Production-ready reinforcement learning algorithms (PPO, SAC, DQN, TD3, DDPG, A2C) with scikit-learn-like API.
Deslop, humanize, edit, or audit AI-sounding, robotic, generic, corporate, or ChatGPT-like copy while preserving the writer's voice.
Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Li & Hart 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and…
Perform multiple sequence alignment using MAFFT, MUSCLE5, ClustalOmega, or T-Coffee. Guides tool and algorithm selection based on dataset size, sequence divergence, and downstream…
Generates the storyboard sheets for a video — one image per clip, panels in a row, each panel one action.
Comprehensive research assistant that synthesizes information from multiple sources with citations. Use when: conducting in-depth research, gathering sources, writing research…
Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio.
Marker gene-based taxonomic profiling using MetaPhlAn 4. Provides accurate species-level relative abundances using clade-specific markers.
Perform geometric calculations on protein structures using Biopython Bio.PDB. Use when measuring distances, angles, and dihedrals, superimposing structures, calculating R — from…
End-to-end small RNA-seq analysis from FASTQ to differential miRNA expression. Use when analyzing miRNA, piRNA, or other small RNA sequencing data. — from bg-szy/TOP-SKILLS
Toolkit for interacting with and testing local web applications using Playwright. Supports verifying frontend functionality, debugging UI behavior, capturing browser scre — from…
Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag).
Construct and analyze compound-target-disease networks for drug repurposing, polypharmacology discovery, and systems pharmacology.
Analyze cell-cell communication in spatial transcriptomics data using ligand-receptor analysis with Squidpy.
Generate and maintain OpenAPI 3.1 specifications from code, design-first specs, and validation patterns.
Interactive cell type annotation for IMC data. Covers napari-based annotation, marker-guided labeling, training data generation, and annotation validation.
Create a concise plan. Use when a user explicitly asks for a plan related to a coding task. — from bg-szy/TOP-SKILLS
Transform GWAS signals into actionable drug targets and repurposing opportunities. Performs locus-to-gene mapping, target druggability assessment, existing drug identification,…
Systematically evaluate scholarly work using the ScholarEval framework, providing structured assessment across research quality dimensions including problem formulation — from…
World-class data engineering skill for building scalable data pipelines, ETL/ELT systems, and data infrastructure.
Quality control, filtering, normalization, and feature selection for spatial transcriptomics data. Calculate QC metrics, filter spots/cells, normalize counts, and identif — from…
Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package.
Vitest testing patterns and strategies for unit tests, agent tests, and API tests with Supabase mocking
Create new Claude Code Skills with proper YAML frontmatter, progressive disclosure structure, and complete directory organization.
Compare cell-type composition and spatial features across conditions in IMC/MIBI cohorts with the patient as the experimental unit, covering pseudoreplication, per-patient…
Detect and track antimicrobial resistance genes using AMRFinderPlus and ResFinder with epidemiological context.
Validate Ribo-seq data quality by checking 3-nucleotide periodicity and calculating P-site offsets. Use when assessing library quality or determining read offsets for dow — from…
AI-driven patient-to-trial matching for precision medicine and oncology. Given a patient profile (disease, molecular alterations, stage, prior treatments), discovers and ranks…
Comprehensive antibody engineering and optimization for therapeutic development. Covers humanization, affinity maturation, developability assessment, and immunogenicity…
Comprehensive security engineering skill for application security, penetration testing, security architecture, and compliance auditing.
Guide for creating Claude Code skills following Anthropic's official best practices. Use when user wants to create a new skill, build a skill, write SKILL.md, or needs sk — from…
When the user wants to design, optimize, or audit masonry (Pinterest-style) layouts for content display.
Master advanced prompt engineering techniques to maximize LLM performance, reliability, and controllability in production.
Build automated billing systems for recurring payments, invoicing, subscription lifecycle, and dunning management.
End-to-end Ribo-seq analysis from FASTQ to translation efficiency and ORF detection. Use when analyzing ribosome profiling data to study translation. — from bg-szy/TOP-SKILLS
Use when needing clinical significance, pathogenicity classifications (e.g., Pathogenic, Benign, VUS), clinical evidence rationales, or finding \"hard positive\" benchmark…
Filter and select sequences by criteria (length, ID, GC content, patterns) using Biopython. Use when subsetting sequences, removing unwanted records, or selecting by spec — from…
Ultra-compressed communication mode. Cuts token usage ~75% by dropping filler, articles, and pleasantries while keeping full technical accuracy.
Infers person-to-person transmission from pathogen genomes using outbreaker2 (Campbell 2018), TransPhylo (Didelot 2017), phybreak (Klinkenberg 2017), BadTrIP (De Maio 2018),…
When the user wants to create LinkedIn post copy or optimize for LinkedIn. Also use when the user mentions "LinkedIn post," "LinkedIn article," "professional post," "post — from…
Cloud-based AI swarm deployment and event-driven workflow automation with Flow Nexus platform — from bg-szy/TOP-SKILLS
Estimates cell-type composition from bulk DNA methylation and uses it to defuse the single biggest EWAS confounder.
Generate AI music on RunComfy via the `runcomfy` CLI. Routes to ElevenLabs Music (premium vocal, $0.0083/s) or ACE Step / 1.5 (open-weights, $0.0002–0.0003/s, multilingual), plus…
NGS analysis toolkit. BAM to bigWig conversion, QC (correlation, PCA, fingerprints), heatmaps/profiles (TSS, peaks), for ChIP-seq, RNA-seq, ATAC-seq visualization.
Build slide decks and presentations for research talks. Use this for making PowerPoint slides, conference presentations, seminar talks, research presentations, thesis def — from…
Use when Codex, Hermes, OpenClaw, Claude Code, Cowork, or another AI agent needs to plan, review, implement, audit, or improve email work focused on behavioral triggers — from…
Parse and write protein structure files using Biopython Bio.PDB. Use when reading PDB, mmCIF, and MMTF files, downloading structures from RCSB PDB, or writing structures — from…
Use when completing tasks, implementing major features, or before merging to verify work meets requirements — from bg-szy/TOP-SKILLS
Create restriction maps showing enzyme cut positions on DNA sequences using Biopython Bio.Restriction.
Convert Stitch HTML designs into React Native screens using native primitives, StyleSheet rules, and mobile platform checks.
Create well-formatted git commits with conventional commit messages and emoji. Use when user asks to commit changes, save work, or after completing a task that should be committed.
Use when encountering any bug, test failure, or unexpected behavior, before proposing fixes - four-phase framework (root cause investigation, pattern analysis, hypothesis — from…
Search a codebase or UI for places that don't animate but should, and reject everything that shouldn't. Read-only; it proposes motion with exact values, it does not implement it.
Comprehensive spreadsheet creation, editing, and analysis with support for formulas, formatting, data analysis, and visualization.
Normalize indel representation, decompose MNPs, and split multiallelic variants using bcftools norm. Use when comparing variants from different callers, preparing VCF for database…
Predict peptide-MHC class I and II binding affinity using MHCflurry and NetMHCpan neural network models. Identify potential T-cell epitopes from protein sequences.
Analyzes disease patterns and health events through epidemiological lens using surveillance systems, — from bg-szy/TOP-SKILLS
Graph Neural Networks (PyG). Node/graph classification, link prediction, GCN, GAT, GraphSAGE, heterogeneous graphs, molecular property prediction, for geometric deep lear — from…
Statistical testing for differentially abundant proteins between conditions. Covers preprocessing (log2 transformation, normalization), limma and DEqMS workflows with emp — from…
Generates standardized quality control reports by aggregating metrics from FastQC, alignment, and other tools using MultiQC.