing contact residues and buried surface area (BSA).
When the user wants to create, optimize, or audit affiliate program page content. Also use when the user mentions "affiliate program," "affiliate page," "partner program,"…
Reads, writes, downloads, and converts macromolecular structures with Biopython Bio.PDB. Use when choosing a format (mmCIF/PDBx vs legacy PDB vs BinaryCIF) for a structure that…
Automate Reddit tasks via Rube MCP (Composio): search subreddits, create posts, manage comments, and browse top content. Always search tools first for current schemas.
Maps between gene identifier systems (Ensembl, Entrez, HGNC symbol, UniProt, RefSeq, MANE) using AnnotationDbi, biomaRt, mygene, pyensembl, and Ensembl REST.
Applies Anthropic's official brand colors and typography to any sort of artifact that may benefit from having Anthropic's look-and-feel.
Implement the minimal code needed to make failing tests pass in the TDD green phase. — from bg-szy/TOP-SKILLS
Use when the user asks for End-User Software Training from supplied source materials. Trigger language: end-user training; software user training; CRM training; ERP user training.
Use when implementation is complete, all tests pass, and you need to decide how to integrate the work - guides completion of development work by presenting structured opt — from…
Installs 425 bioinformatics skills covering sequence analysis, RNA-seq, single-cell, variant calling, metagenomics, structural biology, and 56 more categories.
Break a plan, spec, or the current conversation into a set of tracer-bullet tickets, each declaring its blocking edges, published to the configured tracker — edges as tex — from…
Vendor-agnostic lab automation framework. Use when controlling multiple equipment types (Hamilton, Tecan, Opentrons, plate readers, pumps) or needing unified programming — from…
Generate AI music on RunComfy via the `runcomfy` CLI. Routes to ElevenLabs Music (premium vocal, $0.0083/s) or ACE Step / 1.5 (open-weights, $0.0002–0.0003/s, multilingual), plus…
Convert files and office documents to Markdown. Supports PDF, DOCX, PPTX, XLSX, images (with OCR), audio (with transcription), HTML, CSV, JSON, XML, ZIP, YouTube URLs, EP — from…