Bootstrap a structured research project on any topic — generate an initial items list and research-field schema from model knowledge, supplement with up-to-date web search, then…
When the user wants to create competitor comparison or alternative pages for SEO and sales enablement.
Query Ensembl genome database REST API for 250+ species. Gene lookups, sequence retrieval, variant analysis, comparative genomics, orthologs, VEP predictions, for genomic — from…
Generate AI videos on RunComfy via the `runcomfy` CLI — a smart router across the full video-model catalog: HappyHorse 1.0 (Arena #1, native in-pass audio), Wan-AI Wan 2- — from…
Access and analyze AlphaFold protein structure predictions. Use when predicted structures are needed for proteins without experimental structures, or for confidence score — from…
Species abundance estimation using Bracken with Kraken2 output. Redistributes reads from higher taxonomic levels to species for more accurate estimates.
Perform V(D)J alignment and clonotype assembly from TCR-seq or BCR-seq data using MiXCR. Use when processing raw immune repertoire sequencing data to identify clonotypes — from…
XCMS3 workflow for LC-MS/MS metabolomics preprocessing. Covers peak detection, retention time alignment, correspondence (grouping), and gap filling.
Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible…
Design guide RNAs for CRISPR-Cas9/Cas12a experiments using CRISPRscan and local scoring algorithms. Score guides for on-target activity using Rule Set 2 and Azimuth model — from…
Turn a website URL, product docs, or a founder's rambling description into a tight 60-90 second explainer video built in HyperFrames -- problem/solution narrative, animated…
Guide for Grafana Pyroscope continuous profiling. Use for Kubernetes Helm deployment, Go/Java/Python/.NET/Ruby/Node.js profiling, storage backends, trace-to-profile linking, and…
Build robust backtesting systems for trading strategies with proper handling of look-ahead bias, survivorship bias, and transaction costs.
Presentation creation, editing, and analysis. When Claude needs to work with presentations (.pptx files) for: (1) Creating new presentations, (2) Modifying or editing con — from…
Use when you have a spec or requirements for a multi-step task, before touching code — from bg-szy/TOP-SKILLS
Genome-wide association studies (GWAS) with PLINK. Perform case-control and quantitative trait association testing using logistic/linear regression with covariates, gener — from…
ERC-8004 Agent identity: 注册/更新/上架/下架/搜索agent, register/update/activate/deactivate/search — User/ASP/Evaluator(买家/卖家/仲裁者); 我的agent/ASP, 找做X的ASP/agent有什么服务/endpoint怎么填/查口碑/ — from…
Normalize indel representation and split multiallelic variants using bcftools norm. Use when comparing variants from different callers or preparing VCF for downstream ana — from…
Power BI development with PBIP format — TMDL models, Power Query (M), DAX measures, star schema design, report authoring, publishing to Power BI Service, scheduled refresh, and…
Use Orca orchestration for structured multi-agent coordination: threaded messages, blocking ask/reply flows, task dispatch, worker_done/escalation waits, task DAGs, decision…
When the user wants to create, optimize, or audit a services page. Also use when the user mentions "services page," "what we offer," "service offerings," "consulting services,"…
Implement PCI DSS compliance requirements for secure handling of payment card data and payment systems.
When the user wants to analyze backlinks, audit link profile, or identify link issues. Also use when the user mentions "backlink analysis," "backlink audit," "referring domains,"…
Authentication and access control skill for Next.js 15 + Supabase applications. Use when implementing user authentication, protecting routes, managing user sessions, enforcing…
Read, write, and convert multiple sequence alignment files using Biopython Bio.AlignIO. Supports Clustal, PHYLIP, Stockholm, FASTA, Nexus, and other alignment formats for — from…
A relentless interview that asks every frontier question at once, round by round.
Perform differential expression analysis of miRNAs between conditions using DESeq2 or edgeR with small RNA-specific considerations.
Query ClinicalTrials.gov via API v2. Search trials by condition, drug, location, status, or phase. Retrieve trial details by NCT ID, export data, for clinical research an — from…
Preprocessing and harmonization of multi-omics data before integration. Covers normalization, batch correction, feature alignment, and missing value handling across data — from…
Align short reads using Bowtie2 with local or end-to-end modes. Supports gapped alignment. Use when aligning ChIP-seq, ATAC-seq, or when flexible alignment modes are need — from…
When the user wants to design, optimize, or audit masonry (Pinterest-style) layouts for content display.
Master Flutter development with Dart 3, advanced widgets, and multi-platform deployment. — from bg-szy/TOP-SKILLS
DevOps/SRE 工程师 Agent — 覆盖 CI/CD 流水线、容器化与 K8s、基础设施即代码、可观测性、SLO/SLI/Error Budget、容量规划、混沌工程、事故响应与复盘、成本优化等全领域工作。能动手执行，不只是出方案。
Generate and edit images with Alibaba Qwen-Image-2.0 models via inference.sh CLI. Models: Qwen-Image-2.0 (fast), Qwen-Image-2.0-Pro (professional text rendering).
Sweep a contracts folder and extract every renewal date, auto-renew clause, notice window, and price-escalation term into a renewal calendar -- then create calendar remin — from…
Expert at Playwright E2E tests, Vitest unit tests, Storybook interaction tests. Use when writing tests, debugging test failures, or improving test coverage.
Integrate multiple scRNA-seq samples/batches using Harmony, scVI, Seurat anchors, and fastMNN. Remove technical variation while preserving biological differences.
Calculate translation efficiency (TE) as the ratio of ribosome occupancy to mRNA abundance. Use when comparing translational regulation between conditions or identifying — from…
Analyzes cfDNA methylation patterns for cancer detection using cfMeDIP-seq or bisulfite sequencing with MethylDackel.
Expert guide on prompt engineering patterns, best practices, and optimization techniques. Use when user wants to improve prompts, learn prompting strategies, or debug age — from…
Handle paired-end FASTQ files (R1/R2) using Biopython. Use when working with Illumina paired reads, synchronizing pairs, interleaving/deinterleaving, or filtering paired — from…
支付工程师 Agent — 覆盖支付系统架构设计、渠道对接、交易核心开发、对账清算、风控安全、性能优化全流程。支持 Java/Go/Python 技术栈，深度使用分布式中间件。
Generate and edit images with Alibaba Qwen-Image-2.0 models via inference.sh CLI. Models: Qwen-Image-2.0 (fast), Qwen-Image-2.0-Pro (professional text rendering).
Calls significant loops from protein-directed and targeted 3C assays (HiChIP, PLAC-seq, Capture Hi-C/PCHi-C, ChIA-PET) where the contact background is peak-anchored and…
Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-fa — from…
Align protein structures using Foldseek 3Di, TM-align, US-align, DALI, or Foldmason for structural MSA.
Guide for implementing obsidian.nvim - a Neovim plugin for Obsidian vault management. Use when configuring, troubleshooting, or extending obsidian.nvim features including…
When the user wants to create, optimize, or structure legal pages (Privacy, Terms, etc.). Also use when the user mentions "privacy policy," "terms of service," "legal pages,"…
Comprehensive toolkit for creating, analyzing, and visualizing complex networks and graphs in Python.
Access BRENDA enzyme database via SOAP API. Retrieve kinetic parameters (Km, kcat), reaction equations, organism data, and substrate-specific enzyme information for bioch — from…
Generate AI videos with Google Veo, Seedance 2.0, HappyHorse, Wan, Grok and 40+ models via inference.sh CLI.
Balance, normalize, and transform Hi-C contact matrices using cooler and cooltools. Apply iterative correction (ICE), compute expected values, and generate observed/expec — from…
Upgrade React applications to latest versions, migrate from class components to hooks, and adopt concurrent features.
Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools.
Comprehensive testing workflow combining TDD, real implementations (no mocking), and E2E testing. Use when implementing features, writing tests, or setting up test infrastructure.
Build local BLAST databases and run searches using NCBI BLAST+ command-line tools. Use when running >50 queries, building custom databases with -parse_seqids and -taxid,…
Review Jupyter notebooks for side effects, dependencies, and safe execution strategy before running or editing them.
Create and manage Claude Code skills following Anthropic best practices. Use when creating new skills, modifying skill-rules.json, understanding trigger patterns, working — from…
End-to-end neoantigen discovery from somatic variants to ranked vaccine candidates. Integrates HLA typing, MHC binding prediction, pVACtools neoantigen calling, and immun — from…
Manage Git workflows including commits, branches, merges, and collaboration. Use when working with Git repositories, creating commits, managing branches, or resolving conflicts.