Visualize Hi-C contact matrices, TADs, loops, and genomic features using matplotlib, cooltools, and HiCExplorer.
When the user wants to define, audit, or apply visual identity (typography, colors, spacing, design tokens, frontend aesthetics).
Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance.
Authorization system with role-based access control. Must-have for all apps that manage personal or access-restricted data.
Trim PCR primers from aligned reads in amplicon-panel BAMs using samtools ampliconclip. Use when processing SARS-CoV-2 ARTIC, hereditary cancer panels, ctDNA hot-spot panels, or…
Core component library and design system patterns. Use when building UI, using design tokens, or working with the component library. — from bg-szy/TOP-SKILLS
Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui).
Process multiple sequence files in batch using Biopython. Use when working with many files, merging/splitting sequences, or automating file operations across directories.
Enforce RED-GREEN-REFACTOR cycle. Use when implementing features, fixing bugs, or writing any production code.
Differential gene expression analysis (Python DESeq2). Identify DE genes from bulk RNA-seq counts, Wald tests, FDR correction, volcano/MA plots, for RNA-seq analysis.
Run the Gemini file processor on any folder — extracts content from PDF, PPTX, XLSX, DOCX, CSV, JSON, and any text format, then generates Obsidian-ready summaries.
Deep learning-based variant calling with Google DeepVariant. Provides high accuracy for germline SNPs and indels from Illumina, PacBio, and ONT data.
Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA…
YouTube thumbnail design with specific dimensions, contrast rules, and mobile preview optimization. Covers safe zones, text placement, face expression psychology, and A/B — from…
Use when creating new skills, editing existing skills, or verifying skills work before deployment — from bg-szy/TOP-SKILLS
XCMS3 workflow for LC-MS/MS metabolomics preprocessing. Covers peak detection, retention time alignment, correspondence (grouping), and gap filling.
Use when doing ANY task involving Supabase. Triggers: Supabase products (Database, Auth, Edge Functions, Realtime, Storage, Vectors, Cron, Queues); client libraries and S — from…
Filter reads by quality scores, length, and N content using Trimmomatic and fastp. Apply sliding window trimming, remove low-quality bases from read ends, and discard rea — from…
Master Bash Automated Testing System (Bats) for comprehensive shell script testing. Use when writing tests for shell scripts, CI/CD pipelines, or requiring test-driven de — from…
End-to-end proteomics workflow from MaxQuant output to differential protein abundance. Orchestrates data import, normalization, imputation, and statistical testing with l — from…
Read a liarjs fingerprint report and attribute each failing check to the component that produced it - what the check id measures, whether the signal comes from the launch…
Select restriction enzymes by criteria using Biopython Bio.Restriction. Find enzymes that cut once, don't cut, produce specific overhangs, are commercially available, or — from…
Analyze competitor website structures, messaging patterns, and unique features. Use when researching competition, identifying gaps, or informing content strategy.
When the user wants to find information sources for content ideation, competitor monitoring, or industry tracking.
Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content.
Taxonomic classification of ASVs using reference databases like SILVA, GTDB, or UNITE. Covers naive Bayes classifiers (DADA2, IDTAXA) and exact matching approaches.
Comprehensive document creation, editing, and analysis with support for tracked changes, comments, formatting preservation, and text extraction.
When the user wants to create, optimize, or audit an affiliate, sponsor, or paid partnership disclosure page.
Inspect CSV datasets for schema, quality, modeling readiness, and feature analysis.
Create distinctive, production-grade frontend interfaces with intentional aesthetics, high craft, and non-generic visual identity.
Discovers available Azure OpenAI model capacity across regions and projects. Analyzes quota limits, compares availability, and recommends optimal deployment locations bas — from…
Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools.
Browser automation for AI agents via inference.sh. Navigate web pages, interact with elements using @e refs, take screenshots, record video.
Annotate ChIP-seq peaks to genomic features and genes using ChIPseeker. Assign peaks to promoters, exons, introns, and intergenic regions.
Generate AI videos with Google Veo, Seedance, Wan, Grok and 40+ models via inference.sh CLI. Models: Veo 3.1, Veo 3, Seedance 1.5 Pro, Wan 2.5, Grok Imagine Video, OmniHu — from…
Identifies super-enhancers from H3K27ac, MED1, or BRD4 ChIP-seq using ROSE, ROSE2, LILY, HOMER -style super, and ENCODE dELS cross-referencing.
Create a new git escrow bounty for a test suite. Use when the user wants to submit a challenge with escrowed token rewards for passing a failing test suite.
Create opinionated premium DESIGN.md guidance for Stitch, emphasizing calibrated typography, restrained color, layout discipline, motion, and anti-generic UI rules.
Quality control and assessment for proteomics data. Use when evaluating proteomics data quality before downstream analysis.
Query the ClinPGx API for pharmacogenomic gene-drug data, clinical annotations, CPIC guidelines, and FDA drug labels
Generate and publish a project status artifact — an opinionated, tabbed status page for a project too big for one update (overview & success criteria, the workstream sequence,…
Create distributable Python packages with proper project structure, setup.py/pyproject.toml, and publishing to PyPI.
Generate or edit images using AI models (FLUX, Gemini). Use for general-purpose image generation including photos, illustrations, artwork, visual assets, concept art, and any…
Detect antimicrobial resistance genes using AMRFinderPlus, ResFinder, and CARD. Screen isolates and metagenomes for resistance determinants.
Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library fi — from…
Estimate bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate,…
Use when about to claim work is complete, fixed, or passing, before committing or creating PRs - requires running verification commands and confirming output before makin — from…
Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta…
AI-assisted pair programming with multiple modes (driver/navigator/switch), real-time verification, quality monitoring, and comprehensive testing.
Browser automation for AI agents via inference.sh. Navigate web pages, interact with elements using @e refs, take screenshots, record video.
Build read models and projections from event streams. Use when implementing CQRS read sides, building materialized views, or optimizing query performance in event-sourced — from…
Identify domains, families, and sites in proteins; find all proteins in a family or sharing a domain; explore species distribution for a domain; annotate genomes with protein…
Interact with Alkahest escrow contracts as a buyer, seller, or oracle using the CLI — from bg-szy/TOP-SKILLS
Jest testing patterns, factory functions, mocking strategies, and TDD workflow. Use when writing unit tests, creating test factories, or following TDD red-green-refactor — from…
Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit…
Guide for creating MCP (Model Context Protocol) servers. Use this when building integrations with external services, creating new MCP servers, or connecting Claude to APIs.
Adapt an English-language SaaS product for a China market launch with evidence-safe positioning, Chinese landing-page copy, channel-fit recommendations, WeChat content, optional…
Differential binding analysis using DiffBind. Compare ChIP-seq peaks between conditions with statistical rigor. Requires replicate samples.
When the user wants to design, optimize, or audit carousel/slider layouts for content display. Also use when the user mentions "carousel," "slider," "carousel layout,"…
Implement modern responsive layouts using container queries, fluid typography, CSS Grid, and mobile-first breakpoint strategies.