Estimates circulating tumor DNA fraction from shallow whole-genome sequencing using ichorCNA. Detects copy number alterations via HMM segmentation and calculates ctDNA pe — from…
Turn real customer reviews, quotes, and case-study results into polished social-proof videos built in HyperFrames -- single-testimonial spotlights, review-wall montages, and…
Type-driven design patterns in Rust - typestate, newtype, builder pattern, and compile-time guarantees — from bg-szy/TOP-SKILLS
Query PubChem via PUG-REST API/PubChemPy (110M+ compounds). Search by name/CID/SMILES, retrieve properties, similarity/substructure searches, bioactivity, for cheminforma — from…
Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocal — from…
Performs set operations on genomic intervals - intersect (-wa/-wb/-wo/-wao/-loj/-c/-v/-u), subtract (-A), merge (-d, -c/-o), complement, cluster, multiinter, unionbedg, map, and…
Predict metagenome functional content from 16S rRNA marker gene data using PICRUSt2. Infer KEGG, MetaCyc, and EC abundances from ASV tables.
Transcribe DNA to RNA and translate to protein using Biopython. Use when converting between DNA, RNA, and protein sequences, finding ORFs, or using alternative codon tabl — from…
Implement JSON-based structured logging for observability. Use when setting up logging, debugging production issues, or preparing for log aggregation (ELK, Datadog).
When the user wants to create, optimize, or audit About page content. Also use when the user mentions "about page," "about us," "company story," "our team," "about section,"…
Configure mutual TLS (mTLS) for zero-trust service-to-service communication. Use when implementing zero-trust networking, certificate management, or securing internal ser — from…
Predict TCR-epitope specificity using ERGO-II and deep learning models for T-cell receptor antigen recognition.
Comprehensive toolkit for developing with the CocoIndex library. Use when users need to create data transformation pipelines (flows), write custom functions, or operate f — from…
Pre-commit hooks framework for multi-language code quality automation. USE WHEN setting up pre-commit OR configuring git hooks OR adding linting OR code formatting OR security…
App Store and Google Play screenshot creation with exact platform specs. Covers iOS/Android dimensions, gallery ordering, device mockups, and preview videos.
Query the QuickGO and Evidence & Conclusion Ontology (ECO) REST API. Use this when you need to map genes to biological processes, molecular functions, or cellular components, find…
Execute Python code in a safe sandboxed environment via [inference.sh](https://inference.sh). Pre-installed: NumPy, Pandas, Matplotlib, requests, BeautifulSoup, Selenium — from…
Implement proven backend architecture patterns including Clean Architecture, Hexagonal Architecture, and Domain-Driven Design.
When the user wants to create, optimize, or audit migration guides for users switching from competitors.
Use when starting any conversation - establishes how to find and use skills, requiring Skill tool invocation before ANY response including clarifying questions — from…
Cell-free DNA analysis pipeline from plasma sequencing to tumor monitoring. Preprocesses cfDNA reads, analyzes fragment patterns, estimates tumor fraction from sWGS, and — from…
Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data bo — from…
Use when the user asks for End-User Software Training from supplied source materials. Trigger language: end-user training; software user training; CRM training; ERP user training.
Write biological sequences to files (FASTA, FASTQ, GenBank, EMBL) using Biopython Bio.SeqIO. Use when saving sequences, creating new sequence files, or outputting modifie — from…
JavaScript/TypeScript ES2024+, async/await, DOM manipulation, Node.js, and API integration. Use when writing vanilla JS/TS code, working with REST/fetch APIs, implementing…
When the user wants to add, optimize, or audit a top announcement bar or sticky banner. Also use when the user mentions "announcement bar," "top banner," "sticky bar," "promo…
Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 with `bam_ip` + `bam_input` (control arm) and `bam_treated_ip` +…
Trigger when the user asks for explanations of web development concepts, code breakdowns, or learning guidance.
Identify direct miRNA-target interactions from AGO HITS-CLIP, AGO-CLEAR-CLIP (chimeric reads), HEAP (Halo-Ago2 mouse), chimeric eCLIP / miR-eCLIP (deep miRNA-target profiling), or…
Quantifies biodiversity from species abundance/incidence tables using Hill numbers (iNEXT) with coverage-based rarefaction-extrapolation (Chao & Jost 2012), asymptotic richness…
Run Bayesian phylogenetic analysis with MrBayes, BEAST2, RevBayes, and PhyloBayes including MCMC convergence diagnostics and model comparison.
Alpha and beta diversity analysis for microbiome data. Calculate within-sample richness, evenness, and between-sample dissimilarity with phyloseq and vegan.
Estimates circulating tumor DNA fraction from shallow whole-genome sequencing using ichorCNA. Detects copy number alterations via HMM segmentation and calculates ctDNA pe — from…
Analyzes cfDNA methylation patterns for cancer detection using cfMeDIP-seq or bisulfite sequencing with MethylDackel.
Generates, normalizes, and converts bedGraph signal tracks (4-column chrom/start/end/value, 0-based half-open) with bedtools genomecov, deepTools…
Preprocess ribosome profiling data including adapter trimming, size selection, rRNA removal, and alignment.
Extend or continue an existing video clip on RunComfy via the `runcomfy` CLI. Routes to Google Veo 3-1's `extend-video` and `fast/extend-video` endpoints — pick the sourc — from…
Generate commit message, PR title, and PR body for a pull request. Use when the user wants to create a PR, generate PR content, prepare a pull request, or fill a PR template from…
Automates browser interactions for web testing, form filling, screenshots, and data extraction. Use when the user needs to navigate websites, interact with web pages, fil — from…
Generate AI videos on RunComfy via the `runcomfy` CLI — a smart router across the full video-model catalog: HappyHorse 1.0 (Arena #1, native in-pass audio), Wan-AI Wan 2- — from…
Official Opentrons Protocol API for OT-2 and Flex robots. Use when writing protocols specifically for Opentrons hardware with full access to Protocol API v2 features.
Implement state management patterns for frontend applications. Use when managing global state, handling complex data flows, or coordinating state across components.
Internet Court adapter for GenLayer Intelligent Contract supervision. Use to specify agent-performance rubrics, evidence schemas, decision outputs, and ERC-7710 connector — from…
Assembles a genome de novo from Illumina short reads with SPAdes (isolate/careful/sc/meta/plasmid/rna modes), MEGAHIT (low-memory, huge datasets), Unicycler (bacterial…
Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol),…
Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE)…
Build GitLab CI/CD pipelines with multi-stage workflows, caching, and distributed runners for scalable automation.
Detect and fix design drift — the ad-hoc colors, spacing, type sizes, shadows, and duplicate component variants that accumulate outside the design system and harden into debt.
Query the STRING database for protein-protein interactions (PPIs), functional enrichment, and homology.
Benchling R&D platform integration. Access registry (DNA, proteins), inventory, ELN entries, workflows via API, build Benchling Apps, query Data Warehouse, for lab data m — from…
Automate Twitter/X with posting, engagement, and user management via inference.sh CLI. Apps: x/post-tweet, x/post-create (with media), x/post-like, x/post-retweet, x/dm-s — from…
Download, prepare, and manage reference panels for phasing and imputation. Covers 1000 Genomes, HRC, and TOPMed panels.
Convert a finished raster image, especially a generated poster or visual resume, into an image-based PDF with an additional selectable, copyable, searchable text layer.
Gene Ontology over-representation analysis using clusterProfiler enrichGO. Use when identifying biological functions enriched in a gene list from differential expression — from…
Query the Genome Aggregation Database (gnomAD). Use when determining the rarity or allele frequency of specific genetic variants, retrieving gene constraint metrics (pLI, LOEUF)…
Generate and publish a project status artifact — an opinionated, tabbed status page for a project too big for one update (overview & success criteria, the workstream sequence,…
Designs and defends an epigenome-wide association study (EWAS) on 450K/EPIC array or bisulfite methylation - the layer deciding whether a hit is credible.
Walk through omicverse's single-cell preprocessing tutorials to QC PBMC3k data, normalise counts, detect HVGs, and run PCA/embedding pipelines on CPU, CPU–GPU mixed, or G — from…
Render videos from React/Remotion component code via inference.sh. Pass TSX code, get MP4. Supports all Remotion APIs: useCurrentFrame, useVideoConfig, spring, interpolat — from…
Automate Twitter/X with posting, engagement, and user management via inference.sh CLI. Apps: x/post-tweet, x/post-create (with media), x/post-like, x/post-retweet, x/dm-s — from…