Generate and edit images on RunComfy via the `runcomfy` CLI — a smart router across the full image-model catalog: FLUX 2 (Klein 9B/4B, Pro, Dev, Flash, Turbo, Max), Googl — from…
Write, review, or improve SwiftUI code following best practices for state management, view composition, performance, modern APIs, Swift concurrency, and iOS 26+ Liquid Gl — from…
Filter reads by quality scores, length, and N content using Trimmomatic and fastp. Apply sliding window trimming, remove low-quality bases from read ends, and discard rea — from…
Performs set operations on genomic intervals - intersect (-wa/-wb/-wo/-wao/-loj/-c/-v/-u), subtract (-A), merge (-d, -c/-o), complement, cluster, multiinter, unionbedg, map, and…
Build evaluation frameworks for agent systems. Use when testing agent performance systematically, validating context engineering choices, or measuring improvements over t — from…
Generate, inpaint, and outpaint music with ACE Step on RunComfy via the `runcomfy` CLI. ACE Step is StepFun-AI's open-weights music foundation model — tag-driven composit — from…
Choose a landing page or sales funnel platform by working out the real total cost and lock-in for a specific case - comparing ClickFunnels, CartFlows, FunnelKit, systeme.io,…
Extend scRNA-seq developmental trajectories with BulkTrajBlend by generating intermediate cells from bulk RNA-seq, training beta-VAE and GNN models, and interpolating mis — from…
Use when creating new skills, documenting workflows, or standardizing processes into reusable skill definitions.
When the user wants open source strategy, OSS commercialization, or open source growth. Also use when the user mentions "open source strategy," "OSS strategy," "open source…
Diffusion-based molecular docking. Predict protein-ligand binding poses from PDB/SMILES, confidence scores, virtual screening, for structure-based drug design.
Guide for implementing HolmesGPT - an AI agent for troubleshooting cloud-native environments. Use when investigating Kubernetes issues, analyzing alerts from Prometheus/A — from…
When the user wants to create, optimize, or audit customer stories or case study pages. Also use when the user mentions "case studies," "customer stories," "success stories,"…
Design multi-stage CI/CD pipelines with approval gates, security checks, and deployment orchestration.
Create AI avatar and talking head videos via inference.sh CLI. Recommended: P-Video-Avatar (fastest, cheapest, built-in TTS). Also: OmniHuman, Fabric, PixVerse.
When the user wants to create or optimize a shipping or delivery information page. Also use when the user mentions "shipping," "delivery," "shipping policy," "delivery times,"…
Create publication-quality visualizations of immune repertoire data including circos plots, clone tracking, diversity plots, and network graphs.
When the user wants to run display, banner, or ad network campaigns. Also use when the user mentions "display ads," "banner ads," "ad network," "ad alliance," "programmatic…
When the user wants to create Pinterest Pins, optimize Pin descriptions, or grow Pinterest presence. Also use when the user mentions "Pinterest," "Pin," "Pinterest SEO," — from…
When the user wants to create, optimize, or audit pricing page content and structure. Also use when the user mentions "pricing page," "pricing table," "plans," "subscription,"…
When the user wants to create TikTok video captions, scripts, or optimize for TikTok. Also use when the user mentions "TikTok post," "TikTok caption," "TikTok video," "po — from…
Use when you have a written implementation plan to execute in a separate session with review checkpoints — from bg-szy/TOP-SKILLS
Automated LLM-driven hypothesis generation and testing on tabular datasets. Use when you want to systematically explore hypotheses about patterns in empirical data (e.g — from…
Implement comprehensive evaluation strategies for LLM applications using automated metrics, human feedback, and benchmarking.
Taxonomic classification of ASVs using reference databases like SILVA, GTDB, or UNITE. Covers naive Bayes classifiers (DADA2, IDTAXA) and exact matching approaches.
Create AI marketing videos for ads, promos, product launches, and brand content. Models: Veo, Seedance, Wan, FLUX for visuals, Kokoro for voiceover.
Build comprehensive attack trees to visualize threat paths. Use when mapping attack scenarios, identifying defense gaps, or communicating security risks to stakeholders.
Four-phase debugging framework that ensures root cause identification before fixes. Use when encountering bugs, test failures, unexpected behavior, or when previous fix attempts…
Comprehensive computational validation of drug targets for early-stage drug discovery. Evaluates targets across 10 dimensions (disambiguation, disease association, druggability,…
Analyze competitor website structures, messaging patterns, and unique features. Use when researching competition, identifying gaps, or informing content strategy.
Game design principles. GDD structure, balancing, player psychology, progression. — from bg-szy/TOP-SKILLS
Implements authentication and payment features using Clerk, Supabase Auth, or Stripe. Use when user mentions ログイン, 認証, auth, authentication, Clerk, Supabase, 決済, payment, Stripe,…
Map metabolites to biological pathways using KEGG, Reactome, and MetaboAnalyst. Perform pathway enrichment and topology analysis.
You MUST use this before any creative work - creating features, building components, adding functionality, or modifying behavior.
Gene set enrichment analysis with correct geneset format handling. Critical guidance for loading pathway databases and running enrichment in OmicVerse. — from bg-szy/TOP-SKILLS
Unified content extraction and action planning. Use when user says "learn-this <URL>", "learn this <URL>", "weave <URL>", "help me plan <URL>", "extract and plan <URL>" — from…
Create new Claude Code Skills with proper YAML frontmatter, progressive disclosure structure, and complete directory organization.
Generate AI images with FLUX, Gemini, Grok, Seedream, Reve and 50+ models via inference.sh CLI. Models: FLUX Dev LoRA, FLUX.2 Klein LoRA, Gemini 3 Pro Image, Grok Imagine — from…
UMAP dimensionality reduction. Fast nonlinear manifold learning for 2D/3D visualization, clustering preprocessing (HDBSCAN), supervised/parametric UMAP, for high-dimensio — from…
When the user wants to optimize heading structure (H1-H6), fix heading hierarchy, or improve content structure.
Query the ChEMBL database for bioactive molecules, drug targets, bioactivity data, approved drugs, and chemical structures.
Production-ready reinforcement learning algorithms (PPO, SAC, DQN, TD3, DDPG, A2C) with scikit-learn-like API.
Call accessible chromatin regions from ATAC-seq BAM files using MACS3, MACS2, Genrich, or HMMRATAC. Use when identifying open chromatin from aligned ATAC-seq, choosing between…
Build publication-quality figures in R with ggplot2 using the grammar of graphics (data + aesthetics + geometries + scales + facets + themes) with CVD-safe palettes, cairo_pdf…
Reusable plotting functions for common omics visualizations. Custom ggplot2/matplotlib implementations of volcano, MA, PCA, enrichment dotplots, boxplots, and survival cu — from…
Walk Claude through PyDESeq2-based differential expression, including ID mapping, DE testing, fold-change thresholding, and enrichment visualisation. — from bg-szy/TOP-SKILLS
Frontend development guidelines for React/TypeScript applications. Modern patterns including Suspense, lazy loading, useSuspenseQuery, file organization with features dir — from…
Creating algorithmic art using p5.js with seeded randomness and interactive parameter exploration. Use this when users request creating art using code, generative art, al — from…
Documentation quality standards and writing principles. Use when establishing formatting rules, reviewing doc quality metrics, creating writing guidelines, or enforcing consistent…
When the user wants to optimize for entity recognition, Knowledge Graph, or entity-based SEO. Also use when the user mentions "entity SEO," "entity optimization," "Knowle — from…
Investigate a question against high-trust primary sources and capture the findings as a Markdown file in the repo.
Comprehensive quality control for flow cytometry and CyTOF data. Covers flow rate stability, signal drift, margin events, dead cell exclusion, and batch QC.
Redesign or QA PDFs for clarity while preserving IDs, dates, amounts, barcodes, QR codes, seals, signatures, labels, and meaning.
Type-driven design patterns in Rust - typestate, newtype, builder pattern, and compile-time guarantees — from bg-szy/TOP-SKILLS
Track bacterial strains using MASH, sourmash, fastANI, and inStrain. Compare genomes, detect contamination, and monitor strain-level variation.
Orchestrates an end-to-end MeRIP-seq / m6A-seq analysis from raw FASTQ to differential m6A peak calls and metagene plots, chaining fastp adapter trimming, STAR splice-aware genome…
Extract text and tables from PDF files, fill forms, merge documents. Use when working with PDF files or when the user mentions PDFs, forms, or document extraction.
Workflow from differential expression results to functional enrichment analysis. Covers GO, KEGG, Reactome enrichment with clusterProfiler and visualization.
Provide actionable treatment recommendations for cancer patients based on molecular profile. Interprets tumor mutations, identifies FDA-approved therapies, finds resistance…
Resolve subclonal copy number, whole-genome doubling, and copy-number tumor evolution from bulk sequencing with Battenberg, TITAN, and MEDICC2.