Tests genotype-environment associations and identifies adaptive loci while correcting for the four-confound landscape (structure, demography, background selection, sampling…
Intelligently organizes files and folders by understanding context, finding duplicates, and suggesting better organizational structures.
When the user wants to optimize the meta description or meta tag description. Also use when the user mentions "meta description," "meta desc," "page description," "SEO…
Maps TCR/BCR receptor sequences toward candidate antigen specificity and clusters repertoires by shared-specificity signal, while enforcing that a database match or a cluster…
Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools.
Build read models and projections from event streams. Use when implementing CQRS read sides, building materialized views, or optimizing query performance in event-sourced — from…
Analyzes experimental RNA structure probing data from SHAPE-MaP and DMS-MaPseq experiments using ShapeMapper2.
Opinionated frontend development standards for modern React + TypeScript applications. Covers Suspense-first data fetching, lazy loading, feature-based architecture, MUI v7…
Queries myvariant.info BioThings aggregator for ClinVar, gnomAD, dbSNP, dbNSFP, COSMIC, CADD, and CIViC annotations in batched, version-tracked requests.
Compare GWAS studies, perform meta-analyses, and assess replication across cohorts. Integrates NHGRI-EBI GWAS Catalog and Open Targets Genetics to compare study designs, effect…
Quick project setup with templates, best practices, and complete configuration for various framew...
Generate AI images with GPT-Image-2, FLUX, Gemini, Grok, Seedream, Reve and 50+ models via inference.sh CLI.
Visualize enrichment results using enrichplot package functions. Use when creating publication-quality figures from clusterProfiler results.
Optimize AgentDB performance with quantization (4-32x memory reduction), HNSW indexing (150x faster search), caching, and batch operations.
Build GitLab CI/CD pipelines with multi-stage workflows, caching, and distributed runners for scalable automation.
Estimates time-scaled phylogenies, molecular clock rates, effective reproduction number R_e (or R_t), and population dynamics from dated pathogen genomes using TreeTime…
Execute plan in batches with review checkpoints. Use when partner provides a complete implementation plan to execute with controlled batches and architect review between batches.
Pose-conditioned generation on RunComfy via the `runcomfy` CLI. Routes across Kling 2-6 Motion Control Pro / Standard (transfer the motion / blocking of a reference video — from…
Assesses RNA-seq data quality specifically for alternative splicing analysis. QC layers include experimental design audit (library prep, read length, depth, replicates), STAR…
De novo motif discovery and known motif enrichment analysis using HOMER and MEME-ChIP. Identify transcription factor binding motifs in ChIP-seq, ATAC-seq, or other genomi — from…
Discover, validate, and invoke .agent.md custom agents. Use when finding agent files in the local Claude or VS Code Insiders directories, checking frontmatter, verifying…
Generate AI music on RunComfy via the `runcomfy` CLI — a smart router across the music-model catalog.
Predict protein structures using modern ML models including AlphaFold3, ESMFold, Chai-1, and Boltz-1.
Git branching strategy expertise with flow-aware automation. Auto-invokes when branching strategies (gitflow, github flow, trunk-based), branch creation, branch naming, merging…
When the user wants to create, optimize, or audit blog index or listing page structure (not a single post).
Excel (.xlsx) manipulation via MCP server. Use for creating workbooks, formatting cells, writing formulas, building charts, pivot tables, data analysis, or any task involving…
Tests which individual taxa differ between groups on an amplicon ASV/feature table (phyloseq) using compositionally-aware methods - ALDEx2 (Dirichlet-MC CLR, conservative),…
Execute Python code in a safe sandboxed environment via [inference.sh](https://inference.sh). Pre-installed: NumPy, Pandas, Matplotlib, requests, BeautifulSoup, Selenium — from…
Create commit messages following Sentry conventions. Use when committing code changes, writing commit messages, or formatting git history.
Interactive Obsidian vault configurator. USE WHEN setting up obsidian vault, creating second brain, initializing knowledge base, new vault, vault bootstrap, configure obsidian,…
Search GitHub issues, pull requests, and discussions across any repository. Activates when researching external dependencies (whisper.cpp, NAudio), looking for similar bu — from…
Estimates cell-type composition from bulk DNA methylation and uses it to defuse the single biggest EWAS confounder.
Reads, queries, and writes bigWig indexed binary signal tracks (coverage, fold-change, conservation, methylation-rate) with pyBigWig (Python) and the UCSC Kent tools…
squirrelscan audits websites for SEO, performance, security, accessibility, content, and structured data issues (249+ rules) and scores site health, via the squirrel CLI.
Use when about to claim work is complete, fixed, or passing, before committing or creating PRs - requires running verification commands and confirming output before makin — from…
Use when exporting existing Azure resources to Terraform using aztfexport. Triggers on aztfexport, Azure import to Terraform, export Azure resource, bring Azure under Terraform…
Generate AI videos with Google Veo, Seedance, Wan, Grok and 40+ models via inference.sh CLI. Models: Veo 3.1, Veo 3, Seedance 1.5 Pro, Wan 2.5, Grok Imagine Video, OmniHu — from…
Coordinate software release preparation, rollout readiness, migration notes, rollback planning, stakeholder communication, and final go/no-go release packets.
Toolkit for styling artifacts with a theme. These artifacts can be slides, docs, reportings, HTML landing pages, etc.
Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui).
Modifies protein structures in place with Biopython Bio.PDB - transforms coordinates, strips waters/heteroatoms, overloads the B-factor column, renumbers, and builds entities.
Use when the user asks for Security Awareness Training from supplied source materials. Trigger language: security awareness training; cyber awareness training; employee security…
PowerPoint (.pptx) manipulation via MCP server. Use for creating slides, formatting presentations, managing placeholders, adding images, applying templates, or extracting text…
Test whether cell-type proportions or composition changed between conditions in single-cell data using Milo (miloR), scCODA, sccomp, and propeller.
End-to-end genome-scale metabolic modeling from genome sequence to flux predictions. Covers automated reconstruction with CarveMe, model validation with memote, FBA/FVA a — from…
When the user wants to find information sources for content ideation, competitor monitoring, or industry tracking.
Predict peptide-MHC class I and II binding affinity using MHCflurry and NetMHCpan neural network models. Identify potential T-cell epitopes from protein sequences.
Film and video storyboarding with shot vocabulary, continuity rules, and panel layout. Covers shot types, camera angles, movement, 180-degree rule, and annotation format — from…
Relight a still image — change the lighting setup, color temperature, direction, or mood — on RunComfy via the `runcomfy` CLI.
Test Temporal workflows with pytest, time-skipping, and mocking strategies. Covers unit testing, integration testing, replay testing, and local development setup.
Trim PCR primers from aligned reads in amplicon-panel BAMs using samtools ampliconclip. Use when processing SARS-CoV-2 ARTIC, hereditary cancer panels, ctDNA hot-spot panels, or…
Enumerates chemical libraries through reaction SMARTS transformations using RDKit. Generates virtual compound libraries from building blocks using defined chemical reactions with…
Access RCSB PDB for 3D protein/nucleic acid structures. Search by text/sequence/structure, download coordinates (PDB/mmCIF), retrieve metadata, for structural biology and — from…
Orchestrates an end-to-end CRISPR editing experiment design from target gene to delivery-ready, validatable constructs.
Detects m6A modifications from Oxford Nanopore direct-RNA-sequencing (ONT DRS) signal data using m6Anet (Hendra 2022 *Nat Methods* 19:1590; multiple-instance-learning neural…
Create portable, standards-based bioinformatics pipelines with Common Workflow Language (CWL). Use when building workflows that need maximum portability across execution — from…
NotebookLM MCP server management - query notebooks, add from share links, handle auth, reset sessions.
Multiplayer game development principles. Architecture, networking, synchronization. — from bg-szy/TOP-SKILLS
Create a topic-specific GitHub awesome-list repository scaffold with a polished README, concise contribution rules, AI-agent instructions, URL verification, license, and reusable…
Implement comprehensive testing strategies with pytest, fixtures, mocking, and test-driven development.