Construct and analyze compound-target-disease networks for drug repurposing, polypharmacology discovery, and systems pharmacology.
Create and edit Obsidian Bases (.base files) with views, filters, formulas, and summaries. Use when working with .base files, creating database-like views of notes, or wh — from…
Visualises RNA-modification data with transcript-feature metagene plots (Guitar GuitarPlot with 5'UTR / CDS / 3'UTR scaling; MetaPlotR; deepTools `computeMatrix scale-regions`),…
PyTorch-native graph neural networks for molecules and proteins. Use when building custom GNN architectures for drug discovery, protein modeling, or knowledge graph reaso — from…
Semantic search across UK Biobank's 12,000+ data fields and publications — find the right variables for your research question.
Multi-channel demand generation, paid media optimization, SEO strategy, and partnership programs for Series A+ startups.
Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cu — from…
Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Li & Hart 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and…
Profiles a genome from raw reads BEFORE assembly with a k-mer spectrum (KMC or Jellyfish histogram), then models it with GenomeScope2 to estimate genome size, heterozygosity,…
Deep learning-based variant calling from long reads using Clair3 for SNPs and small indels. Use when calling germline variants from ONT or PacBio alignments, particularly — from…
Structured manuscript/grant review with checklist-based evaluation. Use when writing formal peer reviews with specific criteria methodology assessment, statistical validi — from…
Retrieves biological sequences (DNA, RNA, protein) from NCBI and ENA with gene disambiguation, accession type handling, and comprehensive sequence profiles.
Migrate from AngularJS to Angular using hybrid mode, incremental component rewriting, and dependency injection updates.
Specialized lipidomics analysis for lipid identification, quantification, and pathway interpretation.
Model product UI actions from user intent questions after a meaningful outcome, completion, created resource, imported data, uploaded file, synced integration, report, deployment,…
Frontend development guidelines for Next.js + React 19 + shadcn/ui applications. Modern patterns including App Router, Server Components, Client Components, Server Action — from…
Map identified threats to appropriate security controls and mitigations. Use when prioritizing security investments, creating remediation plans, or validating control eff — from…
When the user wants to add or optimize Twitter Card metadata for X (Twitter) link previews. Also use when the user mentions "Twitter Card," "twitter:card," "twitter:image,"…
Lip-sync a face to a specific audio track on RunComfy via the `runcomfy` CLI. Routes across ByteDance OmniHuman (audio-driven full-body avatar from a portrait + audio), Sync Labs…
Quality control and exploration of RNA-seq count matrices before differential expression. Check for outliers, batch effects, and sample relationships.
Identify and prioritize causal variants at GWAS loci using statistical fine-mapping and locus-to-gene predictions.
Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance.
Configure mutual TLS (mTLS) for zero-trust service-to-service communication. Use when implementing zero-trust networking, certificate management, or securing internal ser — from…
Knowledge and utilities for creating animated GIFs optimized for Slack. Provides constraints, validation tools, and animation concepts.
Frontend development guidelines for React/TypeScript applications. Modern patterns including Suspense, lazy loading, useSuspenseQuery, file organization with features dir — from…
Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd,…
Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for…
Merge, concatenate, sort, intersect, and subset VCF files using bcftools. Use when combining variant files, comparing call sets, or restructuring VCF data. — from bg-szy/TOP-SKILLS
Generate AI videos on RunComfy via the `runcomfy` CLI — a smart router across the full video-model catalog: HappyHorse 1.0 (Arena #1, native in-pass audio), Wan-AI Wan 2-7 (open…
Orchestrates an end-to-end CRISPR editing experiment design from target gene to delivery-ready, validatable constructs.
Analyzes time-to-event data using Kaplan-Meier curves, log-rank tests, and Cox proportional hazards regression with lifelines.
Power BI development with PBIP format — TMDL models, Power Query (M), DAX measures, star schema design, report authoring, publishing to Power BI Service, scheduled refresh, and…
Extract, filter, annotate, and export differential expression results from DESeq2 or edgeR. Use for identifying significant genes, applying multiple testing corrections — from…
Performs set operations on genomic intervals - intersect (-wa/-wb/-wo/-wao/-loj/-c/-v/-u), subtract (-A), merge (-d, -c/-o), complement, cluster, multiinter, unionbedg, map, and…
Distributed computing for larger-than-RAM pandas/NumPy workflows. Use when you need to scale existing pandas/NumPy code beyond memory or across clusters.
Use when creating new skills, editing existing skills, or verifying skills work before deployment — from bg-szy/TOP-SKILLS
When the user wants to add or optimize Open Graph metadata for social sharing. Also use when the user mentions "Open Graph," "og:tags," "og:title," "og:image," "og:description,"…
Firecrawl handles all web operations with superior accuracy, speed, and LLM-optimized output. Replaces all built-in and third-party web, browsing, scraping, research, new — from…
Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta…
Merge, concatenate, sort, intersect, and subset VCF files using bcftools. Use when combining variant files, comparing call sets, or restructuring VCF data. — from bg-szy/TOP-SKILLS
Design microservices architectures with service boundaries, event-driven communication, and resilience patterns.
Identify tumor neoantigens from somatic mutations using pVACtools for personalized cancer immunotherapy.
Zabbix monitoring system automation via API and Python. Use when: (1) Managing hosts, templates, items, triggers, or host groups, (2) Automating monitoring configuration, (3)…
Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 with `bam_ip` + `bam_input` (control arm) and `bam_treated_ip` +…
Detect transcription factor binding sites through footprinting analysis in ATAC-seq data using TOBIAS.
Validate Ribo-seq data quality by checking 3-nucleotide periodicity and calculating P-site offsets. Use when assessing library quality or determining read offsets for dow — from…
Implement GitOps workflows with ArgoCD and Flux for automated, declarative Kubernetes deployments with continuous reconciliation.
Comprehensive guide for Dependency-Track - Software Composition Analysis (SCA) and SBOM management platform.
Generate commit message, PR title, and PR body for a pull request. Use when the user wants to create a PR, generate PR content, prepare a pull request, or fill a PR template from…
Validate, gap-fill, and curate genome-scale metabolic models using memote for quality scores and COBRApy for manual curation.
Web search and content extraction with Tavily and Exa via inference.sh CLI. Apps: Tavily Search, Tavily Extract, Exa Search, Exa Answer, Exa Extract.
Quality control for flow, spectral, and mass cytometry - time-based anomaly cleaning (flowAI, flowCut, PeacoQC, flowClean), margin/boundary event removal, signal-drift detection,…
Build interactive HTML/web visualizations with plotly (Python/R), bokeh (Python), and gganimate/plotly frames for animation, with awareness of current Kaleido static-export model…
Work with FASTQ quality scores using Biopython. Use when analyzing read quality, filtering by quality, trimming low-quality bases, or generating quality reports.
Generate images with Flux 2 Klein (Black Forest Labs' distilled fast variant of Flux 2) on RunComfy — bundled with the model's documented prompting patterns so the skill — from…
Browser automation for AI agents via inference.sh. Navigate web pages, interact with elements using @e refs, take screenshots, record video.
When the user wants to design, optimize, or audit carousel/slider layouts for content display. Also use when the user mentions "carousel," "slider," "carousel layout,"…
Render videos from React/Remotion component code via inference.sh. Pass TSX code, get MP4. Supports all Remotion APIs: useCurrentFrame, useVideoConfig, spring, interpolat — from…
Load, convert, and manipulate Hi-C contact matrices using cooler format. Read .cool/.mcool files, convert from .hic format, access matrix data, and export to different fo — from…
Master creating MCP tools with type-safe parameters, automatic schema generation, and best practices — from bg-szy/TOP-SKILLS