Detect A/B compartments from Hi-C data using cooltools and eigenvector decomposition. Identify active (A) and inactive (B) chromatin compartments from contact matrices.
Conduct thorough, constructive code reviews for quality and security. Use when reviewing pull requests, checking code quality, identifying bugs, or auditing security.
Test whether cell-type proportions or composition changed between conditions in single-cell data using Milo (miloR), scCODA, sccomp, and propeller.
Use when Codex, Hermes, OpenClaw, Claude Code, Cowork, or another AI agent needs to plan, review, implement, audit, or improve email work focused on Claude-assisted posit — from…
Review frontend code for accessibility, risky UI security issues, missing states, and common UX regressions.
Query gnomAD for population allele frequencies to assess variant rarity. Use when filtering variants by population frequency for rare disease analysis or determining if a — from…
Predict TCR-epitope specificity using ERGO-II and deep learning models for T-cell receptor antigen recognition.
Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus),…
End-to-end imaging mass cytometry workflow from raw acquisitions to spatial cell analysis. Orchestrates image preprocessing, segmentation, phenotyping, and spatial statis — from…
Build comprehensive attack trees to visualize threat paths. Use when mapping attack scenarios, identifying defense gaps, or communicating security risks to stakeholders.
Nominates and assesses CRISPR off-target sites genome-wide. Enumerates candidate sites by mismatch and bulge tolerance with Cas-OFFinder/CRISPRitz, ranks them with the published…
Use when implementation is complete, all tests pass, and you need to decide how to integrate the work - guides completion of development work by presenting structured opt — from…
Senior Risk Management specialist for medical device companies implementing ISO 14971 risk management throughout product lifecycle.
UI/UX design intelligence. 50 styles, 21 palettes, 50 font pairings, 20 charts, 8 stacks (React, Next.js, Vue, Svelte, SwiftUI, React Native, Flutter, Tailwind).
GitHub Pull Request作成スキル - 変更内容の自動サマリー、PR説明文生成、GitHub PRの作成を行います。git diffでの変更分析、コミットメッセージ取得、変更ファイル分類を行い、高品質なPR説明文を自動生成します。qa-check実行済みであることを前提とし、リモートへのプッシュとgh CLIによるPR作成を実行します。
Orchestrates the cell-free DNA / liquid-biopsy pipeline from plasma sequencing to tumor monitoring, forking tumor-naive (screening) vs tumor-informed (MRD), and chaining — from…
Use when creating new skills, editing existing skills, or verifying skills work before deployment — from bg-szy/TOP-SKILLS
Suggest better variable, function, and class names based on context and conventions. — from bg-szy/TOP-SKILLS
Predict B-cell and T-cell epitopes using BepiPred, IEDB tools, and structure-based methods for vaccine and antibody design. Identify immunogenic regions in antigens.
Professional internal communications creation and management with templates for status reports, newsletters, announcements, team updates, and cross-functional communicati — from…
Analyze codon usage, calculate CAI (Codon Adaptation Index), and examine synonymous codon bias using Biopython.
Structured competitive analysis with feature matrices, SWOT, positioning maps, and UX review. Covers research frameworks, pricing comparison, review mining, and visual de — from…
Create AI avatar and talking head videos with OmniHuman, Fabric, PixVerse via inference.sh CLI. Models: OmniHuman 1.5, OmniHuman 1.0, Fabric 1.0, PixVerse Lipsync.
Master C#/.NET backend development patterns for building robust APIs, MCP servers, and enterprise applications.
Gene Ontology over-representation analysis using clusterProfiler enrichGO. Use when identifying biological functions enriched in a gene list from differential expression — from…
Automated code review with security scanning, quality metrics, and best practices analysis. Use when reviewing code for: (1) Security vulnerabilities and common attack vectors,…
Identify spatial domains and tissue regions in spatial transcriptomics data using Squidpy and Scanpy.
Use when setting up environment configuration, loading .env files, or managing application settings across environments.
Run 150+ AI apps via inference.sh CLI - image generation, video creation, LLMs, search, 3D, Twitter automation.
Generate and maintain OpenAPI 3.1 specifications from code, design-first specs, and validation patterns.
Senior GDPR/DSGVO expert and internal/external auditor for data protection compliance. Provides EU GDPR and German DSGVO expertise, privacy impact assessments, data prote — from…
Detects acquired antimicrobial-resistance determinants and chromosomal point-mutation resistance in bacterial assemblies using AMRFinderPlus, ResFinder 4.0 (acquired +…
Migrate MS Teams chat content to channels or between chats. USE WHEN teams migration, migrate chat, copy messages, teams channel, move chat history, teams backup, chat to channel.
Use TweetClaw with OpenClaw to search tweets, search tweet replies, export followers, inspect users, monitor X/Twitter, and prepare reviewed post or reply actions.
When the user wants to create, optimize, or audit a giveaway, contest, or promotional campaign page. Also use when the user mentions "giveaway," "contest," "sweepstakes," "promo,"…
Master ES6+ features including async/await, destructuring, spread operators, arrow functions, promises, modules, iterators, generators, and functional programming patterns for…
Call accessible chromatin regions from ATAC-seq BAM files using MACS3, MACS2, Genrich, or HMMRATAC. Use when identifying open chromatin from aligned ATAC-seq, choosing between…
UMAP dimensionality reduction. Fast nonlinear manifold learning for 2D/3D visualization, clustering preprocessing (HDBSCAN), supervised/parametric UMAP, for high-dimensio — from…
Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools.
End-to-end CLIP-seq pipeline from FASTQ to ENCODE-compliant binding sites, single-nucleotide crosslink maps, annotation, motifs, and (optionally) differential binding.
Create production-ready Kubernetes manifests for Deployments, Services, ConfigMaps, and Secrets following best practices and security standards.
Multi-objective optimization framework. NSGA-II, NSGA-III, MOEA/D, Pareto fronts, constraint handling, benchmarks (ZDT, DTLZ), for engineering design and optimization pro — from…
Sequence QC, alignment, and BAM processing. Wraps FastQC, BWA/Bowtie2, SAMtools for automated read-to-BAM pipelines.
Generate images with Google Gemini 3.1 Flash Image Preview (Nano Banana 2) via inference.sh CLI. Capabilities: text-to-image, image editing, multi-image input (up to 14 i — from…
Generate and edit images with OpenAI GPT Image 2 (ChatGPT Images 2.0) on RunComfy. Documents GPT Image 2's strengths (embedded text, logos, multilingual typography, instr — from…
Use when Codex, Hermes, OpenClaw, Claude Code, Cowork, or another AI agent needs to plan, review, implement, audit, or improve email work focused on workflow maps, lifecy — from…
Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data.
Query protein-protein and gene interaction databases (STRING, BioGRID, IntAct, SIGNOR, Reactome, HuRI, HuMAP, OmniPath, ConsensusPathDB, DIP).
Create publication-quality visualizations of immune repertoire data including circos plots, clone tracking, diversity plots, and network graphs.
Phylogenetic tree toolkit (ETE). Tree manipulation (Newick/NHX), evolutionary event detection, orthology/paralogy, NCBI taxonomy, visualization (PDF/SVG), for phylogenomi — from…
Generate images with Google Gemini native image models via inference.sh CLI. Models: Gemini 3 Pro Image, Gemini 2.5 Flash Image.
Build production React Native apps with Expo, navigation, native modules, offline sync, and cross-platform patterns.
When the user wants to design, optimize, or audit grid layouts for content display. Also use when the user mentions "grid layout," "grid design," "multi-column grid," "CSS grid,"…
Use when receiving code review feedback, before implementing suggestions, especially if feedback seems unclear or technically questionable - requires technical rigor and — from…
Manage issues, projects & team workflows in Linear. Use when the user wants to read, create or updates tickets in Linear. — from bg-szy/TOP-SKILLS
Use when creating new skills, editing existing skills, or verifying skills work before deployment — from bg-szy/TOP-SKILLS
Evaluate scientific claims and evidence quality. Use for assessing experimental design validity, identifying biases and confounders, applying evidence grading frameworks — from…
Image outpainting on RunComfy via the `runcomfy` CLI — extend a still beyond its original canvas, fill in what the camera didn't capture, change aspect ratio (square → 16 — from…
Generate AI images with GPT-Image-2, FLUX, Gemini, Grok, Seedream, Reve and 50+ models via inference.sh CLI.
Peptide-spectrum matching and protein identification from MS/MS data. Use when identifying peptides from tandem mass spectra.