Decides whether and how to polish a draft genome assembly to raise consensus accuracy (QV) with read-type-matched tools - Racon and medaka (ONT consensus), dorado polish,…
Performs molecular similarity searches using Tanimoto coefficient on fingerprints via RDKit. Finds structurally similar compounds using ECFP or MACCS keys and clusters molecules…
Analyze PacBio Iso-Seq data for full-length isoform discovery and quantification. Use when characterizing transcript diversity or identifying novel splice variants.
Design and implement demos combining x402 HTTP payments with ERC-7710 smart contract delegations and ERC-7715 wallet permission requests for subscriptions, bounded agent — from…
Guide Claude through omicverse's bulk RNA-seq DEG pipeline, from gene ID mapping and DESeq2 normalization to statistical testing, visualization, and pathway enrichment.
Extract medical entities (symptoms, medications, lab values, diagnoses) from patient messages.
Detects somatic mutations in circulating tumor DNA using variant callers optimized for low allele fractions with UMI-based error suppression.
Create AI avatar and talking head videos via inference.sh CLI. Recommended: P-Video-Avatar (fastest, cheapest, built-in TTS). Also: OmniHuman, Fabric, PixVerse.
Guides creation of effective Agent Skills with proper structure and validation. Use when users want to create a new skill, update an existing skill, or need guidance on s — from…
Senior GDPR/DSGVO expert and internal/external auditor for data protection compliance. Provides EU GDPR and German DSGVO expertise, privacy impact assessments, data prote — from…
Generate and edit images with OpenAI GPT Image 2 (ChatGPT Images 2.0) on RunComfy. Documents GPT Image 2's strengths (embedded text, logos, multilingual typography, instr — from…
Compares how a rhythm CHANGES between conditions, genotypes, treatments, tissues, or ages (differential rhythmicity), classifying each feature as gain-of-rhythm, loss-of-rhythm,…
Extract and analyze mutational signatures from somatic variants using SigProfiler or MutationalPatterns to characterize mutagenic processes.
Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens.
Generates creative domain name ideas for your project and checks availability across multiple TLDs (.com, .io, .dev, .ai, etc.).
Detects putative ligand-binding pockets and druggable cavities de novo on an apo protein structure with fpocket, P2Rank, CASTp, and DoGSiteScorer, ranking them by…
Master Go concurrency with goroutines, channels, sync primitives, and context. Use when building concurrent Go applications, implementing worker pools, or debugging race — from…
Run 150+ AI apps via inference.sh CLI - image generation, video creation, LLMs, search, 3D, Twitter automation.
Map translation initiation sites, including non-AUG and alternative starts, from initiation-drug ribosome profiling (TI-seq).
Retrieves chemical compound information from PubChem and ChEMBL with disambiguation, cross-referencing, and quality assessment.
Use when starting any conversation - establishes how to find and use skills, requiring Skill tool invocation before ANY response including clarifying questions — from…
Run remote BLAST searches against NCBI servers using Biopython Bio.Blast.NCBIWWW. Use when identifying unknown sequences, finding homologs, picking the correct BLAST program…
Queries gnomAD v4 (807k samples), v3, v2.1.1, and constraint metrics with grpmax FAF95, bottleneck-group exclusion, LOEUF interpretation, SV/CNV/mtDNA catalogs, and Whiffin…
Chart and visualization generation for DBX Studio. Use when a user wants to visualize data — bar charts, line graphs, pie charts, scatter plots, etc. — from bg-szy/TOP-SKILLS
Perform geometric calculations on protein structures using Biopython Bio.PDB. Use when measuring distances, angles, and dihedrals, superimposing structures, calculating R — from…
Exports publication-ready figures in various formats with proper resolution, sizing, and typography. Use when preparing figures for journal submission, creating vector gr — from…
Create and use BAI/CSI indices for BAM/CRAM files using samtools and pysam. Use when enabling random access to alignment files or fetching specific genomic regions.
Interactive guided deployment flow for Azure OpenAI models with full customization control. Step-by-step selection of model version, SKU (GlobalStandard/Standard/Provisio — from…
Creates reproducible Jupyter notebooks for bioinformatics analysis with parameterization using papermill.
Analyze Perturb-seq and CROP-seq CRISPR screening data integrated with scRNA-seq. Use when identifying gene function through pooled genetic perturbations in single cells.
Bisulfite sequencing read alignment using Bismark with bowtie2/hisat2. Handles genome preparation and produces BAM files with methylation information.
Find cross-database references between NCBI databases using Biopython Bio.Entrez (ELink). Use when navigating gene to protein/structure, sequence to publication, PubMed to GEO,…
Quality control, filtering, and normalization for single-cell RNA-seq using Seurat (R) and Scanpy (Python).
Master authentication and authorization patterns including JWT, OAuth2, session management, and RBAC to build secure, scalable access control systems.
Generate cinematic short-form video with ByteDance Seedance 2.0 Pro on RunComfy. Documents Seedance 2.0 Pro's strengths (multi-modal references — up to 9 images, 3 videos — from…
Automated code review analyzing security, performance, maintainability, and test coverage. Activated during code reviews or when conducting analysis.
Enforce proper error handling patterns. Use when writing async code, API calls, or user-facing features.
Serena MCP for project memory and code navigation. Use when managing Serena memories, navigating symbols, performing intelligent refactoring, or maintaining context/continuity…
Semantic search across UK Biobank's 12,000+ data fields and publications — find the right variables for your research question.
Design LLM applications using the LangChain framework with agents, memory, and tool integration patterns.
Create scientific conference posters as native, editable .pptx files using python-pptx. Handles A0/A1 layouts, section placement, figure insertion, and academic color schemes.
Infers person-to-person transmission from pathogen genomes using outbreaker2 (Campbell 2018), TransPhylo (Didelot 2017), phybreak (Klinkenberg 2017), BadTrIP (De Maio 2018),…
Create SEO-optimized marketing content with consistent brand voice. Includes brand voice analyzer, SEO optimizer, content frameworks, and social media templates.
Runs and configures curated nf-core community Nextflow pipelines (rnaseq, sarek, atacseq, methylseq, ampliseq, taxprofiler, fetchngs) reproducibly, pinning the pipeline revision…
Visualize enrichment results using enrichplot package functions. Use when creating publication-quality figures from clusterProfiler results.
Generate AI images with FLUX, Gemini, Grok, Seedream, Reve and 50+ models via inference.sh CLI. Models: FLUX Dev LoRA, FLUX.2 Klein LoRA, Gemini 3 Pro Image, Grok Imagine — from…
Extract nucleosome positions from ATAC-seq data using NucleoATAC, ATACseqQC, and fragment analysis. Use when analyzing chromatin organization, identifying nucleosome-free regions…
XCMS3 workflow for LC-MS/MS metabolomics preprocessing. Covers peak detection, retention time alignment, correspondence (grouping), and gap filling.
When the user wants to add or optimize tab or accordion components for content organization. Also use when the user mentions "tab component," "accordion," "expandable content,"…
Estimate species trees using coalescent methods including ASTRAL-III, wASTRAL, ASTRAL-Pro, SVDQuartets, and BPP.
Quality metrics for IMC data including signal-to-noise, channel correlation, tissue integrity, and acquisition QC.
Infer developmental trajectories and pseudotime from single-cell RNA-seq data using Monocle3, Slingshot, and scVelo for RNA velocity analysis.
Quantifies alternative splicing events (PSI/percent spliced in) from RNA-seq using SUPPA2 from transcript TPM or rMATS-turbo from BAM files.
Comprehensive spreadsheet creation, editing, and analysis with support for formulas, formatting, data analysis, and visualization.
Compare Hi-C contact matrices between conditions to identify differential chromatin interactions. Compute log2 fold changes, statistical significance, and visualize diffe — from…
When the user wants to optimize the title tag, page title, or SERP title. Also use when the user mentions "title tag," "meta title," "page title," "SEO title," "SERP title,"…
Applies Anthropic's official brand colors and typography to any sort of artifact that may benefit from having Anthropic's look-and-feel.
Build production Apache Airflow DAGs with best practices for operators, sensors, testing, and deployment.
Migrate prompts and code from Claude Sonnet 4.0, Sonnet 4.5, or Opus 4.1 to Opus 4.5. Use when the user wants to update their codebase, prompts, or API calls to use Opus — from…
QIIME2 command-line workflow for 16S/ITS amplicon analysis. Alternative to DADA2/phyloseq R workflow with built-in provenance tracking.