Generate and interpret quality reports from FASTQ files using FastQC and MultiQC. Assess per-base quality, adapter content, GC bias, duplication levels, and overrepresent — from…
Detects differential alternative splicing between conditions using rMATS-turbo (BAM-based) or SUPPA2 diffSplice (TPM-based).
Perform V(D)J alignment and clonotype assembly from TCR-seq or BCR-seq data using MiXCR. Use when processing raw immune repertoire sequencing data to identify clonotypes — from…
Differential abundance testing for microbiome data using compositionally-aware methods like ALDEx2, ANCOM-BC2, and MaAsLin2.
Executive leadership guidance for strategic decision-making, organizational development, and stakeholder management.
Creates DE-specific diagnostic and result visualizations using DESeq2/edgeR built-in functions and lightweight ggplot2 wrappers.
Mobile game development principles. Touch input, battery, performance, app stores. — from bg-szy/TOP-SKILLS
Toolkit for styling artifacts with a theme. These artifacts can be slides, docs, reportings, HTML landing pages, etc.
macOS development environment setup wizard. Interactive Q&A to collect preferences, auto-detect installed software, generate customized installation plan.
Use when encountering any bug, test failure, or unexpected behavior, before proposing fixes - four-phase framework (root cause investigation, pattern analysis, hypothesis — from…
Reconstructs single cells from sub-cellular spatial capture units (Visium HD 2um bins, Stereo-seq DNB spots, Slide-seqV2 beads) by aggregating bins UP into cells rather than…
Authentication and access control skill for Next.js 15 + Supabase applications. Use when implementing user authentication, protecting routes, managing user sessions, enforcing…
When the user wants to run display, banner, or ad network campaigns. Also use when the user mentions "display ads," "banner ads," "ad network," "ad alliance," "programmatic…
Comprehensive toolkit for product managers including RICE prioritization, customer interview analysis, PRD templates, discovery frameworks, and go-to-market strategies.
MS-DIAL-based metabolomics preprocessing as alternative to XCMS. Covers peak detection, alignment, annotation, and export for downstream analysis.
Analyzes cfDNA fragment size distributions and fragmentomics features using FinaleToolkit or Griffin.
Publication-quality visualizations for biomedical and genomics data. Use when creating volcano plots, heatmaps, UMAP plots, dot plots, survival curves, forest plots, or…
Complete code review workflow for both requesting and receiving reviews. Use when creating PRs, reviewing code, or responding to feedback.
WikiPathways enrichment using clusterProfiler and rWikiPathways. Use when analyzing gene lists against community-curated open-source pathways.
Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers.
Master advanced Git workflows including rebasing, cherry-picking, bisect, worktrees, and reflog to maintain clean history and recover from any situation.
Computes and interprets sequencing read depth and coverage over a genome, windows, or target regions with mosdepth (windowed depth, cumulative distribution, --quantize callable…
Transform podcast transcripts into comprehensive content marketing suites including blog posts, social media content, newsletters, SEO-optimized articles, and timestamps — from…
Daily inbox triage using Cowork's email write tools (Microsoft 365 or Gmail) -- classifies unread mail, drafts replies in your voice, flags what needs a decision, and schedules…
Test web applications with screen readers including VoiceOver, NVDA, and JAWS. Use when validating screen reader compatibility, debugging accessibility issues, or ensuring…
Generates creative domain name ideas for your project and checks availability across multiple TLDs (.com, .io, .dev, .ai, etc.).
Turborepo monorepo build system guidance. Triggers on: turbo.json, task pipelines, dependsOn, caching, remote cache, the "turbo" CLI, --filter, --affected, CI optimizatio — from…
Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools.
Modern SwiftUI toolbar patterns including customizable toolbars, search integration, transition effects, and platform-specific behavior.
Combine vector and keyword search for improved retrieval. Use when implementing RAG systems, building search engines, or when neither approach alone provides sufficient r — from…
Guide for Grafana Pyroscope continuous profiling. Use for Kubernetes Helm deployment, Go/Java/Python/.NET/Ruby/Node.js profiling, storage backends, trace-to-profile linking, and…
Use when creating new skills, editing existing skills, or verifying skills work before deployment - applies TDD to process documentation by testing with subagents before — from…
Senior FDA consultant and specialist for medical device companies including HIPAA compliance and requirement management.
Quality control metrics for ATAC-seq data including fragment size distribution, TSS enrichment, FRiP, and library complexity.
Use when creating new skills, editing existing skills, or verifying skills work before deployment — from bg-szy/TOP-SKILLS
Bead-based signal normalization and cross-batch harmonization for CyTOF and high-parameter cytometry - EQ four-element bead normalization of instrument sensitivity drift (CATALYST…
Data-independent acquisition (DIA) proteomics analysis with DIA-NN and other tools. Use when analyzing DIA mass spectrometry data with library-free or library-based workf — from…
Perform comprehensive code reviews covering security, style, performance, and best practices. Use when reviewing code changes before commit or merge, auditing existing code, or…
Multi-agent workflow examples to work together on the OpenServ Platform. Covers agent discovery, multi-agent workspaces, task dependencies, and workflow orchestration usi — from…
When the user wants to run CTV, OTT, or streaming TV ads. Also use when the user mentions "CTV ads," "connected TV," "OTT advertising," "streaming ads," "TV ads," "Hulu ads,"…
Enumerates virtual chemical libraries via reaction SMARTS transformations using RDKit and Reaction templates, with explicit handling of atom mapping, template extraction (RDKit…
Search, browse, and install animated React components from ReactBits.dev (135+ components). Use when the user wants to add UI effects, animations, backgrounds, or interactive…
Google quantum computing framework. Use when targeting Google Quantum AI hardware, designing noise-aware circuits, or running quantum characterization experiments.
Calculates molecular fingerprints (ECFP/Morgan, FCFP, MACCS, RDKit, AtomPair, TopologicalTorsion, Avalon, MAP4, MHFP6) and physicochemical descriptors (Lipinski, QED, TPSA,…
Run 150+ AI apps via inference.sh CLI - image generation, video creation, LLMs, search, 3D, Twitter automation.
Predict CRISPR off-target sites using Cas-OFFinder and CFD scoring algorithms. Identify potential unintended cleavage sites genome-wide and assess guide specificity.
QuantAll（全A解析）MCP —— 股市全市场向量化计算引擎，为 AI 提供本地 Python 计算环境。 AI 编写向量化代码片段，数秒内完成 5000+ 股票的因子计算、策略回测、IC 分析和 GPU 可视化。 让 AI 从"信息查询者"升级为"数据计算者"——用代码算出客观结果，而非搬运网络观点。…
Protein grouping and inference from peptide identifications. Use when resolving protein ambiguity from shared peptides.
Analyze high-resolution spatial platforms like Slide-seq, Stereo-seq, and Visium HD. Use when working with subcellular resolution or high-density spatial data.
Use for explicit undergraduate data-science teaching, assignment guidance, concept clarification, method selection, or output interpretation.
Use when encountering any bug, test failure, or unexpected behavior, before proposing fixes. Four-phase framework ensuring understanding before attempting solutions.
When the user wants to find information sources for content ideation, competitor monitoring, or industry tracking.
Rapid pathogen characterization and drug repurposing analysis for infectious disease outbreaks. Identifies pathogen taxonomy, essential proteins, predicts structures, and screens…
Convert content between platforms (blog to Twitter thread, article to LinkedIn post, etc.). Optimize for each platform's format, tone, and best practices.
SwiftUI text styling and rich text editing patterns. Use when displaying styled text, building rich text editors, working with AttributedString, implementing TextEditor with…
Context optimization extends the effective capacity of limited context windows through strategic compression, masking, caching, and partitioning.
Comprehensive backend development skill for building scalable backend systems using NodeJS, Express, Go, Python, Postgres, GraphQL, REST APIs.
Queries myvariant.info BioThings aggregator for ClinVar, gnomAD, dbSNP, dbNSFP, COSMIC, CADD, and CIViC annotations in batched, version-tracked requests.
Scoring framework for test-kitchen cookoff and omakase-off. Invoked at Phase 4 to evaluate implementations using 5-criteria scoring.
Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue),…