Spatial analysis of cell neighborhoods and interactions in IMC data. Covers neighbor graphs, spatial statistics, and interaction testing.
Calculate sequence statistics (N50, length distribution, GC content, summary reports) using Biopython.
Design, organize, and manage Helm charts for templating and packaging Kubernetes applications with reusable configurations.
Query the STRING database for protein-protein interactions (PPIs), functional enrichment, and homology.
Phases small variants, SVs, and methylation from Oxford Nanopore and PacBio long reads (read-backed/physical phasing) with WhatsHap, LongPhase, or HiPhase, and haplotags the BAM…
Automates browser interactions for web testing, form filling, screenshots, and data extraction. Use when the user needs to navigate websites, interact with web pages, fil — from…
Implement proven backend architecture patterns including Clean Architecture, Hexagonal Architecture, and Domain-Driven Design.
Use when first encountering an unknown binary, ELF file, executable, or firmware blob. Fast fingerprinting via rabin2 - architecture detection (ARM, x86, MIPS), ABI ident — from…
Detects and removes infostealer malware (credential stealers, data exfiltrators) via full-system file search, cryptographic hashing, and public threat-intelligence cross-checks…
Analyze time-series RNA-seq data using limma voom with splines, maSigPro, and ImpulseDE2. Identify genes with dynamic expression patterns.
Imports gene expression count matrices from featureCounts, HTSeq, STAR ReadsPerGene, Salmon/kallisto via tximport or tximeta, RSEM, 10X Genomics MTX/H5, AnnData H5AD, and RDS.
Process multiple sequence files in batch using Biopython. Use when working with many files, merging/splitting sequences, or automating file operations across directories.
Ultra-compressed communication mode. Cuts token usage ~75% by dropping filler, articles, and pleasantries while keeping full technical accuracy.
When the user wants to reduce churn, improve customer retention, or plan lifecycle marketing. Also use when the user mentions "retention," "churn," "customer lifecycle," "churn…
Use this umbrella skill when the request spans multiple AltLLM Portal CLI domains, or when you need to navigate the local altllm CLI in this repository across auth, API k — from…
Reactome pathway enrichment using ReactomePA package. Use when analyzing gene lists against Reactome's curated peer-reviewed pathway database.
Execute autonomous multi-step research using Google Gemini Deep Research Agent. Use for: market analysis, competitive landscaping, literature reviews, technical research — from…
Calculate translation efficiency (TE) as the ratio of ribosome occupancy to mRNA abundance. Use when comparing translational regulation between conditions or identifying — from…
Use when receiving code review feedback, before implementing suggestions, especially if feedback seems unclear or technically questionable - requires technical rigor and — from…
Install a fast local task workflow for single-project planning with `scripts/task.sh` (claim, done, status, reporting) backed by `tasks/TASKS.md` and optional `tasks/details/`…
Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2 — from…
Frontend development guidelines for React/TypeScript applications. Modern patterns including Suspense, lazy loading, useSuspenseQuery, file organization with features dir — from…
Design qPCR primers and TaqMan/molecular beacon probes using primer3-py. Configure probe Tm, primer-probe spacing, and hydrolysis probe constraints for real-time PCR assa — from…
Calculate sequence properties like GC content, molecular weight, isoelectric point, and GC skew using Biopython.
Extract methylation calls from Bismark BAM files using bismark_methylation_extractor. Generates per-cytosine reports for CpG, CHG, and CHH contexts.
Build automated billing systems for recurring payments, invoicing, subscription lifecycle, and dunning management.
Create publication-quality visualizations of immune repertoire data including circos plots, clone tracking, diversity plots, and network graphs.
\"Tool lifecycle UI components for React/Next.js from ui.inference.sh. Display tool calls: pending, progress, approval required, results.
Automate Twitter/X with posting, engagement, and user management via inference.sh CLI. Apps: x/post-tweet, x/post-create (with media), x/post-like, x/post-retweet, x/dm-s — from…
Use when creating or developing anything, before writing code or implementation plans - refines rough ideas into fully-formed designs through structured Socratic questioning,…
QuantAll（全A解析）MCP —— 股市全市场向量化计算引擎，为 AI 提供本地 Python 计算环境。 AI 编写向量化代码片段，数秒内完成 5000+ 股票的因子计算、策略回测、IC 分析和 GPU 可视化。 让 AI 从"信息查询者"升级为"数据计算者"——用代码算出客观结果，而非搬运网络观点。…
Reactome pathway enrichment using ReactomePA package. Use when analyzing gene lists against Reactome's curated peer-reviewed pathway database.
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI…
Region edits across video frames on RunComfy via the `runcomfy` CLI — remove an object that appears across many frames, clean up wires or watermarks, replace a region wit — from…
Use when starting any conversation - establishes how to find and use skills, requiring Skill tool invocation before ANY response including clarifying questions — from…
Search and retrieve clinical practice guidelines across 12+ authoritative sources including NICE, WHO, ADA, AHA/ACC, NCCN, SIGN, CPIC, CMA, CTFPHC, GIN, MAGICapp, PubMed,…
Schedule alarms and countdown timers in iOS apps using AlarmKit. Use when implementing alarm functionality, timer features, AlarmKit integration, snooze/stop controls, Dynamic…
Mask-driven image inpainting on RunComfy via the `runcomfy` CLI. Routes to Tongyi MAI Z-Image Turbo Inpainting (the dedicated inpainting endpoint with mask, strength, and — from…
Use when Codex, Hermes, OpenClaw, Claude Code, Cowork, or another AI agent needs to plan, review, implement, audit, or improve email work focused on open, inspectable ema — from…
Query myvariant.info API for aggregated variant annotations from multiple databases (ClinVar, gnomAD, dbSNP, COSMIC, etc.) in a single request.
Edit images with Google Nano Banana 2 (image-to-image edit endpoint) on RunComfy. Documents Nano Banana Edit's strengths (preserve subject identity, swap background, loca — from…
Connect GenLayer Intelligent Contract decisions to ERC-7710-style delegated authority. Use when an agent needs to design the interface, message schema, relayer/bridge pat — from…
Sort alignment files by coordinate or read name using samtools and pysam. Use when preparing BAM files for indexing, variant calling, or paired-end analysis.
Investigator OPSEC — threat-model who might notice you, control your attribution surface across IP, ASN, browser and TLS fingerprint, timing and logged-in accounts, separate…
Constructs and validates polygenic risk scores using LDpred2-auto, SBayesRC, MegaPRS, PRS-CS, PROSPER, MUSSEL, BridgePRS, JointPRS, PRSmix, or PGS Catalog Calculator with…
Inspect PDFs, DOCX, PPTX, and XLSX files for share-readiness, metadata, links, comments, and hidden content.
When the user wants to create, optimize, or audit a feedback or roadmap page. Also use when the user mentions "feedback page," "roadmap," "feature requests," "vote on features,"…
Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution…
Cowork-style cleanup of a messy folder or shared drive -- classifies every file, proposes a target structure, renames to a consistent convention, deduplicates, and writes an…
Query Open Targets Platform for target-disease associations, drug target discovery, tractability/safety data, genetics/omics evidence, known drugs, for therapeutic target — from…
Comprehensive project planning and documentation generator for software projects. Creates structured requirements documents, system design documents, and task breakdown p — from…
Detect and remove doublets (two or more cells in one droplet) from single-cell RNA-seq using scDblFinder (R), Scrublet (Python), and DoubletFinder (R).
Performs time-to-event analysis for clinical trials including Cox proportional hazards regression with PH diagnostics, restricted mean survival time (RMST) under non-PH, competing…
Automate Twitter/X with posting, engagement, and user management via inference.sh CLI. Apps: x/post-tweet, x/post-create (with media), x/post-like, x/post-retweet, x/dm-s — from…
Profile and optimize Python code using cProfile, memory profilers, and performance best practices. Use when debugging slow Python code, optimizing bottlenecks, or improvi — from…
Unified Python interface to 40+ bioinformatics services. Use when querying multiple databases (UniProt, KEGG, ChEMBL, Reactome) in a single workflow with consistent API — from…
Implement semantic vector search with AgentDB for intelligent document retrieval, similarity matching, and context-aware querying.
Audit a browser fingerprint for internal contradictions with the liarjs CLI - canvas, WebGL, WebGL2, WebGPU, audio, 220 fonts, WebRTC and timezone probes, scored against the…
Use when implementation is complete, all tests pass, and you need to decide how to integrate the work - guides completion of development work by presenting structured opt — from…
Runs RNA-seq-specific post-alignment QC - strandedness inference, gene-body 5'-3' coverage, read distribution (exonic/intronic/intergenic), rRNA/globin/mitochondrial rate,…