Calculate immune repertoire diversity metrics, compare samples, and track clonal dynamics using VDJtools.
Preprocess ribosome profiling data including adapter trimming, size selection, rRNA removal, and alignment.
Prepare for US medical licensing exams with progress tracking, weak area analysis, question bank management, and residency match planning.
Techniques for analyzing existing codebases to reverse-engineer requirements and understand business logic.
RNA-seq specific quality control including rRNA contamination detection, strandedness verification, gene body coverage, and transcript integrity metrics.
Clean Architecture and SOLID principles guide. Use this when designing systems, reviewing architecture, or making structural decisions.
Analyze high-resolution spatial platforms like Slide-seq, Stereo-seq, and Visium HD. Use when working with subcellular resolution or high-density spatial data.
Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or…
Create scientific conference posters as native, editable .pptx files using python-pptx. Handles A0/A1 layouts, section placement, figure insertion, and academic color schemes.
Navigate the Bio.PDB SMCRA hierarchy (Structure-Model-Chain-Residue-Atom) safely, surfacing the heterogeneity it hides by default.
Picks random winners from lists, spreadsheets, or Google Sheets for giveaways, raffles, and contests. Ensures fair, unbiased selection with transparency. — from bg-szy/TOP-SKILLS
Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS,…
Generate images with Google Gemini native image models via inference.sh CLI. Models: Gemini 3 Pro Image, Gemini 2.5 Flash Image.
Aligns and QCs methylated-RNA-immunoprecipitation (MeRIP / m6A-seq) IP and input libraries using STAR or HISAT2 splice-aware mapping, samtools sort/index, IP/input matched-pair…
Detect and fix design drift — the ad-hoc colors, spacing, type sizes, shadows, and duplicate component variants that accumulate outside the design system and harden into debt.
Build a complete typographic system -- modular or fluid type scale, line-height and tracking per size, weight roles, and vertical rhythm -- exported as tokens, Tailwind config,…
Detect, date, and contextualize whole-genome duplication (WGD / paleopolyploidy) events using wgd v2 (Chen & Zwaenepoel 2024), KsRates (Sensalari 2022 substitution-rate-corrected…
Use when Codex, Hermes, OpenClaw, Claude Code, Cowork, or another AI agent needs to plan, review, implement, audit, or improve email work focused on agentic email plannin — from…
Create pull requests following Sentry conventions. Use when opening PRs, writing PR descriptions, or preparing changes for review.
Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains.
Provide actionable treatment recommendations for cancer patients based on molecular profile. Interprets tumor mutations, identifies FDA-approved therapies, finds resistance…
Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo…
Create AI avatar, talking-head, and lip-sync videos on RunComfy via the `runcomfy` CLI. Routes across ByteDance OmniHuman (audio-driven full-body avatar), Wan-AI Wan 2-7 — from…
Execute autonomous multi-step research using Google Gemini Deep Research Agent. Use for: market analysis, competitive landscaping, literature reviews, technical research — from…
Generate full songs and instrumental tracks with ElevenLabs Music on RunComfy via the `runcomfy` CLI.
Generate, inpaint, and outpaint music with ACE Step on RunComfy via the `runcomfy` CLI. ACE Step is StepFun-AI's open-weights music foundation model — tag-driven composit — from…
Apply STRIDE methodology to systematically identify threats. Use when analyzing system security, conducting threat modeling sessions, or creating security documentation.
When the user wants to run app install ads, user acquisition (UA), or promote mobile apps. Also use when the user mentions "app ads," "app install ads," "UA," "user acquisition,"…
Single-cell ATAC-seq analysis with Signac (R/Seurat) and ArchR. Process 10X Genomics scATAC data, perform QC, dimensionality reduction, clustering, peak calling, and moti — from…
When the user wants to add or optimize trust badges, "Trusted by" logos, security seals, or social proof elements.
List OKX Agentic Wallet exclusive trading competitions, register users for contests, track participation and leaderboard rankings, and claim won rewards.
Transforms workflow to use Manus-style persistent markdown files for planning, progress tracking, and knowledge storage.
Test whether cell-type proportions or composition changed between conditions in single-cell data using Milo (miloR), scCODA, sccomp, and propeller.
Draw and export phylogenetic trees using Biopython Bio.Phylo with matplotlib and modern alternatives.
Review homework notebooks for completeness, reproducibility, safe execution, and academic-integrity boundaries.
Generate AI videos on RunComfy via the `runcomfy` CLI — a smart router across the full video-model catalog: HappyHorse 1.0 (Arena #1, native in-pass audio), Wan-AI Wan 2- — from…
Drive Chromium from standard Playwright APIs with a real-device fingerprint applied inside the browser kernel, one persistent isolated profile per identity, and a per-profile…
Find Reddit threads where people are genuinely asking for what you offer, then draft short, genuinely helpful replies — disclosing your affiliation honestly and naming your…
Use when receiving code review feedback, before implementing suggestions, especially if feedback seems unclear or technically questionable - requires technical rigor and — from…
Use when user asks 'how should I...' or 'what's the best approach...' after exploring code, OR when you've tried to solve something and are stuck, OR for unfamiliar workflows, OR…
Type-driven design patterns in Rust - typestate, newtype, builder pattern, and compile-time guarantees — from bg-szy/TOP-SKILLS
Detect and remove doublets (two or more cells in one droplet) from single-cell RNA-seq using scDblFinder (R), Scrublet (Python), and DoubletFinder (R).
Upgrade React applications to latest versions, migrate from class components to hooks, and adopt concurrent features.
Phase genotypes into haplotypes using Beagle or SHAPEIT. Resolves which alleles are inherited together on each chromosome.
Comprehensive backend development skill for building scalable backend systems using NodeJS, Express, Go, Python, Postgres, GraphQL, REST APIs.
Corrects fluorophore spillover (conventional compensation) or spectral overlap (spectral unmixing) and applies variance-stabilizing transforms (logicle/biexponential, arcsinh,…
Use when Codex, Hermes, OpenClaw, Claude Code, Cowork, or another AI agent needs to plan, review, implement, audit, or improve email work focused on responsive email desi — from…
Validate, gap-fill, and curate genome-scale metabolic models using memote for quality scores and COBRApy for manual curation.
Processes eDNA metabarcoding from raw paired-end reads to species tables, navigating ASV (DADA2, UNOISE3) vs OTU (swarm v2) decision (Callahan 2017 vs Schloss multi-copy-16S…
Patterns and techniques for analyzing brownfield codebases. Use when onboarding to unfamiliar code, preparing for refactoring, conducting architecture reviews, or identifying…
Design durable workflows with Temporal for distributed systems. Covers workflow vs activity separation, saga patterns, state management, and determinism constraints.
Master systematic debugging techniques, profiling tools, and root cause analysis to efficiently track down bugs across any codebase or technology stack.
Detects somatic mutations in circulating tumor DNA using variant callers optimized for low allele fractions with UMI-based error suppression.
Analyzes meeting transcripts and recordings to uncover behavioral patterns, communication insights, and actionable feedback.
Access ZINC (230M+ purchasable compounds). Search by ZINC ID/SMILES, similarity searches, 3D-ready structures for docking, analog discovery, for virtual screening and dru — from…
Turn real customer reviews, quotes, and case-study results into polished social-proof videos built in HyperFrames -- single-testimonial spotlights, review-wall montages, and…
Federated variant lookup across 9 genomic databases — GWAS Catalog, Open Targets, PheWeb (UKB, FinnGen, BBJ), GTEx, eQTL Catalogue, and more.
Token-efficient library documentation fetcher using Context7 MCP with 86.8% token savings through intelligent shell pipeline filtering.
Filter reads by quality scores, length, and N content using Trimmomatic and fastp. Apply sliding window trimming, remove low-quality bases from read ends, and discard rea — from…
Calculate polygenic risk scores using PRSice-2, LDpred2, or PRS-CS from GWAS summary statistics. Use when predicting disease risk from genome-wide genetic variants.