You MUST use this before any creative work - creating features, building components, adding functionality, or modifying behavior.
Analyze Perturb-seq and CROP-seq CRISPR screening data integrated with scRNA-seq. Use when identifying gene function through pooled genetic perturbations in single cells.
Compute spatial statistics for spatial transcriptomics data using Squidpy. Calculate Moran's I, Geary's C, spatial autocorrelation, co-occurrence analysis, and neighborho — from…
Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent…
End-to-end spatial transcriptomics workflow for Visium/Xenium data. Covers data loading, preprocessing, spatial analysis, domain detection, and visualization with Squidpy — from…
Implement comprehensive testing strategies with pytest, fixtures, mocking, and test-driven development.
Generate consensus FASTA sequences by applying VCF variants to a reference using bcftools consensus. Use when creating sample-specific reference sequences or reconstructi — from…
Guide Claude through omicverse's bulk RNA-seq DEG pipeline, from gene ID mapping and DESeq2 normalization to statistical testing, visualization, and pathway enrichment.
Implement comprehensive testing strategies with pytest, fixtures, mocking, and test-driven development.
Create and optimize popups, modals, overlays, slide-ins, and banners to increase conversions without harming user experience or brand trust. — from bg-szy/TOP-SKILLS
T-SQL, stored procedures, and MS SQL Server DBA practices. Use when writing SQL queries, designing schemas, tuning SQL Server performance, managing backups, configuring security,…
Build volcano and MA plots from differential-expression / association results with LFC shrinkage, FDR-adjusted thresholds, sensible label placement, and axis-truncation…
Similarity Network Fusion (SNF) for patient stratification using multi-omics data. Integrates multiple data types into a unified patient similarity network.
Set up Prometheus for comprehensive metric collection, storage, and monitoring of infrastructure and applications.
Run a pre-deploy browser audit of a live, preview, or local web page for accessibility, SEO, Lighthouse quality, and critical UX issues.
Master TypeScript's advanced type system including generics, conditional types, mapped types, template literals, and utility types for building type-safe applications.
End-to-end imaging mass cytometry workflow from raw acquisitions to spatial cell analysis. Orchestrates image preprocessing, segmentation, phenotyping, and spatial statis — from…
Use when setting up environment configuration, loading .env files, or managing application settings across environments.
Perform statistical modeling and regression analysis on biomedical datasets. Supports linear regression, logistic regression (binary/ordinal/multinomial), mixed-effects models,…
Discover, validate, and invoke .agent.md custom agents. Use when finding agent files in the local Claude or VS Code Insiders directories, checking frontmatter, verifying…
Annotate CNVs with genes, pathways, and clinical significance. Use when interpreting CNV calls or identifying affected genes from copy number analysis.
Detect distant homologs using profile and structure-aware methods that go beyond standard BLAST. Use when sequence identity falls into the twilight zone (<35% pairwise), when…
Create pull requests following Sentry conventions. Use when opening PRs, writing PR descriptions, or preparing changes for review.
World-class computer vision skill for image/video processing, object detection, segmentation, and visual AI systems.
Git worktree workflow, conventional commits, commit trailers, and PR guidelines. Activated during git operations and commits.
When the user wants to create, optimize, or audit a showcase or gallery page for user-generated content.
Implements authentication and payment features using Clerk, Supabase Auth, or Stripe. Use when user mentions ログイン, 認証, auth, authentication, Clerk, Supabase, 決済, payment, Stripe,…
Detect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter.
Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui).
Prepare for US medical licensing exams with progress tracking, weak area analysis, question bank management, and residency match planning.
Generate cinematic short-form video with ByteDance Seedance 2.0 Pro on RunComfy. Documents Seedance 2.0 Pro's strengths (multi-modal references — up to 9 images, 3 videos — from…
Search global patents with natural language queries. Prior art, patent landscapes, and innovation tracking via Valyu.
When the user wants to improve crawlability, fix orphan pages, or optimize site structure for search engines.
Create pull requests following Sentry conventions. Use when opening PRs, writing PR descriptions, or preparing changes for review.
Load spatial transcriptomics data from Visium, Xenium, MERFISH, Slide-seq, and other platforms using Squidpy and SpatialData.
Modify protein structures using Biopython Bio.PDB. Use when transforming coordinates, removing atoms or residues, adding new entities, modifying B-factors and occupancies — from…
Search, browse, and install animated React components from ReactBits.dev (135+ components). Use when the user wants to add UI effects, animations, backgrounds, or interactive…
Improves the quality of images, especially screenshots, by enhancing resolution, sharpness, and clarity.
Design multi-cloud architectures using a decision framework to select and integrate services across AWS, Azure, and GCP.
Senior QMS Audit Expert for internal and external quality management system auditing. Provides ISO 13485 audit expertise, audit program management, nonconformity identifi — from…
Use when writing prose humans will read—documentation, commit messages, error messages, explanations, reports, or UI text.
Analyze protein-protein interaction networks using STRING, BioGRID, and SASBDB databases. Maps protein identifiers, retrieves interaction networks with confidence scores, performs…
Delegate routine work to subagents — boilerplate generation, data transformation, file analysis, documentation drafting.
Interact with the Labstep electronic lab notebook API using labstepPy. Query experiments, protocols, resources, inventory, and other lab entities.
Build reusable Terraform modules for AWS, Azure, and GCP infrastructure following infrastructure-as-code best practices.
An example skill demonstrating the basic structure. Use when user asks about examples or templates.
Bisulfite sequencing read alignment using Bismark with bowtie2/hisat2. Handles genome preparation and produces BAM files with methylation information.
Queries gnomAD v4 (807k samples), v3, v2.1.1, and constraint metrics with grpmax FAF95, bottleneck-group exclusion, LOEUF interpretation, SV/CNV/mtDNA catalogs, and Whiffin…
Intelligently organizes your files and folders across your computer by understanding context, finding duplicates, suggesting better structures, and automating cleanup tas — from…
Azure network planning — CIDR calculation, subnet allocation, VNet sizing, IP address planning, snet layout, network capacity, Azure networking, hub-spoke topology.
Search DrugBank comprehensive drug database with natural language queries. Drug mechanisms, interactions, and safety data powered by Valyu.
Identify drug repurposing candidates using ToolUniverse for target-based, compound-based, and disease-driven strategies.
AI voice generation, text-to-speech, and voice synthesis via inference.sh CLI. Models: Kokoro TTS, DIA, Chatterbox, Higgs, VibeVoice for natural speech.
Master the uv package manager for fast Python dependency management, virtual environments, and modern Python project workflows.
Compute evolutionary distances and build phylogenetic trees using Biopython Bio.Phylo.TreeConstruction.
Creates, edits, and manages Obsidian vault content including notes, templates, daily notes, and dataview queries.
Generate concise (3-4 page), focused medical treatment plans in LaTeX/PDF format for all clinical specialties.
Assesses the quality and completeness of a genome annotation with BUSCO (conserved single-copy ortholog recovery), OMArk (proteome completeness, consistency, and contamination),…
Enforce TypeScript strict mode and type safety. Use when setting up projects, reviewing code, or when type errors are ignored.
根据真实代码仓库、官网页面、运行界面、模块范围和目标软著数量，分析软件著作权（软著）申报方向，拆分可申报主题，检查 Logo、版权、备案、截图和源码等材料约束，生成 3w-4w 字正文、局部代码片段、源码原文、网页截图证据和 .docx 文档。Use when Claude needs to prepare or split legitimate…