Chunked N-D arrays for cloud storage. Compressed arrays, parallel I/O, S3/GCS integration, NumPy/Dask/Xarray compatible, for large-scale scientific computing pipelines.
Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio.
Agile product ownership toolkit for Senior Product Owner including INVEST-compliant user story generation, sprint planning, backlog management, and velocity tracking.
Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments,…
Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA…
Process and analyze tissue images from spatial transcriptomics data using Squidpy. Extract image features, segment cells/nuclei, and compute morphological features from H — from…
Detect and analyze adverse drug event signals using FDA FAERS data, drug labels, disproportionality analysis (PRR, ROR, IC), and biomedical evidence.
通过 CLI 查询 Datadata — 运行临时 SQL、检查数据源元数据、列表和描述表、下载 NDJSON/CSV 格式结果。当用户提到 Datadata、想查询数据、探索数据源或表 schema、获取查询结果时使用此 skill。触发：Datadata、数据探索、SQL查询、表检查、执行结果。
Edit images with OpenAI GPT Image 2 (the `/edit` endpoint of ChatGPT Images 2.0) on RunComfy — bundled with the model's documented prompting patterns so the skill gets sh — from…
When the user wants to add, optimize, or audit popups or modals for lead capture or offers. Also use when the user mentions "popup," "modal," "lightbox," "overlay," "exit-intent,"…
Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage — from…
Look up current research information using Perplexity Sonar Pro Search or Sonar Reasoning Pro models through OpenRouter.
Metabolite identification from m/z and retention time. Covers database matching, MS/MS spectral matching, and confidence level assignment.
Master end-to-end testing with Playwright and Cypress to build reliable test suites that catch bugs, improve confidence, and enable fast deployment.
Generate, inpaint, and outpaint music with ACE Step on RunComfy via the `runcomfy` CLI. ACE Step is StepFun-AI's open-weights music foundation model — tag-driven composition…
Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments.
Statistical testing for differentially abundant proteins between conditions. Covers limma and MSstats workflows with multiple testing correction.
Perform in silico gene knockout analysis and synthetic lethality screens using COBRApy single and double deletions.
Patiently AI simplifies medical documents for patients. Takes doctor's letters, test results, prescriptions, discharge summaries, and clinical notes and explains them in clear,…
Implement semantic vector search with AgentDB for intelligent document retrieval, similarity matching, and context-aware querying.
Senior Quality Documentation Manager for comprehensive documentation control and regulatory document review.
Build robust backtesting systems for trading strategies with proper handling of look-ahead bias, survivorship bias, and transaction costs.
Analyzes base editing and prime editing outcomes including editing efficiency, bystander edits, and indel frequencies.
Configure Istio traffic management including routing, load balancing, circuit breakers, and canary deployments.
Query Reactome REST API for pathway analysis, enrichment, gene-pathway mapping, disease pathways, molecular interactions, expression analysis, for systems biology studies — from…
Production-ready patterns and best practices for MCP servers - architecture, security, performance, and maintenance — from bg-szy/TOP-SKILLS
Configure Static Application Security Testing (SAST) tools for automated vulnerability detection in application code.
Estimate cell type composition in spatial transcriptomics spots using reference-based deconvolution. Use cell2location, RCTD, SPOTlight, or Tangram to infer cell type pro — from…
Production-ready RNA-seq differential expression analysis using PyDESeq2. Performs DESeq2 normalization, dispersion estimation, Wald testing, LFC shrinkage, and result filtering.
Use when starting any conversation - establishes how to find and use skills, requiring Skill tool invocation before ANY response including clarifying questions — from…
Senior Risk Management specialist for medical device companies implementing ISO 14971 risk management throughout product lifecycle.
Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven…
Download, prepare, and manage reference panels for phasing and imputation. Covers 1000 Genomes, HRC, and TOPMed panels.
Technical leadership guidance for engineering teams, architecture decisions, and technology strategy.
Master effective code review practices to provide constructive feedback, catch bugs early, and foster knowledge sharing while maintaining team morale.
Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS,…
Filter reads by quality scores, length, and N content using Trimmomatic and fastp. Apply sliding window trimming, remove low-quality bases from read ends, and discard rea — from…
Design effective KPI dashboards with metrics selection, visualization best practices, and real-time monitoring patterns.
Use when you need to run a binary, trace execution, or observe runtime behavior. Runtime analysis via QEMU emulation, GDB debugging, and Frida hooking - syscall tracing ( — from…
Handle paired-end FASTQ files (R1/R2) using Biopython. Use when working with Illumina paired reads, synchronizing pairs, interleaving/deinterleaving, or filtering paired — from…
Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and…
Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and…
Filter reads by quality scores, length, and N content using Trimmomatic and fastp. Apply sliding window trimming, remove low-quality bases from read ends, and discard rea — from…
Render videos from React/Remotion component code via inference.sh. Pass TSX code, get MP4. Supports all Remotion APIs: useCurrentFrame, useVideoConfig, spring, interpolat — from…
When the user wants to reduce churn, improve customer retention, or plan lifecycle marketing. Also use when the user mentions "retention," "churn," "customer lifecycle," "churn…
Structured hypothesis formulation from observations. Use when you have experimental observations or data and need to formulate testable hypotheses with predictions, propo — from…
Deep learning-based variant calling with Google DeepVariant. Provides high accuracy for germline SNPs and indels from Illumina, PacBio, and ONT data.
Build, manage, and search spectral libraries for proteomics. Use when creating or working with spectral libraries for DIA analysis.
Create and train AI learning plugins with AgentDB's 9 reinforcement learning algorithms. Includes Decision Transformer, Q-Learning, SARSA, Actor-Critic, and more.
Taxonomic classification of metagenomic reads using Kraken2. Fast k-mer based classification against RefSeq database.
Generate comprehensive, developer-friendly API documentation from code, including endpoints, parameters, examples, and best practices — from bg-szy/TOP-SKILLS
Download raw sequencing reads from NCBI SRA using sra-tools (prefetch, fasterq-dump, vdb-validate) or the ENA mirror.
Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis.
Design guide RNAs for CRISPR-Cas9/Cas12a experiments using CRISPRscan and local scoring algorithms. Score guides for on-target activity using Rule Set 2 and Azimuth model — from…
Configure and optimize Nx monorepo workspaces. Use when setting up Nx, configuring project boundaries, optimizing build caching, or implementing affected commands.
Integrate multiple scRNA-seq samples/batches using Harmony, scVI, Seurat anchors, and fastMNN. Remove technical variation while preserving biological differences.
Generate and maintain OpenAPI 3.1 specifications from code, design-first specs, and validation patterns.
Expert at TSDoc comments, Storybook stories, VitePress docs, TypeDoc API generation. Use when documenting code, adding comments, creating stories, or generating API docs.
Calculate alignment statistics including sequence identity, conservation scores, substitution matrices, and similarity metrics.
End-to-end metabolomics workflow from raw MS data to pathway analysis. Orchestrates XCMS preprocessing, annotation, normalization, statistical analysis, and pathway mappi — from…