Build publication-quality figures with matplotlib using the object-oriented Figure/Axes API, constrained_layout, rcParams customization, TrueType (Type-42) font embedding for…
Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models…
Detect A/B compartments from Hi-C data using cooltools and eigenvector decomposition. Identify active (A) and inactive (B) chromatin compartments from contact matrices.
Browser automation for AI agents via inference.sh. Navigate web pages, interact with elements using @e refs, take screenshots, record video.
Find marker genes and annotate cell types in single-cell RNA-seq using Seurat (R) and Scanpy (Python).
Generate AI videos with Google Veo, Seedance 2.0, HappyHorse, Wan, Grok and 40+ models via inference.sh CLI.
UX research and design toolkit for Senior UX Designer/Researcher including data-driven persona generation, journey mapping, usability testing frameworks, and research syn — from…
Statistical models library for Python. Use when you need specific model classes (OLS, GLM, mixed models, ARIMA) with detailed diagnostics, residuals, and inference.
Comprehensive software architecture skill for designing scalable, maintainable systems using ReactJS, NextJS, NodeJS, Express, React Native, Swift, Kotlin, Flutter, Postg — from…
Extend or continue an existing video clip on RunComfy via the `runcomfy` CLI. Routes to Google Veo 3-1's `extend-video` and `fast/extend-video` endpoints — pick the sourc — from…
Detect horizontal gene transfer (HGT / LGT) using compositional methods (GC%, codon usage, tetranucleotide z-scores via SIGI-HMM, AlienHunter, IslandViewer 4, IslandPath- — from…
Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data bo — from…
Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution…
Automate Twitter/X with posting, engagement, and user management via inference.sh CLI. Apps: x/post-tweet, x/post-create (with media), x/post-like, x/post-retweet, x/dm-s — from…
Modern shell prompt configuration with Powerlevel10k and Zsh Vi Mode. Use when configuring shell prompts, setting up vi/vim keybindings in zsh, customizing cursor styles per mode,…
Use when the user asks for Community Onboarding from supplied source materials. Trigger language: community onboarding; member onboarding; paid community start here.
Query the Genome Aggregation Database (gnomAD). Use when determining the rarity or allele frequency of specific genetic variants, retrieving gene constraint metrics (pLI, LOEUF)…
Generate commit message, PR title, and PR body for a pull request. Use when the user wants to create a PR, generate PR content, prepare a pull request, or fill a PR template from…
Computes DNA methylation age (DNAm age) and pace of aging by applying frozen elastic-net epigenetic clocks to a clean beta matrix with methylclock, dnaMethyAge, or methyl — from…
Performs subgroup and heterogeneous treatment effect (HTE) analyses for clinical trials. Covers Mantel-Haenszel pooling, Breslow-Day, interaction tests in regression, RER — from…
Guide for implementing obsidian.nvim - a Neovim plugin for Obsidian vault management. Use when configuring, troubleshooting, or extending obsidian.nvim features including…
Analyze metabolomics data including metabolite identification, quantification, pathway analysis, and metabolic flux.
Verify that browser profiles are actually isolated from one another instead of assuming it - confirm each profile's timezone agrees with its own exit IP, that WebRTC exposes only…
Render videos from React/Remotion component code via inference.sh. Pass TSX code, get MP4. Supports all Remotion APIs: useCurrentFrame, useVideoConfig, spring, interpolat — from…
Identify differentially accessible chromatin regions across conditions using DiffBind, csaw, DESeq2, or edgeR.
Quality control and assessment for proteomics data. Use when evaluating proteomics data quality before downstream analysis.
Quality control for pooled CRISPR screens. Covers library representation, read distribution, replicate correlation, and essential gene recovery.
Reads, inspects, and writes Flow Cytometry Standard (FCS) files from conventional, spectral, and mass cytometry (CyTOF), and parses FlowJo/Cytobank/Diva workspaces.
Identify spatial domains and tissue regions in spatial transcriptomics data using Squidpy and Scanpy.
Estimate species trees using coalescent methods including ASTRAL-III, wASTRAL, ASTRAL-Pro, SVDQuartets, and BPP.
Execute implementation plans with batch processing and review checkpoints. Use when given a plan document.
Detects and removes contamination in genome assemblies via two disjoint workflows - foreign-sequence screening of a single-organism (eukaryote/isolate) assembly with NCBI FCS-GX…
Use when designing, architecting, or planning a new system from requirements or ideas - transforms concepts into navigable design catalog using EventStorming methodology, Mermaid…
Identify and prioritize causal variants at GWAS loci using statistical fine-mapping and locus-to-gene predictions.
Analyze multi-modal single-cell data (CITE-seq, Multiome, spatial). Use when working with data that measures multiple modalities per cell like RNA + protein or RNA + ATAC — from…
Visualize ChIP-seq data using deepTools, Gviz, and ChIPseeker. Create heatmaps, profile plots, and genome browser tracks.
Comprehensive spreadsheet creation, editing, and analysis with support for formulas, formatting, data analysis, and visualization.
Use when preparing photos or images for a news wire, publication, photo CMS, or archive — embedding caption, byline, credit, alt text, keywords, copyright or Creative Commons…
Remove batch effects from RNA-seq data using ComBat, ComBat-Seq, limma removeBatchEffect, and SVA for unknown batch variables.
Design and implement event stores for event-sourced systems. Use when building event sourcing infrastructure, choosing event store technologies, or implementing event per — from…
Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF.
GitHub Pull Request作成スキル - 変更内容の自動サマリー、PR説明文生成、GitHub PRの作成を行います。git diffでの変更分析、コミットメッセージ取得、変更ファイル分類を行い、高品質なPR説明文を自動生成します。qa-check実行済みであることを前提とし、リモートへのプッシュとgh CLIによるPR作成を実行します。
Use when the user asks for Sales Enablement Training from supplied source materials. Trigger language: sales enablement training; sales readiness; go-to-market training; product…
Verification discipline for completion claims. Use when about to assert success, claim a fix is complete, report tests passing, or before commits and PRs.
When the user wants to plan cold start, get first users, or launch a new product with zero traction. Also use when the user mentions "cold start," "cold start problem," "first…
When the user wants to add, optimize, or audit a top announcement bar or sticky banner. Also use when the user mentions "announcement bar," "top banner," "sticky bar," "promo…
Access NCBI GEO for gene expression/genomics data. Search/download microarray and RNA-seq datasets (GSE, GSM, GPL), retrieve SOFT/Matrix files, for transcriptomics and ex — from…
Call structural variants (SVs) from short-read sequencing using Manta, Delly, and LUMPY. Detects deletions, insertions, inversions, duplications, and translocations that — from…
End-to-end single-cell RNA-seq workflow from 10X Genomics data to annotated cell types. Covers QC, normalization, clustering, marker detection, and cell type annotation — from…
When the user wants to write, publish, republish, or optimize posts on Medium.com (canonical tags, distribution, Medium SEO).
Transform rough ideas into detailed designs through structured dialogue. Use before implementation to refine requirements.
Use when you have a written implementation plan to execute in a separate session with review checkpoints — from bg-szy/TOP-SKILLS
Discovers available Azure OpenAI model capacity across regions and projects. Analyzes quota limits, compares availability, and recommends optimal deployment locations bas — from…
Guide for Grafana Pyroscope continuous profiling. Use for Kubernetes Helm deployment, Go/Java/Python/.NET/Ruby/Node.js profiling, storage backends, trace-to-profile linking, and…
When the user wants open source strategy, OSS commercialization, or open source growth. Also use when the user mentions "open source strategy," "OSS strategy," "open source…
Analyzes meeting transcripts and recordings to uncover behavioral patterns, communication insights, and actionable feedback.
Use when the user asks for Customer Education from supplied source materials. Trigger language: customer education; customer training; customer academy; support deflection.
Next-generation sequencing data analysis pipelines including bulk RNA-seq, scRNA-seq preprocessing, variant calling, and quality control.
Search ClinicalTrials.gov with natural language queries. Find clinical trials, enrollment, and outcomes using Valyu semantic search.
Neuropixels neural recording analysis. Load SpikeGLX/OpenEphys data, preprocess, motion correction, Kilosort4 spike sorting, quality metrics, Allen/IBL curation, AI-assis — from…