Comprehensive guide for building Model Context Protocol (MCP) servers with support for tools, resources, prompts, and authentication.
Drop a folder of vendor quotes, proposals, and SOWs on Cowork -- normalizes them into one comparison matrix, computes true total cost of ownership, surfaces the terms each vendor…
Orchestrate multi-agent swarms with agentic-flow for parallel task execution, dynamic topology, and intelligent coordination.
Search Engine Optimization specialist for content strategy, technical SEO, keyword research, and ranking improvements.
Knowledge and utilities for creating animated GIFs optimized for Slack. Provides constraints, validation tools, and animation concepts.
Build NEAR Protocol dApps. Use for: (1) creating new NEAR dApps with `create-near-app` (Vite+React, Next.js), (2) adding NEAR wallet connection to existing apps with `@ho — from…
Reads, writes, and converts molecular file formats (SMILES, InChI, SDF V2000/V3000, MOL2, PDB, MMTF) using RDKit and Open Babel with rigorous handling of aromaticity perception,…
Review homework notebooks for completeness, reproducibility, safe execution, and academic-integrity boundaries.
Detect structural variants from long-read alignments using Sniffles, cuteSV, and SVIM. Use when detecting deletions, insertions, inversions, translocations, or complex re — from…
Detect horizontal gene transfer (HGT / LGT) using compositional methods (GC%, codon usage, tetranucleotide z-scores via SIGI-HMM, AlienHunter, IslandViewer 4, IslandPath- — from…
Search ClinicalTrials.gov with natural language queries. Find clinical trials, enrollment, and outcomes using Valyu semantic search.
Guide for creating MCP (Model Context Protocol) servers. Use this when building integrations with external services, creating new MCP servers, or connecting Claude to APIs.
Production-ready reinforcement learning algorithms (PPO, SAC, DQN, TD3, DDPG, A2C) with scikit-learn-like API.
Comprehensive variant filtering including GATK VQSR, hard filters, bcftools expressions, and quality metric interpretation for SNPs and indels.
QIIME2 command-line workflow for 16S/ITS amplicon analysis. Alternative to DADA2/phyloseq R workflow with built-in provenance tracking.
Master monorepo management with Turborepo, Nx, and pnpm workspaces to build efficient, scalable multi-package repositories with optimized builds and dependency management.
Spawn a new terminal window to run CLI commands (ffmpeg, curl, python, etc.). Use for non-AI command execution. — from bg-szy/TOP-SKILLS
When the user wants to create, optimize, or audit blog index or listing page structure (not a single post).
Delegate routine work to subagents — boilerplate generation, data transformation, file analysis, documentation drafting.
Gene Set Enrichment Analysis using clusterProfiler gseGO and gseKEGG. Use when analyzing ranked gene lists to find coordinated expression changes in gene sets without arb — from…
When the user wants to create, optimize, or audit features page content. Also use when the user mentions "features page," "product features," "capabilities," "what it does,"…
Visualize metagenomic profiles using R (phyloseq, microbiome) and Python (matplotlib, seaborn). Create stacked bar plots, heatmaps, PCA plots, and diversity analyses.
Analyzes spatial proteomics data from CODEX, IMC, and MIBI platforms including cell segmentation and protein colocalization.
Master smart contract security best practices to prevent common vulnerabilities and implement secure Solidity patterns.
When the user wants to create, optimize, or validate URL slugs for content pages. Also use when the user mentions "URL slug," "URL path," "blog URL," "article URL," "short URL,"…
Statistical models library for Python. Use when you need specific model classes (OLS, GLM, mixed models, ARIMA) with detailed diagnostics, residuals, and inference.
Review UI code for Web Interface Guidelines compliance. Use when asked to "review my UI", "check accessibility", "audit design", "review UX", or "check my site against be — from…
Create commit messages following Sentry conventions. Use when committing code changes, writing commit messages, or formatting git history.
End-to-end single-cell RNA-seq workflow from 10X Genomics data to annotated cell types. Covers QC, normalization, clustering, marker detection, and cell type annotation — from…
Perform multiple sequence alignment using MAFFT, MUSCLE5, ClustalOmega, or T-Coffee. Guides tool and algorithm selection based on dataset size, sequence divergence, and downstream…
Generate images with Google Nano Banana 2 (Gemini-family flash-tier text-to-image) on RunComfy — bundled with the model's documented prompting patterns so the skill gets — from…
Use when about to claim work is complete, fixed, or passing, before committing or creating PRs - requires running verification commands and confirming output before makin — from…
Generate variant statistics, sample concordance, and quality metrics using bcftools stats and gtcheck.
Phases small variants, SVs, and methylation from Oxford Nanopore and PacBio long reads (read-backed/physical phasing) with WhatsHap, LongPhase, or HiPhase, and haplotags the BAM…
Use when you have a spec or requirements for a multi-step task, before touching code — from bg-szy/TOP-SKILLS
Comprehensive antibody engineering and optimization for therapeutic development. Covers humanization, affinity maturation, developability assessment, and immunogenicity…
Use when the user asks for Internal Change Adoption Course from supplied source materials. Trigger language: internal change adoption; organizational change; internal software…
Frontend development guidelines for React/TypeScript applications. Modern patterns including Suspense, lazy loading, useSuspenseQuery, file organization with features dir — from…
Tracks ctDNA dynamics over time for treatment response monitoring using serial liquid biopsy samples.
Use this umbrella skill when the request spans multiple AltLLM Portal CLI domains, or when you need to navigate the local altllm CLI in this repository across auth, API k — from…
Guides and best practices for working with Neon Serverless Postgres. Covers getting started, local development with Neon, choosing a connection method, Neon features, aut — from…
Use when facing 2+ independent tasks that can be worked on without shared state or sequential dependencies — from bg-szy/TOP-SKILLS
Extract, process, and deduplicate reads using Unique Molecular Identifiers (UMIs) with umi_tools. Use when library prep includes UMIs and accurate molecule counting is ne — from…
Access protein metadata, function, taxonomy, and sequences across UniProtKB, UniParc, and UniRef. Use when searching for proteins, mapping identifiers, or retrieving functional…
Align preprocessed CLIP-seq reads (eCLIP, iCLIP, iCLIP2, PAR-CLIP) to genome with STAR or bowtie2 using crosslink-preserving parameters, choosing between unique-mapper-only and…
Implement efficient similarity search with vector databases. Use when building semantic search, implementing nearest neighbor queries, or optimizing retrieval performance — from…
Guide for breaking changes into logical, atomic commits using interactive staging. Use when committing changes that span multiple concerns, when needing to stage parts of files…
Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cu — from…
Detects spatially variable genes, spatial autocorrelation, and cell-type colocalization for spatial transcriptomics using Squidpy with PySAL/esda for local statistics.
Still-to-video conversion guide: model selection, motion prompting, and camera movement. Covers Wan 2.5 i2v, Seedance, Fabric, Grok Video with when to use each.
Detect transcription factor binding sites through footprinting analysis in ATAC-seq data using TOBIAS.
Analyze population structure using PCA and admixture analysis with PLINK and ADMIXTURE. Identify population clusters, assess ancestry proportions, visualize genetic struc — from…
Picks random winners from lists, spreadsheets, or Google Sheets for giveaways, raffles, and contests. Ensures fair, unbiased selection with transparency. — from bg-szy/TOP-SKILLS
Applies Anthropic's official brand colors and typography to any sort of artifact that may benefit from having Anthropic's look-and-feel.
Master guide for using Claude Code effectively. Includes configuration templates, prompting strategies "Thinking" keywords, debugging techniques, and best practices for i — from…
Filter alignments by flags, mapping quality, and regions using samtools view and pysam. Use when extracting specific reads, removing low-quality alignments, or subsetting — from…
Use when Codex, Hermes, OpenClaw, Claude Code, Cowork, or another AI agent needs to plan, review, implement, audit, or improve email work focused on campaign briefs, audi — from…
Strategic clinical trial design feasibility assessment using ToolUniverse. Evaluates patient population sizing, biomarker prevalence, endpoint selection, comparator analysis,…
Git operations, shell scripting, CI/CD pipelines, and terminal automation. Use for conventional commits, PowerShell/Bash scripting, configuring GitHub Actions, or automating…
Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC…