Detect and track antimicrobial resistance genes using AMRFinderPlus and ResFinder with epidemiological context.
When the user wants to optimize meta tags other than title, description, Open Graph, or Twitter Cards.
Detects and removes contamination in genome assemblies via two disjoint workflows - foreign-sequence screening of a single-organism (eukaryote/isolate) assembly with NCBI FCS-GX…
Remove sequencing adapters from FASTQ files using Cutadapt and Trimmomatic. Supports single-end and paired-end reads, Illumina TruSeq, Nextera, and custom adapter sequenc — from…
Analyze high-resolution spatial platforms like Slide-seq, Stereo-seq, and Visium HD. Use when working with subcellular resolution or high-density spatial data.
Assesses RNA-seq data quality specifically for alternative splicing analysis. QC layers include experimental design audit (library prep, read length, depth, replicates), STAR…
Create distinctive, production-grade frontend interfaces with intentional aesthetics, high craft, and non-generic visual identity.
Lightweight WSI tile extraction and preprocessing. Use for basic slide processing tissue detection, tile extraction, stain normalization for H&E images.
Configure, adjust, debug, and verify React Flow workflow nodes. Use when working on custom node components, especially for node handles, multi-channel connections, edge…
Expert speech-language pathologist specializing in AI-powered speech therapy, phoneme analysis, articulation visualization, voice disorders, fluency intervention, and assistive…
飞书视频会议：让机器人代当前用户加入/离开正在进行的会议，并读取会议期间的实时事件（参会人加入与离开、发言、聊天、屏幕共享等）。1. 用户提供 9 位会议号、要求代为入会或离会时使用 +meeting-join / +meeting-leave——会真实产生入会/离会记录。2.
Run 150+ AI apps via inference.sh CLI - image generation, video creation, LLMs, search, 3D, Twitter automation.
DNA methylation analysis with methylKit in R. Import Bismark coverage files, filter by coverage, normalize samples, and perform statistical comparisons.
Applies Anthropic's official brand colors and typography to any sort of artifact that may benefit from having Anthropic's look-and-feel.
Understand what context is, why it matters, and the anatomy of context in agent systems
Parse and write protein structure files using Biopython Bio.PDB. Use when reading PDB, mmCIF, and MMTF files, downloading structures from RCSB PDB, or writing structures — from…
Optimize content for search engines with keyword analysis, readability scoring, meta descriptions, and competitor comparison.
Detect sample contamination and cross-species reads using FastQ Screen. Screen reads against multiple reference genomes to identify bacterial, viral, adapter, or sample s — from…
When the user wants to create, optimize, or audit the API introduction/overview page. Also use when the user mentions "API page," "API landing page," "/api page," "API overview,"…
Derive security requirements from threat models and business context. Use when translating threats into actionable requirements, creating security user stories, or buildi — from…
Infer transcription factor regulons from single-cell RNA-seq with pySCENIC by combining GRNBoost2 co-expression, cisTarget motif-enrichment pruning, and AUCell per-cell activity…
Comprehensive variant filtering including GATK VQSR, hard filters, bcftools expressions, and quality metric interpretation for SNPs and indels.
When the user wants to plan, implement, or optimize student and education discount programs. Also use when the user mentions "student discount," "education discount," "student…
Manage database schema changes with version control. Use when modifying DB schema, adding tables/columns, or setting up new projects.
Simulate a Nature-style reviewer assessment from the referee perspective rather than an author rebuttal.
Identify tumor neoantigens from somatic mutations using pVACtools for personalized cancer immunotherapy.
Conduct comprehensive literature research with target disambiguation, evidence grading, and structured theme extraction.
Calculate portfolio risk metrics including VaR, CVaR, Sharpe, Sortino, and drawdown analysis. Use when measuring portfolio risk, implementing risk limits, or building ris — from…
Browser automation for AI agents via inference.sh. Navigate web pages, interact with elements using @e refs, take screenshots, record video.
Generate text-to-video with HappyHorse 1.0 on RunComfy. Documents HappyHorse 1.0's strengths (#1 on Artificial Analysis Video Arena, native 1080p with in-pass synchronize — from…
Call structural variants (SVs) from sequencing data using Manta, Delly, GRIDSS, and LUMPY. Detects deletions, insertions, inversions, duplications, and translocations too large…
Quantifies alternative splicing as PSI (percent spliced in) from RNA-seq using rMATS-turbo (BAM-based event), SUPPA2 (TPM-based event), MAJIQ V3 (LSV-based Bayesian), leafcutter…
Use when about to claim work is complete, fixed, or passing, before committing or creating PRs - requires running verification commands and confirming output before makin — from…
When the user wants to fix indexing issues from Search Console, use noindex, or implement Google Indexing API.
Write, review, or improve SwiftUI code following best practices for state management, view composition, performance, modern APIs, Swift concurrency, and iOS 26+ Liquid Gl — from…
Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7,…
Performs molecular similarity searching using Tanimoto, Tversky, Dice, and cosine coefficients on bit/count fingerprints with explicit choice rules for symmetric vs asymm — from…
When the user wants to choose or execute third-party platform SEO (high-authority sites for rankings or backlinks).
JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens) for modeling sgRNA efficacy and gene essentiality.
Parse FCS (Flow Cytometry Standard) files v2.0-3.1. Extract events as NumPy arrays, read metadata/channels, convert to CSV/DataFrame, for flow cytometry data preprocessin — from…
Shell script static analysis and linting. USE WHEN shellcheck, lint shell, bash lint, sh lint, script analysis, shell errors, SC codes, shell best practices.
Analyze mass spectrometry proteomics data including protein quantification, differential expression, post-translational modifications (PTMs), and protein-protein interactions.
Generate AI music on RunComfy via the `runcomfy` CLI — a smart router across the music-model catalog.
Use when partner provides a complete implementation plan to execute in controlled batches with review checkpoints - loads plan, reviews critically, executes tasks in batc — from…
Bootstrap a structured research project on any topic — generate an initial items list and research-field schema from model knowledge, supplement with up-to-date web search, then…
Classify constitutional (germline) copy number variants for clinical reporting using the 2019 ACMG/ClinGen technical standards points-based framework, with ClassifyCNV an — from…
Techniques for analyzing existing codebases to reverse-engineer requirements and understand business logic.
Implement Kubernetes security policies including NetworkPolicy, PodSecurityPolicy, and RBAC for production-grade security.
View, query, and understand VCF/BCF variant files using bcftools and cyvcf2. Use when inspecting variants, extracting specific fields, or understanding VCF format structu — from…
Analyzes alternative splicing from PacBio Iso-Seq (HiFi, Kinnex/MAS-Iso-seq) and Oxford Nanopore (direct cDNA, direct RNA, R10.4.1+) long-read RNA-seq with full-isoform…
Optimize vector index performance for latency, recall, and memory. Use when tuning HNSW parameters, selecting quantization strategies, or scaling vector search infrastruc — from…
Corrects fluorophore spillover (conventional compensation) or spectral overlap (spectral unmixing) and applies variance-stabilizing transforms (logicle/biexponential, arcsinh,…
Assembles microbial-community sequencing into metagenome-assembled genomes (MAGs) with metaFlye (ONT), metaSPAdes/MEGAHIT (Illumina), and hifiasm-meta/metaMDBG (PacBio HiFi), then…
Recognize patterns of context failure: lost-in-middle, poisoning, distraction, and clash
Create portable bioinformatics pipelines with Workflow Description Language (WDL) using Cromwell or miniwdl execution engines.
Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains.
Use when reverse engineering tools are missing, not working, or need configuration. Installation guides for radare2 (r2), Ghidra, GDB, QEMU, Frida, binutils, and cross-co — from…
Reads, writes, and converts molecular file formats (SMILES, InChI, SDF V2000/V3000, MOL2, PDB, MMTF) using RDKit and Open Babel with rigorous handling of aromaticity perception,…
Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2 — from…
Quality control and normalization for metabolomics data. Covers QC-based correction, batch effect removal, and data transformation methods.