End-to-end ATAC-seq workflow from FASTQ files to differential accessibility and TF footprinting. Covers alignment, peak calling with MACS3, QC metrics, and optional TOBIA — from…
Generate images with Google Gemini native image models via inference.sh CLI. Models: Gemini 3 Pro Image, Gemini 2.5 Flash Image.
Use when needing clinical significance, pathogenicity classifications (e.g., Pathogenic, Benign, VUS), clinical evidence rationales, or finding \"hard positive\" benchmark…
Use when starting feature work that needs isolation from current workspace or before executing implementation plans - creates isolated git worktrees with smart directory — from…
Guide through omicverse's alignment module for SRA downloading, FASTQ quality control, STAR alignment, gene quantification, and single-cell kallisto/bustools pipelines co — from…
Perform code reviews following Sentry engineering practices. Use when reviewing pull requests, examining code changes, or providing feedback on code quality.
Guides and best practices for working with Neon Serverless Postgres. Covers getting started, local development with Neon, choosing a connection method, Neon features, aut — from…
Identify spatial domains and tissue regions in spatial transcriptomics data using Squidpy and Scanpy.
Picks random winners from lists, spreadsheets, or Google Sheets for giveaways, raffles, and contests. Ensures fair, unbiased selection with transparency. — from bg-szy/TOP-SKILLS
Comprehensive variant annotation using bcftools annotate/csq, VEP, SnpEff, and ANNOVAR. Add database annotations, predict functional consequences, and assess clinical sig — from…
Call HLA alleles from NGS data using OptiType, HLA-HD, or arcasHLA for immunogenomics applications. Use when determining HLA genotype for transplant matching, neoantigen…
Cross-chain token swap integration using NEAR Intents 1Click API. Use when building swap widgets, bridge interfaces, or multi-chain transfers across EVM, Solana, NEAR, TON,…
Perform differential expression analysis using DESeq2 in R/Bioconductor. Use for analyzing RNA-seq count data, creating DESeqDataSet objects, running the DESeq workflow, and…
When the user wants to decide domain structure for multiple products or brands—subfolder vs subdomain vs independent domain.
Check and interpret data-breach exposure for an email, username, phone or name using Have I Been Pwned, the Pwned Passwords k-anonymity range API, DeHashed, IntelX and Snusbase.
Integrate applications with RouterBase, the OpenAI-compatible model gateway at https://routerbase.com/v1.
Identify domains, families, and sites in proteins; find all proteins in a family or sharing a domain; explore species distribution for a domain; annotate genomes with protein…
Compute spatial statistics for spatial transcriptomics data using Squidpy. Calculate Moran's I, Geary's C, spatial autocorrelation, co-occurrence analysis, and neighborho — from…
Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with…
When the user wants to run CTV, OTT, or streaming TV ads. Also use when the user mentions "CTV ads," "connected TV," "OTT advertising," "streaming ads," "TV ads," "Hulu ads,"…
Calculate portfolio risk metrics including VaR, CVaR, Sharpe, Sortino, and drawdown analysis. Use when measuring portfolio risk, implementing risk limits, or building ris — from…
Convert Figma or Pencil designs into production-ready frontend code using Feature-Sliced Design and Tailwind CSS v4.
Implement modern responsive layouts using container queries, fluid typography, CSS Grid, and mobile-first breakpoint strategies.
Estimate cell type composition in spatial transcriptomics spots using reference-based deconvolution. Use cell2location, RCTD, SPOTlight, or Tangram to infer cell type pro — from…
Image editing for agents: image-to-image edits, variations, and image-conditioned transforms through Image Skill's zero-setup hosted runtime.
Use when you want to look up, map, and search for short genetic variants (SNPs, indels) in NCBI's dbSNP database.
Web search and content extraction with Tavily and Exa via inference.sh CLI. Apps: Tavily Search, Tavily Extract, Exa Search, Exa Answer, Exa Extract.
Design RESTful and GraphQL APIs following best practices. Use when creating new APIs, refactoring existing endpoints, or documenting API specifications.
When the user wants to improve E-E-A-T, add trust signals, or optimize for expertise and authority. Also use when the user mentions "E-E-A-T," "E-E-A-T signals," "experience…
Linear issue tracking integration - Create, update, and manage Linear issues and projects using the GraphQL API
Professional internal communications creation and management with templates for status reports, newsletters, announcements, team updates, and cross-functional communicati — from…
Navigate protein structure hierarchy using Biopython Bio.PDB SMCRA model. Use when accessing models, chains, residues, and atoms, iterating over structure levels, or extr — from…
End-to-end workflow for detecting structural variants from long-read sequencing data. Covers ONT/PacBio alignment with minimap2 and SV calling with Sniffles or cuteSV.
Jest testing patterns, factory functions, mocking strategies, and TDD workflow. Use when writing unit tests, creating test factories, or following TDD red-green-refactor — from…
Integrate Firebase AI Logic (Gemini in Firebase) for intelligent app features. Use when adding AI capabilities to Firebase apps, implementing generative AI features, or setting up…
Defines cell populations in flow and spectral cytometry through manual gates (rectangle, polygon, quadrant, boolean) and reproducible automated gating (openCyto gating templates,…
When the user wants to create, optimize, or audit an affiliate, sponsor, or paid partnership disclosure page.
Write biological sequences to files (FASTA, FASTQ, GenBank, EMBL) using Biopython Bio.SeqIO. Use when saving sequences, creating new sequence files, or outputting modifie — from…
Design a PostgreSQL-specific schema. Covers best-practices, data types, indexing, constraints, performance patterns, and advanced features — from bg-szy/TOP-SKILLS
Adjust communication style based on whether the user is in a relational (exploratory, hedging) or transactional (direct, technical) mode.
Define and implement Service Level Indicators (SLIs) and Service Level Objectives (SLOs) with error budgets and alerting.
Find patterns, motifs, and subsequences in biological sequences using Biopython. Use when searching for transcription factor binding sites, regulatory elements, or any se — from…
Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis.
Systematically evaluate scholarly work using the ScholarEval framework, providing structured assessment across research quality dimensions including problem formulation — from…
Interpret genetic variants (SNPs) from GWAS studies by aggregating evidence from multiple databases (GWAS Catalog, Open Targets Genetics, ClinVar).
Perform pairwise sequence alignment using Biopython Bio.Align.PairwiseAligner. Use when comparing two sequences, finding optimal alignments, scoring similarity, and ident — from…
Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui).
Conduct comprehensive literature research with target disambiguation, evidence grading, and structured theme extraction.
UI/UX design intelligence. 50 styles, 21 palettes, 50 font pairings, 20 charts, 9 stacks (React, Next.js, Vue, Svelte, SwiftUI, React Native, Flutter, Tailwind, shadcn/ui — from…
Audit an Anthropic Cookbook notebook based on a rubric. Use whenever a notebook review or audit is requested. — from bg-szy/TOP-SKILLS
Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional…
Breaks down complex projects into actionable tasks with timelines, dependencies, and milestones. Use when: planning projects, creating task breakdowns, defining milestones,…
Run 250+ AI apps via inference.sh CLI - image generation, video creation, LLMs, search, 3D, Twitter automation.
Meta-agent that routes bioinformatics requests to specialised sub-skills. Handles file type detection, analysis planning, report generation, and reproducibility export.
Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools.
Configure, adjust, debug, and verify React Flow workflow nodes. Use when working on custom node components, especially for node handles, multi-channel connections, edge…
Master on-call shift handoffs with context transfer, escalation procedures, and documentation. Use when transitioning on-call responsibilities, documenting shift summaries, or…
Execute DeFi operations on Starknet including token swaps via avnu aggregator, DCA recurring buys, STRK staking, and lending/borrowing. Supports gasless transactions.
Comprehensive toolkit for developing with the CocoIndex library. Use when users need to create data transformation pipelines (flows), write custom functions, or operate f — from…
Design microservices architectures with service boundaries, event-driven communication, and resilience patterns.