Gene and region-based rare-variant aggregation - burden/collapsing, SKAT, SKAT-O, ACAT-V/ACAT-O, annotation-weighted STAAR - with regenie (--vc-tests), SAIGE-GENE+, and t — from…
Generate AI images with GPT-Image-2, FLUX, Gemini, Grok, Seedream, Reve and 50+ models via inference.sh CLI.
Use when starting any conversation - establishes how to find and use skills, requiring Skill tool invocation before ANY response including clarifying questions — from…
Master end-to-end testing with Playwright and Cypress to build reliable test suites that catch bugs, improve confidence, and enable fast deployment.
When the user wants to optimize for Featured Snippets, Position Zero, or snippet extraction. Also use when the user mentions "featured snippet," "position zero," "snippet…
Filter and select sequences by criteria (length, ID, GC content, patterns) using Biopython. Use when subsetting sequences, removing unwanted records, or selecting by spec — from…
When the user wants to create, optimize, or audit glossary page content and structure. Also use when the user mentions "glossary," "definitions," "terminology," "industry terms,"…
Master SQL query optimization, indexing strategies, and EXPLAIN analysis to dramatically improve database performance and eliminate slow queries.
Enforce RED-GREEN-REFACTOR cycle. Use when implementing features, fixing bugs, or writing any production code.
Create new Claude Code Skills with proper YAML frontmatter, progressive disclosure structure, and complete directory organization.
Sweep your folders and downloads for tax documents and build a CPA-ready package -- checklist by form type, everything renamed and organized, a missing-document chase list, and…
When the user wants to optimize URL structure, fix URL issues, or plan URL hierarchy. Also use when the user mentions "URL structure," "URL optimization," "slug," "clean URLs,"…
Query openFDA API for drugs, devices, adverse events, recalls, regulatory submissions (510k, PMA), substance identification (UNII), for FDA regulatory data analysis and s — from…
Create a source-grounded interactive digital-human SaaS or software product explainer that website visitors can question and embed through PersonWise.
Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL.
Analyzes experimental RNA structure probing data from SHAPE-MaP and DMS-MaPseq experiments using ShapeMapper2.
YouTube thumbnail design with specific dimensions, contrast rules, and mobile preview optimization. Covers safe zones, text placement, face expression psychology, and A/B — from…
Read, write, and convert phylogenetic tree files using Biopython Bio.Phylo. Use when parsing Newick, Nexus, PhyloXML, or NeXML tree formats, converting between formats, o — from…
Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools.
ChIP-seq peak calling using MACS3 (or MACS2). Call narrow peaks for transcription factors or broad peaks for histone modifications.
Create detailed implementation plans with granular tasks. Use before implementing features or complex changes.
RNA-seq specific quality control including rRNA contamination detection, strandedness verification, gene body coverage, and transcript integrity metrics.
Detect and track antimicrobial resistance genes using AMRFinderPlus and ResFinder with epidemiological context.
Design and implement event stores for event-sourced systems. Use when building event sourcing infrastructure, choosing event store technologies, or implementing event per — from…
Use when the user asks for Product Change Adoption Course from supplied source materials. Trigger language: product update; feature adoption; migration guide; breaking change;…
Systematic debugging and root cause analysis for identifying and fixing software issues. Use when: debugging errors, troubleshooting bugs, investigating crashes, analyzing stack…
Analyze protein-protein interaction networks using STRING, BioGRID, and SASBDB databases. Maps protein identifiers, retrieves interaction networks with confidence scores, performs…
Jest testing patterns, factory functions, mocking strategies, and TDD workflow. Use when writing unit tests, creating test factories, or following TDD red-green-refactor — from…
Chooses the enrichment generation before any tool runs, mapping the input shape to a method class - a pre-selected gene list plus a background to over-representation analysis…
View, query, and understand VCF/BCF variant files using bcftools and cyvcf2. Use when inspecting variants, extracting specific fields, or understanding VCF format structu — from…
Create well-formatted git commits with conventional commit messages and emoji. Use when user asks to commit changes, save work, or after completing a task that should be committed.
Implement persistent memory patterns for AI agents using AgentDB. Includes session memory, long-term storage, pattern learning, and context management.
End-to-end metabolomics workflow from raw MS data to pathway analysis. Orchestrates XCMS preprocessing, annotation, normalization, statistical analysis, and pathway mappi — from…
Analyze single-cell TCR and BCR data integrated with gene expression using scirpy. Use when working with 10x Genomics VDJ data alongside scRNA-seq or when integrating imm — from…
When the user wants to create, optimize, or audit customer stories or case study pages. Also use when the user mentions "case studies," "customer stories," "success stories,"…
Audit and sync design tokens between the source of truth (tokens.json, Figma variables export) and the code that should consume them (Tailwind config, CSS custom properties, theme…
Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution…
Run 150+ AI apps via inference.sh CLI - image generation, video creation, LLMs, search, 3D, Twitter automation.
Convert between sequence file formats (FASTA, FASTQ, GenBank, EMBL) using Biopython Bio.SeqIO. Use when changing file formats or preparing data for different tools.
Calculate tumor mutational burden from panel or WES data with proper normalization and clinical thresholds.
Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles,…
Mask-driven image inpainting on RunComfy via the `runcomfy` CLI. Routes to Tongyi MAI Z-Image Turbo Inpainting (the dedicated inpainting endpoint with mask, strength, and — from…
Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with…
Convert an existing frontend into Stitch-ready design assets by extracting static HTML, writing DESIGN.md, creating the design system, and uploading approved files.
Use when doing ANY task involving Supabase. Triggers: Supabase products (Database, Auth, Edge Functions, Realtime, Storage, Vectors, Cron, Queues); client libraries and S — from…
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs…
Detect ribosome pausing and stalling sites from Ribo-seq data at codon resolution. Use when studying translational regulation, identifying pause sites, or analyzing codon — from…
Write competitive research proposals for NSF, NIH, DOE, DARPA, and Taiwan NSTC. Agency-specific formatting, review criteria, budget preparation, broader impacts, signific — from…
Review UI code for Web Interface Guidelines compliance. Use when asked to "review my UI", "check accessibility", "audit design", "review UX", or "check my site against be — from…
Statistical methods for calling hits in CRISPR screens. Covers MAGeCK, BAGEL2, drugZ, and custom approaches for identifying essential and resistance genes.
Read, write, and convert multiple sequence alignment files using Biopython Bio.AlignIO. Supports Clustal, PHYLIP, Stockholm, FASTA, Nexus, and other alignment formats for — from…
Access ClinPGx pharmacogenomics data (successor to PharmGKB). Query gene-drug interactions, CPIC guidelines, allele functions, for precision medicine and genotype-guided — from…
Linear issue tracking integration - Create, update, and manage Linear issues and projects using the GraphQL API
Trim multiple sequence alignments using ClipKIT, trimAl, BMGE, Divvier, or HMMcleaner with mode selection guidance per downstream goal.
Joint genotype calling across multiple samples using GATK CombineGVCFs and GenotypeGVCFs. Essential for cohort studies, population genetics, and leveraging VQSR.
Manage Git workflows including commits, branches, merges, and collaboration. Use when working with Git repositories, creating commits, managing branches, or resolving conflicts.
When the user wants to create, optimize, or audit affiliate program page content. Also use when the user mentions "affiliate program," "affiliate page," "partner program,"…
Review frontend code for accessibility, UI security, missing states, and UX regressions. Use when asked to review React components, run a pre-merge frontend review, or check a11y…
Generate AI music on RunComfy via the `runcomfy` CLI. Routes to ElevenLabs Music (premium vocal, $0.0083/s) or ACE Step / 1.5 (open-weights, $0.0002–0.0003/s, multilingual), plus…
PyTorch-native graph neural networks for molecules and proteins. Use when building custom GNN architectures for drug discovery, protein modeling, or knowledge graph reaso — from…