Use when about to claim work is complete, fixed, or passing, before committing or creating PRs - requires running verification commands and confirming output before makin — from…
Query gnomAD for population allele frequencies to assess variant rarity. Use when filtering variants by population frequency for rare disease analysis or determining if a — from…
Execute Python code in a safe sandboxed environment via [inference.sh](https://inference.sh). Pre-installed: NumPy, Pandas, Matplotlib, requests, BeautifulSoup, Selenium — from…
Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood,…
Evaluate scientific claims and evidence quality. Use for assessing experimental design validity, identifying biases and confounders, applying evidence grading frameworks — from…
Parallel BMAD workflow orchestration using git worktrees and tmux. USE WHEN BMAD parallel, orchestrate sprint, run stories in parallel, worktree orchestration, sprint…
Find restriction enzyme cut sites in DNA sequences using Biopython Bio.Restriction. Search with single enzymes, batches of enzymes, or commercially available enzyme sets — from…
Browser automation for AI agents via inference.sh. Navigate web pages, interact with elements using @e refs, take screenshots, record video.
Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal…
Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut…
Product marketing, positioning, GTM strategy, and competitive intelligence. Includes ICP definition, April Dunford positioning methodology, launch playbooks, competitive — from…
Design multi-cloud architectures using a decision framework to select and integrate services across AWS, Azure, and GCP.
Differential abundance (DA) and differential state (DS) analysis for flow and mass cytometry - tests which cell populations change in frequency or marker expression between…
Federated variant lookup across 9 genomic databases — GWAS Catalog, Open Targets, PheWeb (UKB, FinnGen, BBJ), GTEx, eQTL Catalogue, and more.
Execute Python code in a safe sandboxed environment via [inference.sh](https://inference.sh). Pre-installed: NumPy, Pandas, Matplotlib, requests, BeautifulSoup, Selenium — from…
When the user wants indie hacker or bootstrapping founder strategy—growth, channels, Build in Public, or solo founder tactics.
Automates browser interactions for web testing, form filling, screenshots, and data extraction. Use when the user needs to navigate websites, interact with web pages, fil — from…
Video outpainting on RunComfy via the `runcomfy` CLI — extend the spatial canvas of a video, change aspect ratio (9:16 vertical to 16:9 horizontal or vice versa), add env — from…
Detects structural variants (deletions, insertions, inversions, duplications, translocations) from Oxford Nanopore and PacBio long-read alignments with Sniffles2, cuteSV, SVIM,…
Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui).
Create and manage Claude Code skills following Anthropic best practices. Use when creating new skills, modifying skill-rules.json, understanding trigger patterns, working — from…
Alpha and beta diversity analysis for microbiome data. Calculate within-sample richness, evenness, and between-sample dissimilarity with phyloseq and vegan.
Call topologically associating domains (TADs) from Hi-C data using insulation score, HiCExplorer, and other methods.
Execute Python code in a safe sandboxed environment via [inference.sh](https://inference.sh). Pre-installed: NumPy, Pandas, Matplotlib, requests, BeautifulSoup, Selenium — from…
UI design system toolkit for Senior UI Designer including design token generation, component documentation, responsive design calculations, and developer handoff tools.
Post-translational modification analysis including phosphorylation, acetylation, and ubiquitination. Covers site localization, motif analysis, and quantitative PTM analys — from…
Chunked N-D arrays for cloud storage. Compressed arrays, parallel I/O, S3/GCS integration, NumPy/Dask/Xarray compatible, for large-scale scientific computing pipelines.
When the user wants to plan, create, or repurpose visual content (images, infographics, social post images) across channels.
Gather comprehensive biological target intelligence from 9 parallel research paths covering protein info, structure, interactions, pathways, expression, variants, drug…
Build tissue and condition-specific metabolic models using GIMME, iMAT, and INIT algorithms with expression data constraints.
End-to-end single-cell RNA-seq workflow from 10X Genomics data to annotated cell types. Covers QC, normalization, clustering, marker detection, and cell type annotation — from…
Supervised and unsupervised multi-omics integration with mixOmics. Includes sPLS for pairwise integration and DIABLO for multi-block discriminant analysis.
Statistical testing for differentially abundant proteins between conditions. Covers limma and MSstats workflows with multiple testing correction.
Web accessibility specialist for WCAG compliance, ARIA implementation, and inclusive design. Use when auditing websites for accessibility issues, implementing WCAG 2.1 AA — from…
Master the uv package manager for fast Python dependency management, virtual environments, and modern Python project workflows.
Assign pathogen lineages and track variants using Nextclade and pangolin for viral surveillance. Monitor variant prevalence and identify emerging variants of concern.
Master Bash Automated Testing System (Bats) for comprehensive shell script testing. Use when writing tests for shell scripts, CI/CD pipelines, or requiring test-driven de — from…
Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers.
Git worktree workflow, conventional commits, commit trailers, and PR guidelines. Activated during git operations and commits.
Predict B-cell and T-cell epitopes using BepiPred, IEDB tools, and structure-based methods for vaccine and antibody design. Identify immunogenic regions in antigens.
Convert a finished raster image, especially a generated poster or visual resume, into an image-based PDF with an additional selectable, copyable, searchable text layer.
Game art principles. Visual style selection, asset pipeline, animation workflow. — from bg-szy/TOP-SKILLS
Statistical models library for Python. Use when you need specific model classes (OLS, GLM, mixed models, ARIMA) with detailed diagnostics, residuals, and inference.
为大学生、应届生和实习求职者从 0 创建、定制或美化可投递简历：支持借鉴 Grill Me 的一问一答访谈，从零收集经历并生成 PDF；读取岗位 JD 与旧简历，建立要求—证据映射并针对性改写；在不改变事实的前提下优化已有简历内容结构或只美化排版；按用户明确要求一次生成六种不同风格的 ATS 友好 PDF…
Unsupervised clustering and cell type identification for flow/mass cytometry. Covers FlowSOM, Phenograph, and CATALYST workflows.
Project gene annotations across genomes using TOGA (Kirilenko 2023 whole-genome-alignment chain-based projection with intactness classification), CESAR 2.0 (Sharma & Hiller 2017…
End-to-end flow, spectral, and mass cytometry (CyTOF) pipeline from raw FCS files to differentially abundant/expressed cell populations.
When the user wants to design, optimize, or audit website footers. Also use when the user mentions "footer," "page footer," "site footer," "footer links," "footer navigation,"…
Next.js 16.2.4 with TypeScript — App Router, Server Components, use cache directive, Turbopack dev, Server Actions, ISR, SSR, SSG, MCP devtools, metadata API, route handlers,…
Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and…
End-to-end time-course analysis from expression matrix to temporal patterns and enrichment. Covers temporal DE, Mfuzz soft clustering, optional rhythm detection, GAM trajectory…
Create professional research posters in LaTeX using beamerposter, tikzposter, or baposter. Support for conference presentations, academic posters, and scientific communic — from…
Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters — from…
Access AlphaFold 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (pLDDT, PAE), for drug discovery…
Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools.
Generate commit messages following project conventions for staged changes. Use when the user asks to commit changes or run /commit.
Analyzes time-series and longitudinal RNA-seq for differential expression and trajectory structure. Covers DESeq2 LRT with reduced models, time as factor vs continuous vs natural…
Use when 需要按 Alibaba Java Coding Guidelines（阿里巴巴 Java 编码规范）审查、生成或重构 Java、Spring、MyBatis、Maven、MySQL、SQL、日志、异常、安全或数据库相关代码。 — from bg-szy/TOP-SKILLS
Comprehensive multi-omics disease characterization integrating genomics, transcriptomics, proteomics, pathway, and therapeutic layers for systems-level understanding.
Guide Claude through omicverse's single-cell clustering workflow, covering preprocessing, QC, multimethod clustering, topic modeling, cNMF, and cross-batch integration as — from…